Discussion Ghrelin (and hence it’s mimetic) likely slows growth plate senescence via direct sox9 mediation

[90averagness82dimorphism]

Ghrelin upregulate the effect of sox9 and col2 and Acan.
https://pubmed.ncbi.nlm.nih.gov/31421834/
The upregulation of these signalling forces causes proliferation of chondrocytes without maturation. Ergo preventing sensence

https://sci-hub.se/10.1210/en.2004-1379
Ghrelin promotes high levels of cAMP which in high levels prevents maturation of chondrocytes.
https://pubmed.ncbi.nlm.nih.gov/17469134/

How this relates to ghrelin other effects on igf-1.

https://pmc.ncbi.nlm.nih.gov/articles/PMC7299241/?utm_source=chatgpt.com
https://pmc.ncbi.nlm.nih.gov/articles/PMC3530140/?utm_source=chatgpt.com

Igf-1 works by upregulating the current state of the growth plate
What do i mean by this

>Proliferative chondrocytes proliferate faster and hypertrophy faster
>In mesenchymal igf-1 makes them move towards becoming chondrocytes
>in prehypertrophic cells igf-1 cause them to mature fully into bone


Conclusion:
Hence forth if we shift the state of the growth plate towards proliferation rather than maturation we prolong the growing period even further.

 

[90averagness82dimorphism]

If you have anything to add please to this please add it

 

[Recession]

pubmed is a god send lowk

 

[Deleted Member 90088]

So how can we use this to looksmax?

 

[583858]

Ghrelin upregulate the effect of sox9 and col2 and Acan.
https://pubmed.ncbi.nlm.nih.gov/31421834/
The upregulation of these signalling forces causes proliferation of chondrocytes without maturation. Ergo preventing sensence

https://sci-hub.se/10.1210/en.2004-1379
Ghrelin promotes high levels of cAMP which in high levels prevents maturation of chondrocytes.
https://pubmed.ncbi.nlm.nih.gov/17469134/

How this relates to ghrelin other effects on igf-1.

https://pmc.ncbi.nlm.nih.gov/articles/PMC7299241/?utm_source=chatgpt.com
https://pmc.ncbi.nlm.nih.gov/articles/PMC3530140/?utm_source=chatgpt.com

Igf-1 works by upregulating the current state of the growth plate
What do i mean by this

>Proliferative chondrocytes proliferate faster and hypertrophy faster
>In mesenchymal igf-1 makes them move towards becoming chondrocytes
>in prehypertrophic cells igf-1 cause them to mature fully into bone


Conclusion:
Hence forth if we shift the state of the growth plate towards proliferation rather than maturation we prolong the growing period even further.

No

 

[90averagness82dimorphism]

So how can we use this to looksmax?

"height"