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Guide How to increase cognitive ability

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i have actually eaten quite a bit of raw brain when i was full primal. its pretty good taste like egg yolk
 
bleeder said:
idk i dont wanna get sick and i cant imagine it tastes good
Click to expand...
tastes very similar u wont get sick. ive eaten fucking spoiled meat and supermarket meat and been fine
 
moewzerz said:
Eat brain.
Click to expand...
Eating brain tissue is generally discouraged in modern food safety and medical guidance. Although some cultures historically consumed brain as part of traditional dishes or rituals, the nervous system can contain pathogens that specifically target neural tissue, including prions. Because prions are unusually resistant to heat, digestion, and many sterilization processes, consuming contaminated brain tissue can pose a rare but serious neurological risk. For this reason, many public health regulations restrict or discourage the consumption of brain and other central nervous system tissues from animals.


The normal protein in the brain: PrPᶜ​


All humans naturally produce a protein called PrPᶜ (cellular prion protein). It is encoded by the PRNP gene and is found on the surface of many cells, especially neurons. Structurally, this protein is mainly composed of alpha-helices, which makes it soluble and easily broken down by enzymes.


Researchers believe PrPᶜ may play roles in neuronal protection, synaptic communication, and regulation of oxidative stress, although its precise physiological function is still being studied.


The abnormal form: PrPˢᶜ​


In prion diseases, this normal protein can adopt an abnormal conformation known as PrPˢᶜ. The amino-acid sequence remains the same; what changes is the three-dimensional folding of the protein.


This misfolded form differs from PrPᶜ in several ways:


  • it contains more β-sheet structure
  • it becomes insoluble
  • it is resistant to proteolytic degradation
  • it tends to aggregate into amyloid structures

A critical property of PrPˢᶜ is that it can act as a template, inducing normal PrPᶜ proteins to refold into the same pathological conformation.


What can happen if infected brain tissue is consumed​


If brain tissue containing PrPˢᶜ is ingested, the prions may survive the digestive process. After ingestion, several biological steps may occur.


First, prions can cross the intestinal barrier through structures such as M cells within Peyer’s patches in the gut-associated lymphoid tissue. They may then accumulate in peripheral lymphoid organs including lymph nodes, the spleen, and tonsils.


In these tissues, the abnormal protein continues converting host PrPᶜ into PrPˢᶜ. Over time, prions spread to the nervous system through peripheral nerves, often along autonomic pathways such as those involving the vagus nerve.


Effects once prions reach the brain​


When prions reach the central nervous system, the misfolding reaction accelerates. Increasing amounts of PrPᶜ convert into the abnormal form, leading to accumulation of aggregates within neural tissue.


The resulting pathological changes include:


  • neuronal loss
  • synaptic degeneration
  • astrocytic gliosis
  • formation of amyloid plaques

Microscopically, neurons develop vacuoles that give brain tissue a spongiform appearance. For this reason, these conditions are collectively called transmissible spongiform encephalopathies (TSEs).


Diseases associated with prions​


Examples of prion diseases include:


  • Kuru, historically linked to ritual consumption of human brain tissue
  • Creutzfeldt–Jakob disease (CJD)
  • variant CJD, associated with exposure to bovine spongiform encephalopathy (“mad cow disease”)

Clinical symptoms often include progressive cognitive decline, impaired coordination (ataxia), involuntary muscle jerks (myoclonus), and other severe neurological deficits.


Why prions are biologically unusual​


Prions are unique infectious agents because they contain no nucleic acids. Instead, they propagate solely through protein misfolding. They are also remarkably resistant to many physical and chemical treatments that normally destroy microorganisms.


Genetic susceptibility​


Although the disease mechanism itself is not a traditional genetic mutation, certain PRNP gene polymorphisms influence susceptibility. One well-studied example involves the polymorphism at codon 129, which affects how easily the pathological protein conversion occurs.
 
What if it is a dumb brain
 
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