Hypothesis Is DHT the actually cause of hairloss?

[Currycelloser]

Well no, it maybe a co factor but there is no evidence that high dht directly causes hairloss.

For the last 20 years, the testosterone levels has been decreasing

as u can see from this graph, we also know that low testosterone equals low dht.

then why do we have increasing hairloss rates?

If DHT was the primary cause of hair loss then we must have decreasing hair loss rates, but the graph shows inversely.

Yes hairloss is determined by genetical sensitivity of ur hair follicles to DHT and yes nuking DHT to death does work in regrowing ur hair but nuking DHT is a terrible idea and has many side effects such as:

Erectile dysfunction, Mental problems, Gyno, etc.
Also very low DHT can be a promoting factor for prostate cancer(very high DHT could be the cause too)

Health Risks Associated with Long-Term Finasteride and Dutasteride Use: It's Time to Sound the Alarm - PMC

5α-dihydrotestosterone (5α-DHT) is the most potent natural androgen. 5α-DHT elicits a multitude of physiological actions, in a host of tissues, including prostate, seminal vesicles, hair follicles, skin, kidney, and lacrimal and meibomian glands. ...

pmc.ncbi.nlm.nih.gov

Negative Impact of Testosterone Deficiency and 5α-Reductase Inhibitors Therapy on Metabolic and Sexual Function in Men - PubMed

Androgens are steroid hormones with pleotropic and diverse biochemical and physiological functions, and androgen deficiency exerts a negative impact on human health. Testosterone (T) either directly or via its transformation into the more potent metabolite 5α-dihydrotestosterone (5α-DHT) or via...

pubmed.ncbi.nlm.nih.gov

Characteristics of Men Who Report Persistent Sexual Symptoms After Finasteride Use for Hair Loss - PubMed

We found no evidence of androgen deficiency, decreased peripheral androgen action, or persistent peripheral inhibition of SRD5A in men with persistent sexual symptoms after finasteride use. Symptomatic finasteride users revealed depressed mood and fMRI findings consistent with those observed in...

pubmed.ncbi.nlm.nih.gov

If DHT is the main cause of hairloss, then why does scalp botox sometimes help in hair regrowth

Botulinum Toxin in the Treatment of Hair and Scalp Disorders: Current Evidence and Clinical Applications - PMC

Botulinum toxin (BoNT) is well-recognized throughout dermatology for its cosmetic indications and growing therapeutic value. Recent studies have trialed BoNT in the treatment of hair and scalp disorders, many of which lack long-term effective ...

pmc.ncbi.nlm.nih.gov

A Pilot Study to Evaluate Effectiveness of Botulinum Toxin in Treatment of Androgenetic Alopecia in Males - PMC

Androgenetic alopecia is a common form of alopecia with multifactorial etiology. Finasteride and minoxidil are approved by the FDA for the treatment of androgenetic alopecia. Balding scalp is believed to have relative microvascular insufficiency. ...

pmc.ncbi.nlm.nih.gov

Botox For Hair: Do Botox Scalp Injections Promote Hair Growth?

Learn more about botox scalp injections for hair including how they impact hair loss, side effects, and the results botox for hair can offer.

wimpoleclinic.com

The real cause of hairloss:

Is inflammation:

Let me explain

The mechanism here is:
Inflammation-->DHT mobilisation-->Scalp tightness-->Oxygen/nutrients deprivation-->hair loss

Even in this equation, the DHT mobilises itself as a defence mechanism against these things. Once DHT mobilises, the androgenic activity in that area increases which leads to scalp tightness.

Now the genetic predisposition lies in the mobilisation of DHT, some people, even tho their DHT mobilises, they wont experience scalp tightness and ultimately hairloss, but some do. DHT might fit in the equation, but it is not the main driver of hairloss its inflammation.

Why does minoxidil/rosemary oil work??

Well, both of them inhibit the DHT mobilisation in the scalp and thereby preventing hairloss, but the main cause which is inflammation is not addressed so that is why u have to keep using minoxidil or rosemary oil or else you will lose your hair.


Tags
@TonyDr @Casablanco @Mandy? @Jess @over0 @Randomized Shame

 

[Currycelloser]

@Scientologist

 

[Mandy?]

I saw the video you showed me and it actually makes sense logically. Injecting Botox into the scalp is a effective method.

 

[ADAM]

It’s genetics I look test and proviron at the same time and my hair is chilling no difference at all

 

[TonyDr]

@Arsenic

 

[Mandy?]

I wonder why homeless people or surfers,people who are outside constantly never lose their hair.

 

[Currycelloser]

It’s genetics I look test and proviron at the same time and my hair is chilling no difference at all

read the part where i said even dht mobilisation wont cause hairloss to people who are not genetically prone to hairloss

 

[ADAM]

read the part where i said even dht mobilisation wont cause hairloss to people who are not genetically prone to hairloss

I will be honest I dnred it but I just wanted to flex that I have god hair genetics

 

[Currycelloser]

@Archelaus

 

[Currycelloser]

@BlendedBlade🧿

 

[BlendedBulge]

@BlendedBlade🧿

Will read later

 

[rovea]

First , “low testosterone/dht in the population should reduce hair loss “ is false because genetics and local follicle sensitivity matter more than hormones

Your mechanism “Inflammation → DHT mobilization → scalp tightness → hair loss” is speculative. There is some truth that scalp tension and poor microcirculation can affect hair health, but DHT is not just a defensive response it is the primary androgen acting

And the Botox , mino and rosemary help but they aren’t addressing root dht sensitivity

Dht side effects outweigh the benefits , but it still debatable

@Currycelloser

 

[Mandy?]

First , “low testosterone/dht in the population should reduce hair loss “ is false because genetics and local follicle sensitivity matter more than hormones

Your mechanism “Inflammation → DHT mobilization → scalp tightness → hair loss” is speculative. There is some truth that scalp tension and poor microcirculation can affect hair health, but DHT is not just a defensive response it is the primary androgen acting

And the Botox , mino and rosemary help but they aren’t addressing root dht sensitivity

Dht side effects outweigh the benefits , but it still debatable

@Currycelloser

DHT is the real male hormone,you’ll have a feminized brain without it. Watch Del Wood on TikTok and realize how thyroid issues,lack of environmental exposure could matter more. DHT is also not the biggest factor in skin aging,there’s thousands of processes,DHT is just one.

 

[rovea]

DHT is the real male hormone,you’ll have a feminized brain without it. Watch Del Wood on TikTok and realize how thyroid issues,lack of environmental exposure could matter more. DHT is also not the biggest factor in skin aging,there’s thousands of processes,DHT is just one.

I mean after growing out puberty, dht side affects in adulthood aren’t worth it

 

[Currycelloser]

First , “low testosterone/dht in the population should reduce hair loss “ is false because genetics and local follicle sensitivity matter more than hormones

was just a theory, i already wrote in the thread that genetics and follicle sensitivity matter more

Your mechanism “Inflammation → DHT mobilization → scalp tightness → hair loss” is speculative. There is some truth that scalp tension and poor microcirculation can affect hair health, but DHT is not just a defensive response it is the primary androgen acting

Oxidative stress in hair follicle development and hair growth: Signalling pathways, intervening mechanisms and potential of natural antioxidants - PMC

Hair follicle development and hair growth are regulated by multiple factors and multiple signalling pathways. The hair follicle, as an important skin appendage, is the basis for hair growth, and it has the functions of safeguarding the body, ...

pmc.ncbi.nlm.nih.gov

Inflammation in androgenetic alopecia and hair loss: linking neurosciences-endocrinology-dermatology

1. Marty E. Sawaya, MD, PhD (mesawaya{at}att.net) 1. Ocala, Florida, USA The development of androgenetic alopecia (AGA) depends on genetics and androgens, but the specific cellular and molecular events taking place in this multifaceted, complex interaction are vague and unknown. A recent

www.ishrs-htforum.org

DHT

mobilisation only occurs due to inflammation in the first place anyways

And the Botox , mino and rosemary help but they aren’t addressing root dht sensitivity

i said that in the thread, if u wanna use minox or rosemary u gotta use it forever, the root cause is inflammation btw

Dht side effects outweigh the benefits , but it still debatable

true

 

[TonyDr]

Yes hairloss is determined by genetical sensitivity of ur hair follicles to DHT and yes nuking DHT to death does work in regrowing ur hair but nuking DHT is a terrible idea and has many side effects such as:

Erectile dysfunction, Mental problems, Gyno, etc.
Also very low DHT can be a promoting factor for prostate cancer(very high DHT could be the cause too)

That's why i advocate for low dose topical Fin only so you reduce scalp DHT and not serum DHT.
The side effects you've mentionned are under 5mg of Fin, but nowadays there are promising studies about 0.25mg giving the same results without sides (if the hairloss is managed in the early stages.)

For the last 20 years, the testosterone levels has been decreasing

Test levels doesn't affect DHT production imo, it's the % of conversion. Meaning even if you're low T, you'll still produce enough DHT to triggers hair loss

Is inflammation:

Let me explain

The mechanism here is:
Inflammation-->DHT mobilisation-->Scalp tightness-->Oxygen/nutrients deprivation-->hair loss

Remember that there multiple cause of hair loss, not only AGA. That's why having a serious talk with a serious dermatologist and a trichologist is mandatory. Bad diagnostic = bad results.

Why does minoxidil/rosemary oil work??

Well, both of them inhibit the DHT mobilisation in the scalp and thereby preventing hairloss, but the main cause which is inflammation is not addressed so that is why u have to keep using minoxidil or rosemary oil or else you will lose your hair.

Not true, both are very mild DHT blockers, their main benefit is bloodflow boost. Not enough in the case of AGA and minox can really dry the skin because of alcohol, and increase inflammation/first layers skin issues

If you really want to reduce inflammation, tea tree oil, diclofenac and bethametasone/hydrocortisone will give better results for reducing scalp inflammation

 

[Mandy?]

I mean after growing out puberty, dht side affects in adulthood aren’t worth it

Why would your body have something in it that is meant to be that is also harmful?

 

[Currycelloser]

Test levels doesn't affect DHT production imo, it's the % of conversion. Meaning even if you're low T, you'll still produce enough DHT to triggers hair loss

DHT levels are also lowering every decade bro

Remember that there multiple cause of hair loss, not only AGA. That's why having a serious talk with a serious dermatologist and a trichologist is mandatory. Bad diagnostic = bad results.

agreed but DHT is just one of them, just because nuking DHT works, its not the main cause of hair loss

 

[Currycelloser]

Not true, both are very mild DHT blockers, their main benefit is bloodflow boost. Not enough in the case of AGA and minox can really dry the skin because of alcohol, and increase inflammation/first layers skin issues

If you really want to reduce inflammation, tea tree oil, diclofenac and bethametasone/hydrocortisone will give better results for reducing scalp inflammation

agreed

 

[rovea]

Why would your body have something in it that is meant to be that is also harmful?

it’s a good hormone for masculinity not if you want to be attractive and a “mogger”

 

[TonyDr]

Why would your body have something in it that is meant to be that is also harmful?

Genetics mutation. A foid got breeded with a n***a with that mutation and here we are. Like cancers like furr-less cats

 

[Mandy?]

it’s a good hormone for masculinity not if you want to be attractive and a “mogger”

This makes so sense,DHT is Neuroprotective and I value libido a lot if I have low libido I have no life.

 

[Currycelloser]

Genetics mutation. A foid got breeded with a n***a with that mutation and here we are. Like cancers like furr-less cats

inflammation is the main and only driver of DHT mobilisation

 

[Mandy?]

I want @NewFuckingDay opinion on this honestly

 

[TonyDr]

agreed but DHT is just one of them, just because nuking DHT works, its not the main cause of hair loss

Men can suffer from multiple form of hair loss. I have telogen effluvium combined with scalp psoriasis, for example

 

[Mandy?]

inflammation is the main and only driver of DHT mobilisation

It also dosent make sense how dihydrotestosterone is responsible for proliferating and thickening body and facial hair but at the same time nuking scalp hair.

 

[Currycelloser]

telogen effluvium

Telogen Effluvium - StatPearls - NCBI Bookshelf

caused mainly due to stress btw

 

[Currycelloser]

scalp psoriasis,

its an autoimmune disorder bro, not due to DHT, so yea inflammation

 

[TonyDr]

Telogen Effluvium - StatPearls - NCBI Bookshelf

caused mainly due to stress btw

Yeah i know why i've lost some hair, due to a stressful trauma last year. Psoriasis is genetic tho

 

[ThraxxGlo]

I wonder why homeless people or surfers,people who are outside constantly never lose their hair.

no stress
they are just sitting

 

[TonyDr]

its an autoimmune disorder bro, not due to DHT, so yea inflammation

Yeah that's why i don't need Fin, but other men probably need Fin

 

[Currycelloser]

Psoriasis is genetic tho

no autoimmune disorders are genetic bro

 

[Mandy?]

 

[Mandy?]

 

[Currycelloser]

but other men probably need Fin

they need to stop being a pussy, and eat more meat and saturated fat tbh, detoxing first is very important+ hair oiling with coconut or castor, like u said tree tea oil, also egg yolks washes, luke warm to cold hair wash is what they need

 

[Mandy?]

 

[Casablanco]

Well no, it maybe a co factor but there is no evidence that high dht directly causes hairloss.

For the last 20 years, the testosterone levels has been decreasing
View attachment 176962
as u can see from this graph, we also know that low testosterone equals low dht.

then why do we have increasing hairloss rates?

If DHT was the primary cause of hair loss then we must have decreasing hair loss rates, but the graph shows inversely.

Yes hairloss is determined by genetical sensitivity of ur hair follicles to DHT and yes nuking DHT to death does work in regrowing ur hair but nuking DHT is a terrible idea and has many side effects such as:

Erectile dysfunction, Mental problems, Gyno, etc.
Also very low DHT can be a promoting factor for prostate cancer(very high DHT could be the cause too)

Health Risks Associated with Long-Term Finasteride and Dutasteride Use: It's Time to Sound the Alarm - PMC

5α-dihydrotestosterone (5α-DHT) is the most potent natural androgen. 5α-DHT elicits a multitude of physiological actions, in a host of tissues, including prostate, seminal vesicles, hair follicles, skin, kidney, and lacrimal and meibomian glands. ...

pmc.ncbi.nlm.nih.gov

Negative Impact of Testosterone Deficiency and 5α-Reductase Inhibitors Therapy on Metabolic and Sexual Function in Men - PubMed

Androgens are steroid hormones with pleotropic and diverse biochemical and physiological functions, and androgen deficiency exerts a negative impact on human health. Testosterone (T) either directly or via its transformation into the more potent metabolite 5α-dihydrotestosterone (5α-DHT) or via...

pubmed.ncbi.nlm.nih.gov

Characteristics of Men Who Report Persistent Sexual Symptoms After Finasteride Use for Hair Loss - PubMed

We found no evidence of androgen deficiency, decreased peripheral androgen action, or persistent peripheral inhibition of SRD5A in men with persistent sexual symptoms after finasteride use. Symptomatic finasteride users revealed depressed mood and fMRI findings consistent with those observed in...

pubmed.ncbi.nlm.nih.gov

If DHT is the main cause of hairloss, then why does scalp botox sometimes help in hair regrowth

Botulinum Toxin in the Treatment of Hair and Scalp Disorders: Current Evidence and Clinical Applications - PMC

Botulinum toxin (BoNT) is well-recognized throughout dermatology for its cosmetic indications and growing therapeutic value. Recent studies have trialed BoNT in the treatment of hair and scalp disorders, many of which lack long-term effective ...

pmc.ncbi.nlm.nih.gov

A Pilot Study to Evaluate Effectiveness of Botulinum Toxin in Treatment of Androgenetic Alopecia in Males - PMC

Androgenetic alopecia is a common form of alopecia with multifactorial etiology. Finasteride and minoxidil are approved by the FDA for the treatment of androgenetic alopecia. Balding scalp is believed to have relative microvascular insufficiency. ...

pmc.ncbi.nlm.nih.gov

Botox For Hair: Do Botox Scalp Injections Promote Hair Growth?

Learn more about botox scalp injections for hair including how they impact hair loss, side effects, and the results botox for hair can offer.

wimpoleclinic.com

The real cause of hairloss:

Is inflammation:

Let me explain

The mechanism here is:
Inflammation-->DHT mobilisation-->Scalp tightness-->Oxygen/nutrients deprivation-->hair loss

Even in this equation, the DHT mobilises itself as a defence mechanism against these things. Once DHT mobilises, the androgenic activity in that area increases which leads to scalp tightness.

Now the genetic predisposition lies in the mobilisation of DHT, some people, even tho their DHT mobilises, they wont experience scalp tightness and ultimately hairloss, but some do. DHT might fit in the equation, but it is not the main driver of hairloss its inflammation.

Why does minoxidil/rosemary oil work??

Well, both of them inhibit the DHT mobilisation in the scalp and thereby preventing hairloss, but the main cause which is inflammation is not addressed so that is why u have to keep using minoxidil or rosemary oil or else you will lose your hair.


Tags
@TonyDr @Casablanco @Mandy? @Jess @over0 @Randomized Shame

high effort mirin, bookmarked im reading later

 

[TonyDr]

no autoimmune disorders are genetic bro

My grand-father had it, my brother also have it. Not as aggressive as him but still

 

[MingyuePalaceRuinedMyLife]

they need to stop being a pussy, and eat more meat and saturated fat tbh, detoxing first is very important+ hair oiling with coconut or castor, like u said tree tea oil, also egg yolks washes, luke warm to cold hair wash is what they need

this is so funny im laughing too hard to be able to jfl react this

 

[Currycelloser]

My grand-father had it, my brother also have it. Not as aggressive as him but still

autoimmune is excess inflammation in ur body, yes it could be genetic in terms of how sensitive u are to inflammations but it is curable

 

[Currycelloser]

I want @NewFuckingDay opinion on this honestly

@NewFuckingDay and @BlendedBlade🧿 pin roids, so i would recommend them to be on fin and dut since DHT mobilisation would be through the roof due to high oxidative stress

 

[Mandy?]

@NewFuckingDay and @BlendedBlade🧿 pin roids, so i would recommend them to be on fin and dut since DHT mobilisation would be through the roof due to high oxidative stress

I pin roids too

 

[Deleted Member 81037]

why are you posting this like it's your own conclusion? every other idiot who thinks theorizing is about low effort googling and picking the best feel-good "explanation" of a problem is doing this

 

[Currycelloser]

why are you posting this like it's your own conclusion? every other idiot who thinks theorizing is about low effort googling and picking the best feel-good "explanation" of a problem is doing this

its just my opinion after reading some studies

 

[Deleted Member 81037]

"inflammation" means nothing in this context. it's just a buzzword that sounds meaningful to uneducated fools who cant even grasp the concept of scientific rigor

 

[Deleted Member 49073]

It's generally caused by androgenetic alopecia. Some men just have an extreme response to sex hormones (especially DHT).
AA also leads to the calcification of the perifollicular tissue in hair, leading to inhibitation of oxygen and nutrients.

Inflammation-->DHT mobilisation-->Scalp tightness-->Oxygen/nutrients deprivation-->hair loss

This is also true. Basically any function that inhibits oxygen/nutrients to reach the hair follicles will lead to hair loss.

 

[Currycelloser]

It's generally caused by androgenetic alopecia. Some men just have an extreme response to sex hormones (especially DHT).
AA also leads to the calcification of the perifollicular tissue in hair, leading to inhibitation of oxygen and nutrients.

inhibition of oxygen and nutrition is caused by mobilisation of DHT which is a response to inflammation, so technically treating ur inflammation is the best cure

 

[Deleted Member 49073]

inhibition of oxygen and nutrition is caused by mobilisation of DHT which is a response to inflammation, so technically treating ur inflammation is the best cure

So your theorising that hair loss can be solved by adopted an non-inflammatory diet? I could see why.

More antioxidants -> Neutralisation of free radicals -> Less oxidative stress -> Less inflammation -> ... -> Less hair loss

 

[TonyDr]

autoimmune is excess inflammation in ur body, yes it could be genetic in terms of how sensitive u are to inflammations but it is curable

Yeah i've optmized my diet but can't really beat it from stress tho

 

[Currycelloser]

Yeah i've optmized my diet but can't really beat it from stress tho

yea agreed, well i mean try ur best man