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Everyone is familiar with peptides that tan/darken your skin like melanotan-2. But there is a weird world of skin lightening peptides that I see nobody talk about. Which made me wonder why. I think the reasoning behind it is that peptides that increase melanin production work faster and more dramatically since it directly triggers your melanocytes and stacks more pigment onto pre existing pigment. But when it comes to skin lightening, the peptides work to brake around your bodies biological defense mechanism (melanin) and reduce enzyme activity. Not entirely. Which means the process is slower. People also often use lightening peptides but in topical form (which give weaker effects), rather than injecting. Due to the fact that lightening peptides are so unpopular, most of the ones I’m going to list lack human studies on them.
Having pale skin will add contrast to your features. Self hating ethnics and vampires will probably be clicking on this. I’ve decided to research into lightening peptides for the hell of it, this information might come across as “water” to people very familiar with skin bleaching and peptides, but hopefully it can still inform some people
Decapeptide-12
This peptide works to directly interfere with tyrosinase to reduce melanin synthesis. according to multiple sources https://www.tandfonline.com/doi/full/10.3109/14764172.2012.672745 it is seen as safer and arguably superior to hydroquinone. https://www.nbinno.com/article/pharmaceutical-intermediates/decapeptide-12-vs-hydroquinone-a-comparative-look-at-skin-brightening-agents
https://pmc.ncbi.nlm.nih.gov/articles/PMC11355700/
https://www.tandfonline.com/doi/full/10.3109/14764172.2012.672745#
Nonapeptide-1
This one is a melanostatin that mimics the hormone 𝛼-MSH (competitive inhibition) which in turn will weaken pigment production. It prevents melanin before it’s produced, unlike direct tyrosinase inhibitors.
Tetrapeptide-30
Like most others, this one blocks tyrosinase. It reduces POMC in keratinocytes. It helps dark spots and acne marks.
Oligopeptide-34
This compound inhibits MITF. Oligopeptide-10 is also another compound that lowers melanin signal, but it’s weaker.
Glutathione
This one is the most well known. Glutathione is a pretty well known tripeptide that anti-oxidizes the body. Through inhibiting tyrosinase and reacting with dopaquinone, it creates cysteinyl-dopa instead. Shifting eumelanin production to pheomelanin. Though it comes in many forms, I’d say sublingual and IV glutathione are the only methods that could possibly influence a pigment change. It is known to be more painful to inject tho because of its highly acidic nature and other factors. It carries way more benefits than affecting melanogenesis. It’s frequently sold in oral forms since injecting it yourself instead of going to a clinic isn’t recommended. But regardless, I’m still gonna list sources for doing IV gluta yourself. Be aware that injecting things intravenously yourself comes with a variety of extreme risks I’m sure some of you know about. Like air embolism, overdosing, infections and more. The average person is generally too retarded to do this without getting hurt.
Dosage: 600-1200mg
Pros of lightening peptides:
Nonapeptide-1 products:
https://beautyologie.com/products/h...eTHU9sOZz-kU0yxgm5UoLyLXNfJC0nYNRqpTAOZYavxx0
https://www.ulprospector.com/en/asia/PersonalCare/Detail/120654/5804272/WKPep-Whitenin
https://www.g-biotec.com/products/gebiotide-nonapeptide-1.html
https://www.g-biotec.com/products/gebiotide-pearlwhitein.html
Decapeptide products:
https://alabskincare.com/products/deca-peptide-12-brightening-serum?variant=49856666665264
Glutathione:
https://www.alanmeds.com/medication...TnP74tgI726aVB1QkZHuzZZl2Q9W-ap_xGDDhNQoKfVAm
https://www.amazon.com/Glutathione-Reduced-glutathione-Material-Powder/dp/B0DY1SY35H
https://www.vitastir.com/product/glutathione-injection/?gQT=1
Tetrapeptide-30 products:
https://www.qualitide.com/products/tetrapeptide-30?utm_
https://lotioncrafter.com/products/tetrapeptide-30-solution#
TLDR: lightening peptides DO exist. But they have very limited research and studies on them. Studies show that certain ones are proven to work better than regular lightening agents, but there are unfortunately a lack of products containing these peptides in general (I listed a few I could find). But it’s always possible they might come out with some in the future
Having pale skin will add contrast to your features. Self hating ethnics and vampires will probably be clicking on this. I’ve decided to research into lightening peptides for the hell of it, this information might come across as “water” to people very familiar with skin bleaching and peptides, but hopefully it can still inform some people
Decapeptide-12
This peptide works to directly interfere with tyrosinase to reduce melanin synthesis. according to multiple sources https://www.tandfonline.com/doi/full/10.3109/14764172.2012.672745 it is seen as safer and arguably superior to hydroquinone. https://www.nbinno.com/article/pharmaceutical-intermediates/decapeptide-12-vs-hydroquinone-a-comparative-look-at-skin-brightening-agents
Due to limited research, there isn’t really an established half life (along with the majority of these peptides I’m listing). It’s been used on patients with vitiligo and hyperpigmentation. It’s a topical cosmetic peptide which makes sense since it targets tyrosinase directly which is in the basal layer of the epidermis.Research indicates that Decapeptide-12 is not only effective but also significantly more potent than hydroquinone
https://pmc.ncbi.nlm.nih.gov/articles/PMC11355700/
https://www.sciencedirect.com/science/article/abs/pii/S0378517321006736DP demonstrated high antioxidant activity, showing comparable or superior performance to Vitamin C
https://www.tandfonline.com/doi/full/10.3109/14764172.2012.672745#
Nonapeptide-1
This one is a melanostatin that mimics the hormone 𝛼-MSH (competitive inhibition) which in turn will weaken pigment production. It prevents melanin before it’s produced, unlike direct tyrosinase inhibitors.
Tetrapeptide-30
Like most others, this one blocks tyrosinase. It reduces POMC in keratinocytes. It helps dark spots and acne marks.
Oligopeptide-34
This compound inhibits MITF. Oligopeptide-10 is also another compound that lowers melanin signal, but it’s weaker.
https://dermalinstitute.com/article/oligopeptide-34/Studies comparing Oligopeptide-34 to Vitamin C and Arbutin showed Oligopeptide-34 to be superior; Vitamin C and Arbutin reduced pigmentation by 27 percent and 40 percent, respectively, while Oligopeptide-34 reduced pigmentation by 47 percent.
Glutathione
This one is the most well known. Glutathione is a pretty well known tripeptide that anti-oxidizes the body. Through inhibiting tyrosinase and reacting with dopaquinone, it creates cysteinyl-dopa instead. Shifting eumelanin production to pheomelanin. Though it comes in many forms, I’d say sublingual and IV glutathione are the only methods that could possibly influence a pigment change. It is known to be more painful to inject tho because of its highly acidic nature and other factors. It carries way more benefits than affecting melanogenesis. It’s frequently sold in oral forms since injecting it yourself instead of going to a clinic isn’t recommended. But regardless, I’m still gonna list sources for doing IV gluta yourself. Be aware that injecting things intravenously yourself comes with a variety of extreme risks I’m sure some of you know about. Like air embolism, overdosing, infections and more. The average person is generally too retarded to do this without getting hurt.
Dosage: 600-1200mg
Pros of lightening peptides:
- safe long term, no need for cycling
- Ideal for periods in between cycling depigmenting agents (like hq)
- Gentle on skin
- not as strong as certain other agents
- Less dramatic/slower results
- Fewer long term studies on most of them
Nonapeptide-1 products:
https://beautyologie.com/products/h...eTHU9sOZz-kU0yxgm5UoLyLXNfJC0nYNRqpTAOZYavxx0
https://www.ulprospector.com/en/asia/PersonalCare/Detail/120654/5804272/WKPep-Whitenin
https://www.g-biotec.com/products/gebiotide-nonapeptide-1.html
https://www.g-biotec.com/products/gebiotide-pearlwhitein.html
Decapeptide products:
https://alabskincare.com/products/deca-peptide-12-brightening-serum?variant=49856666665264
Glutathione:
https://www.alanmeds.com/medication...TnP74tgI726aVB1QkZHuzZZl2Q9W-ap_xGDDhNQoKfVAm
https://www.amazon.com/Glutathione-Reduced-glutathione-Material-Powder/dp/B0DY1SY35H
https://www.vitastir.com/product/glutathione-injection/?gQT=1
Tetrapeptide-30 products:
https://www.qualitide.com/products/tetrapeptide-30?utm_
https://lotioncrafter.com/products/tetrapeptide-30-solution#
TLDR: lightening peptides DO exist. But they have very limited research and studies on them. Studies show that certain ones are proven to work better than regular lightening agents, but there are unfortunately a lack of products containing these peptides in general (I listed a few I could find). But it’s always possible they might come out with some in the future
definitley gonna look into glutathione
