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Like I know you're supposed to get acclimated to it and do it like 3x a week not every night but I just started 0.025% and my skin feels fine. I definitely feel the effects though already, my skin is already a bit clearer (Idk if thats just a placebo but my like spots arent as irritated). Not sure If Im just build different and can start taking it daily. I started yesterday so I'll probably just stick to 3x a week.