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GH directly and through IGF-I stimulates osteoblast proliferation and activity, promoting bone formation. It also stimulates osteoclast differentiation and activity, promoting bone resorption. The result is an increase in the overall rate of bone remodeling, with a net effect of bone...
It seems like they’re saying it only boosted the gh levels and not any other igf1 or serum. But thats either false or its because it was done on rats
“MK-677 oral administration increased peak GH concentrations by 1.8-fold, but did not increase body growth or serum IGF-I levels. At 6 weeks, the...
“Oral administration of MK-677 at 4 mg/kg increased peak GH concentrations by 1.8-fold, compared to baseline. However, oral administration of MK-677 for 6 weeks did not increase body growth or serum levels of IGF-I. At 6 weeks after treatment, the GH response to MK-677 was abolished. Pituitary...
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