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How to increase androgen receptor sensitivity
What are androgen receptors
Androgen receptors are ligand-dependent nuclear transcription factors that act as binding sites for male hormones like testosterone and DHT (dihydrotestosterone) to regulate gene expression.
Androgen receptors are ligand-dependent nuclear transcription factors that act as binding sites for male hormones like testosterone and DHT (dihydrotestosterone) to regulate gene expression.
What is androgen receptor sensitivity?
Androgen receptor sensitivity refers to how responsive androgen receptors are to circulating hormones. This is influenced by how many CAG repeats there are in androgen receptor genes.
Androgen receptor sensitivity refers to how responsive androgen receptors are to circulating hormones. This is influenced by how many CAG repeats there are in androgen receptor genes.
Why do you want to increase your androgen receptor sensitivity?
Higher androgen receptor sensitivity amplifies the androgen-mediated pathways leading to stronger activation of mTOR, also maximizes anabolic effects from testosterone and DHT (dihydrotestosterone), and also leads to lower estrogen through higher free androgen bioavailability, which leads to reduced SHBG.
Androgen receptors also upregulate IGF-1R in chondrocytes, which leads to accelerated chondrocyte proliferation in epiphyseal plates, which means a stronger pubertal growth spurt.
Higher androgen receptor activity also suppresses aromatase, which reduces testosterone to estradiol conversion, which leads to a better estrogen-to-testosterone ratio.
Higher androgen receptor sensitivity amplifies the androgen-mediated pathways leading to stronger activation of mTOR, also maximizes anabolic effects from testosterone and DHT (dihydrotestosterone), and also leads to lower estrogen through higher free androgen bioavailability, which leads to reduced SHBG.
Androgen receptors also upregulate IGF-1R in chondrocytes, which leads to accelerated chondrocyte proliferation in epiphyseal plates, which means a stronger pubertal growth spurt.
Higher androgen receptor activity also suppresses aromatase, which reduces testosterone to estradiol conversion, which leads to a better estrogen-to-testosterone ratio.
How to increase androgen receptor sensitivity
Resistance training increases AR mRNA expression, phosphorylation increases androgen receptor density in muscle, and enhances coactivator recruitment.
High healthy fats and cholesterol: Cholesterol is a precursor for testosterone, which means higher substrate availability to support androgen signaling. Saturated fats upregulate androgen expression and reduce SHBG production in the liver.
Protein+carbs post-workout: protein especially high in leucine activates mTORC1, which increases AR mRNA expression and androgen protein synthesis in muscle cells. Carbs spike insulin, which binds to IGF-1 receptors and moves androgens into the cell nucleus faster.
Resistance training increases AR mRNA expression, phosphorylation increases androgen receptor density in muscle, and enhances coactivator recruitment.
High healthy fats and cholesterol: Cholesterol is a precursor for testosterone, which means higher substrate availability to support androgen signaling. Saturated fats upregulate androgen expression and reduce SHBG production in the liver.
Protein+carbs post-workout: protein especially high in leucine activates mTORC1, which increases AR mRNA expression and androgen protein synthesis in muscle cells. Carbs spike insulin, which binds to IGF-1 receptors and moves androgens into the cell nucleus faster.
Supplementation
Zinc 15mg: cofactor for a5-reductase
Creatine (preferably Creapure)5 g a day/ 0.1 g per kilo of body weight: raises DHT in muscle
Boron 3-6 mg: lowers SHBG (don't take if prone to hairloss)
L-Carnitine L-Tartrate 2-4 a day: increases androgen content in muscle tissue
Beta-Alanine 3-6 g a day: raises muscle carnosine
Zinc 15mg: cofactor for a5-reductase
Creatine (preferably Creapure)5 g a day/ 0.1 g per kilo of body weight: raises DHT in muscle
Boron 3-6 mg: lowers SHBG (don't take if prone to hairloss)
L-Carnitine L-Tartrate 2-4 a day: increases androgen content in muscle tissue
Beta-Alanine 3-6 g a day: raises muscle carnosine
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