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Info Altering genes

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limo8

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  1. gene editing is real now, not sci-fi
    we can literally edit human dna to treat disease. it’s already approved, already being used. not in the far future, but now.
  2. crispr-cas9 is the tool behind it
    found in bacteria, crispr acts like precision scissors for dna. it lets scientists go into the genome and make changes at specific spots.
    source: doudna & charpentier, science 2012
  3. first real therapy: casgevy
    approved in the us and uk in 2023. used to treat sickle cell disease and beta thalassemia. both are genetic blood disorders with no real cure until now.
    source: fda approval + nejm trial data
  4. does it actually work
    yes, and results are crazy
    29 out of 30 people with sickle cell had no pain crises for over a year
    39 out of 42 people with thalassemia stopped needing transfusions
    source: frangoul et al., nejm 2021
  5. how the treatment works

  • blood stem cells are taken from the patient
  • crispr turns on a backup gene called fetal hemoglobin
  • chemo clears out the old bone marrow
  • edited cells go back in
    result is often a long-term fix

  1. where looks come into play
    this tech works on the root level. genes. that means it could potentially affect physical traits in the future
    stuff like:

  • skin aging
  • hair loss
  • jaw growth
  • fat storage
  • even height (in theory)
    nothing like this is legal yet for looks. but the base tools exist

  1. somatic vs germline
    somatic = body cells only. doesn't pass to kids. this is what we use now
    germline = edits embryos, sperm, or eggs. permanent. passes to next generations
    germline is banned in over 70 countries. still way too risky
  2. for now it's medical only
    current trials are on blindness, cancer, chronic pain, genetic disorders, etc
    nothing cosmetic. but like always, tech moves from survival to enhancement eventually. especially if it gets cheaper and safer
    site to check trials: clinicaltrials.gov
  3. what went wrong in china
    in 2018, a researcher edited embryos to be hiv-resistant. resulted in 2 births
    the science was shaky, no proper consent, long-term risks unknown
    global backlash followed. guy got jailed
    source: nature coverage 2022
  4. real talk for looksmaxxin
    we’re not editing for aesthetics yet, but this is the path.
    not surgery, not skincare, not hormones. actual blueprint-level change
    nothing is on the table right now for height, jaw, skin, etc
    but if you’re thinking long-term, this is where the game shifts
  5. for now

  • stay realistic. no legit “beauty edits” exist yet
  • follow the tech. it's evolving fast
  • if you want to get ahead, learn where this is going
  • when it does open up, early understanding will matter

resources:
crisprtx.com
scge.org
broadinstitute.org
 
  1. gene editing is real now, not sci-fi
    we can literally edit human dna to treat disease. it’s already approved, already being used. not in the far future, but now.
  2. crispr-cas9 is the tool behind it
    found in bacteria, crispr acts like precision scissors for dna. it lets scientists go into the genome and make changes at specific spots.
    source: doudna & charpentier, science 2012
  3. first real therapy: casgevy
    approved in the us and uk in 2023. used to treat sickle cell disease and beta thalassemia. both are genetic blood disorders with no real cure until now.
    source: fda approval + nejm trial data
  4. does it actually work
    yes, and results are crazy
    29 out of 30 people with sickle cell had no pain crises for over a year
    39 out of 42 people with thalassemia stopped needing transfusions
    source: frangoul et al., nejm 2021
  5. how the treatment works

  • blood stem cells are taken from the patient
  • crispr turns on a backup gene called fetal hemoglobin
  • chemo clears out the old bone marrow
  • edited cells go back in
    result is often a long-term fix

  1. where looks come into play
    this tech works on the root level. genes. that means it could potentially affect physical traits in the future
    stuff like:

  • skin aging
  • hair loss
  • jaw growth
  • fat storage
  • even height (in theory)
    nothing like this is legal yet for looks. but the base tools exist

  1. somatic vs germline
    somatic = body cells only. doesn't pass to kids. this is what we use now
    germline = edits embryos, sperm, or eggs. permanent. passes to next generations
    germline is banned in over 70 countries. still way too risky
  2. for now it's medical only
    current trials are on blindness, cancer, chronic pain, genetic disorders, etc
    nothing cosmetic. but like always, tech moves from survival to enhancement eventually. especially if it gets cheaper and safer
    site to check trials: clinicaltrials.gov
  3. what went wrong in china
    in 2018, a researcher edited embryos to be hiv-resistant. resulted in 2 births
    the science was shaky, no proper consent, long-term risks unknown
    global backlash followed. guy got jailed
    source: nature coverage 2022
  4. real talk for looksmaxxin
    we’re not editing for aesthetics yet, but this is the path.
    not surgery, not skincare, not hormones. actual blueprint-level change
    nothing is on the table right now for height, jaw, skin, etc
    but if you’re thinking long-term, this is where the game shifts
  5. for now

  • stay realistic. no legit “beauty edits” exist yet
  • follow the tech. it's evolving fast
  • if you want to get ahead, learn where this is going
  • when it does open up, early understanding will matter

resources:
crisprtx.com
scge.org
broadinstitute.org
Thanks really needed this
 
  1. gene editing is real now, not sci-fi
    we can literally edit human dna to treat disease. it’s already approved, already being used. not in the far future, but now.
  2. crispr-cas9 is the tool behind it
    found in bacteria, crispr acts like precision scissors for dna. it lets scientists go into the genome and make changes at specific spots.
    source: doudna & charpentier, science 2012
  3. first real therapy: casgevy
    approved in the us and uk in 2023. used to treat sickle cell disease and beta thalassemia. both are genetic blood disorders with no real cure until now.
    source: fda approval + nejm trial data
  4. does it actually work
    yes, and results are crazy
    29 out of 30 people with sickle cell had no pain crises for over a year
    39 out of 42 people with thalassemia stopped needing transfusions
    source: frangoul et al., nejm 2021
  5. how the treatment works

  • blood stem cells are taken from the patient
  • crispr turns on a backup gene called fetal hemoglobin
  • chemo clears out the old bone marrow
  • edited cells go back in
    result is often a long-term fix

  1. where looks come into play
    this tech works on the root level. genes. that means it could potentially affect physical traits in the future
    stuff like:

  • skin aging
  • hair loss
  • jaw growth
  • fat storage
  • even height (in theory)
    nothing like this is legal yet for looks. but the base tools exist

  1. somatic vs germline
    somatic = body cells only. doesn't pass to kids. this is what we use now
    germline = edits embryos, sperm, or eggs. permanent. passes to next generations
    germline is banned in over 70 countries. still way too risky
  2. for now it's medical only
    current trials are on blindness, cancer, chronic pain, genetic disorders, etc
    nothing cosmetic. but like always, tech moves from survival to enhancement eventually. especially if it gets cheaper and safer
    site to check trials: clinicaltrials.gov
  3. what went wrong in china
    in 2018, a researcher edited embryos to be hiv-resistant. resulted in 2 births
    the science was shaky, no proper consent, long-term risks unknown
    global backlash followed. guy got jailed
    source: nature coverage 2022
  4. real talk for looksmaxxin
    we’re not editing for aesthetics yet, but this is the path.
    not surgery, not skincare, not hormones. actual blueprint-level change
    nothing is on the table right now for height, jaw, skin, etc
    but if you’re thinking long-term, this is where the game shifts
  5. for now

  • stay realistic. no legit “beauty edits” exist yet
  • follow the tech. it's evolving fast
  • if you want to get ahead, learn where this is going
  • when it does open up, early understanding will matter

resources:
crisprtx.com
scge.org
broadinstitute.org
It’s gonna more than a hundred years before they allow it for aesthetics they don’t even allow hgh jfl. High iq thread
 
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