How do you make topical creams from compounds in pill form?

[Quan_Li]

Hello boyosssss! I’m trying to get some medication but the one I need isn’t available anywhere to source as far as topical, I can only get pills (Sirolimus) Has anyone ever made their own compounded topicals? And if so what’s the method? Like stability/efficacy? I just didn’t want to crush it up and be retarded if someone has other wisdom

 

[lotuus]

do you want an ointment? serum? paste?

 

[Deleted Member 125690]

very hard and expensive depending on what shit you're doing

for example minoxidil
1ml %5 concentration = 50mg worth of pills
50mg of pills is 10 like pieces

and for the head you need like 3ml which means a whole minoxidil package in pill form that's supposed to be for the whole month just for one time topical application

almost impossible because of the efficacy to cost ratio

 

[Quan_Li]

do you want an ointment? serum? paste?

I would say like a cream would be ideal, just need it to be 1% concentration

 

[lotuus]

I would say like a cream would be ideal, just need it to be 1% concentration

we don’t know how much sirolimus reaches the skin or what effect it would have. Evidence for topical sirolimus comes from specially compounded/formulated products, not crushed tablets.
If you crush it however, you can mix with a carrier oil depending on your skin texture.
If your skin is oily or acne-prone: use jojoba oil
dry skin: pure apricot oil or avocado oils
sensitive skin: almond oil
You can also get these in beeswax textures for more of a cream substance.
Mark as sol.

 

[Dearpleasehelpme]

Hello boyosssss! I’m trying to get some medication but the one I need isn’t available anywhere to source as far as topical, I can only get pills (Sirolimus) Has anyone ever made their own compounded topicals? And if so what’s the method? Like stability/efficacy? I just didn’t want to crush it up and be retarded if someone has other wisdom

Eat topical creams

 

[Quan_Li]

very hard and expensive depending on what shit you're doing

for example minoxidil
1ml %5 concentration = 50mg worth of pills
50mg of pills is 10 like pieces

and for the head you need like 3ml which means a whole minoxidil package in pill form that's supposed to be for the whole month just for one time topical application

almost impossible because of the efficacy to cost ratio

Fair enough, I can spend really as much as I need, it’s for 1% Sirolimus cream. Idc ab price for now

 

[Quan_Li]

we don’t know how much sirolimus reaches the skin or what effect it would have. Evidence for topical sirolimus comes from specially compounded/formulated products, not crushed tablets.
If you crush it however, you can mix with a carrier oil depending on your skin texture.
If your skin is oily or acne-prone: use jojoba oil
dry skin: pure apricot oil or avocado oils
sensitive skin: almond oil
You can also get these in beeswax textures for more of a cream substance.
Mark as sol.

That is true that the evidence zones from topical, but aside from special formulations it should absorb at close to the same rate. I would just be concerned with concentration. How would you go about distributing it in the cream as “evenly” as possible?

 

[lotuus]

That is true that the evidence zones from topical, but aside from special formulations it should absorb at close to the same rate. I would just be concerned with concentration. How would you go about distributing it in the cream as “evenly” as possible?

wait I have a good idea
Why don’t you just get a topical you can actually get your hands on the crush half the pill into a small amount and apply??

 

[Quan_Li]

wait I have a good idea
Why don’t you just get a topical you can actually get your hands on the crush half the pill into a small amount and apply??

Def would work, I just asked here because of stability, If there was a good way to crush/dissolve it for best consistency, and then what topical is stable for this/what won’t fuck up the active

 

[lotuus]

Def would work, I just asked here because of stability, If there was a good way to crush/dissolve it for best consistency, and then what topical is stable for this/what won’t fuck up the active

I will look into it for you, lets find neutral base and acidity for a neutral solution that won’t interfere with the pill itself!

 

[Quan_Li]

I will look into it for you, lets find neutral base and acidity for a neutral solution that won’t interfere with the pill itself!

You are absolutely fucking GOATED. Once you know (and I’ll keep researching too) def the solution! Thank you my guy

 

[lotuus]

You are absolutely fucking GOATED. Once you know (and I’ll keep researching too) def the solution! Thank you my guy

Gotcha!!!!
Found three options.
liposomal cream/gel base its literally designed for topical drug delivery and probably best if your skin is sensitive, i’d say this is the best option.

specialized emulsion or anhydrous cream base
If you have oily skin, go with the emulsion, as its more of a serum based moisturizer, also a topical vehicle.
The anhydrous cream has no water, so it’s definitely for dry skin, pretty thick.
The concentration is kinda unpredictable tho for all of solutions you try.

 

[Quan_Li]

Gotcha!!!!
Found three options.
liposomal cream/gel base its literally designed for topical drug delivery and probably best if your skin is sensitive, i’d say this is the best option.

specialized emulsion or anhydrous cream base
If you have oily skin, go with the emulsion, as its more of a serum based moisturizer, also a topical vehicle.
The anhydrous cream has no water, so it’s definitely for dry skin, pretty thick.
The concentration is kinda unpredictable tho for all of solutions you try.

Thank you bro! I’ll mess with the concentration side myself. Appreciate all the help, time to lock in!

 

[lotuus]

Thank you bro! I’ll mess with the concentration side myself. Appreciate all the help, time to lock in!

Remember my help when motm rolls around