Hedgehog signaling Activator Compounds

[osteochondromyxoma]

Read My other Thread on Hedgehog Signaling​

1. Purmorphamine​

• Mechanism: Activates the Hh pathway via Smoothened receptor.
• Hypothetical Starting Dosage: Animal studies typically use doses that achieve plasma concentrations of around 0.5 to 10 µM. For a human, a very low starting dose would be required, gradually increasing while monitoring for side effects.

2. Smoothened Agonists (e.g., SAG)​

• Mechanism: Directly activates Smoothened, promoting Hh pathway activation.
• Hypothetical Starting Dosage: Similar to Purmorphamine, starting with a very low dose is crucial.

3. HH-Ag 1.5​

• Mechanism: Potent Hh pathway agonist, mimics natural Hh ligands.
• Hypothetical Starting Dosage: Start with a low dose to assess safety and monitor effects.

Example: 0.01 mg/kg/day.

tbh, wont replace hgh any day soon but it's possible to add in a stack in the future when research comes out with this shit for height.
PM if ur curious aobut soruces.
Sorry for bad thread i'm currently in europe just thought to share some things i've read over the past two weeks.

 

[osteochondromyxoma]

Also this shit is expensive, but purmorphamine seems to be a better option

 

[RAJ GHRANDHICK]

Didn't understand a single molecule

 

[Wilk]

Tf

 

[sigma]

good thread
under research tho
sounds promising