Info GHK-CU reverses aging. Heres Why:

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GHK-CU {glycyl-L-histidyl-L-lysine} may decrease aging or even reverse it by multiple factors including of:

-GHK-CU {glycyl-L-histidyl-L-lysine} Activates ECM Remodeling.
a. COL1A1 / COL3A1 {Collagen I and III synthesis}
b .ELN {elastin}
c. GAG's {glycosaminoglycans}
d. MMP inhibitors
Why This Works?
Part 1- GHK-CU {glycyl-L-histidyl-L-lysine} binds with Cu2+ with femtomolar-nanomolar affinity and basically that contributes to forming the GHK-CU metallopeptide complex, then the complex acts as a bioactive ligand that interacts with several things such as:
-cell surface receptors
-integrin-associated networks
-metalloprotein regulatory networks
Thus making changes in fibroblasts and keratinocytes.
Part 2- This induces a repairing/regenerative fibroblast phenotype (mainly from inhanced FGF-2 signaling)
Part 3- GHK-CU {glycyl-L-histidyl-L-lysine} will then incrase transcription levelization of ECM Structural Proteins
Including of,
-COL1A1 {Collagen Type I Alpha-1}
-COL3A1 {Collagen Type III Alpha-1}
-ELN {Elastin}
-HAS2 {hyaluronan synthase}
-decorin, biglycan, and other proteoglycans
Part 4- This Factor Specifically (not dis-cluding any recent factor) Helps Restore Architecture, Overall Tensile Strength, And Hydration of the ECM.
a. Aging Skin Elevates MMP's {matrix metalloproteinases} That Break Down Collagen
b. GHK-CU {glycyl-L-histidyl-L-lysine} Down-Regulates
[ -MMP-1
[ -MMP-2
[ -MMP-9
c. GHK-CU {glycyl-L-histidyl-L-lysine} Upregulates TIMP's {tissue inhibitors of metalloproteinases} Inducing a Shift In Balance From Catabolism to Anabolism
Part 5- GHK-CU {glycyl-L-histidyl-L-lysine} Suppresses
-COX-2 {Pro-Aging Inflammatory Cascade}
-IL-6 {Pro-Aging Inflammatory Cascade}
a. Lower Inflammation
b. Reduced ECM Breakdown
-Improved Fibroblast Function
Part 6- GHK-CU {glycyl-L-histidyl-L-lysine} Reduces
-ROS {reactive oxygen species}
-Protein Carbonylation
-Lipid Peroxidation
-AGE's {advanced glycation end‑products}
This Protects ECM Proteins From Oxidative Fragmentation And Crosslinking
Part 7- GHK-CU {glycyl-L-histidyl-L-lysine}
- Up-Regulates Youth-Associated Repair Genes
-Down-Regulates SASP {senescence‑associated secretory phenotype} Genes
Part 8- GHK-CU {glycyl-L-histidyl-L-lysine} Increases
-Keratinocyte Migration
-Angiogenesis
-Granulation Tissue Formation
(This Accelerates ECM Turnover Replacing Damaged Matrix with Synthesized Collagen
Part 8- GHK-CU {glycyl-L-histidyl-L-lysine} CNS Rejuvination Signals
-Pubmed 35083444 This Study Mentions
a. Improved Cognition
b. Reduced NeuroInflammation
c. Epigenetic Pathway Modulation
Part 9- GHK-CU {glycyl-L-histidyl-L-lysine} Also Clinically Improves Skin Quality.
Study: Pubmed 35083444
https://pubmed.ncbi.nlm.nih.gov/35083444/

 

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