Deer antler velvet extract the new meta?

[HugoKys]

So I stumbled upon a new idea, deer antler valvet extract. Basically it's a dietary supplement which promotes growth of the tissue which covers bones. There haven't been much researches done on humans, however, used on rats and mice with estrogen-deficiency this supplement increased bone volume fraction.
Two thing that cuts this idea, is the fact that there hasn't been done much testing on humans, and the bones on our face grow different than deer antlers.
Could this be the new way for promoting bone growth, what's y'alls thoughts?

 

[DoctorDurden]

no.

 

[HugoKys]

no.

Why do you think so?

 

[Recession]

So I stumbled upon a new idea, deer antler valvet extract. Basically it's a dietary supplement which promotes growth of the tissue which covers bones. There haven't been much researches done on humans, however, used on rats and mice with estrogen-deficiency this supplement increased bone volume fraction.
Two thing that cuts this idea, is the fact that there hasn't been done much testing on humans, and the bones on our face grow different than deer antlers.
Could this be the new way for promoting bone growth, what's y'alls thoughts?

nah the igf u get from it is so negligable its just a waste of money

 

[Duracel]

So I stumbled upon a new idea, deer antler valvet extract. Basically it's a dietary supplement which promotes growth of the tissue which covers bones. There haven't been much researches done on humans, however, used on rats and mice with estrogen-deficiency this supplement increased bone volume fraction.
Two thing that cuts this idea, is the fact that there hasn't been done much testing on humans, and the bones on our face grow different than deer antlers.
Could this be the new way for promoting bone growth, what's y'alls thoughts?

Will never work on humans

 

[MURIOXDQ]

Just checked this suplement. 27.5 ng (0.0275 mcg) from one dosage? Don't really know if It's much or nah. Anyone know?

 

[DoctorDurden]

Why do you think so?

deer antlers are this unique mammalian regenerative kinda organ, driven by a androgen dependent mesenchymal proliferation + localized expression of IGF1 during the velvet phase or something, or whatever its called jfl. But extrapolating it to human osteogenesis simply makes no sense cuz of,

i) species specific growth pathways, the osteogenic signaling cascades in deer antlerogenesis are mediated by periosteal stem cells with a super fucking high rate of chondrogenic and osteoblastic differentiation (a rate that is orders of magnitude higher than in human skeletal tissue). Hoomans dont possess the same kinda blastema -like regenerative niche or the necessary angiogenic microenvironment to replicate this effect. So that already basically means this shit doesn't work.

and,

ii) pharmacokinetic irrelevance, even if the extract contains measurable levels of IGF1 (it actually contains just trace amounts, and afaik, after all the processing it'll contain only 1-2 nanograms per capsule, which is very low) the oral bioavailability of peptide growth factors is fucking zero due to rapid proteolytic degradation in the gastrointestinal tract (after consuming)

 

[Shiksa]

no give solution