dear Looksmaxxers...
originally i made this for school, but i figured it would be nice if i put this here too
This is a thread based on trustable sources with a full reasoning on how different diets can have different effects on IGF-1 bioavailability, thus improving growth.
i made this in italian, so i had to translate it with chatgpt so some stuff may be incorrect
EVENING CARBOHYDRATE CONCENTRATION VERSUS AN EVEN DISTRIBUTION THROUGHOUT THE DAY
WHICH HAS BETTER EFFECTS ON IGF-1?
INTRODUCTION
The goal is to prove that a diet characterized by a concentration of carbohydrates mainly at dinner causes a greater spike in insulin levels compared to a diet characterized by an even distribution of carbohydrates across the three daily meals.
Furthermore, it will be shown that higher insulin levels have a greater effect on the free (bioavailable) levels of the hormone responsible for height growth and other physical aspects, IGF-1.
A controlled study showed that postprandial insulin is higher after meals consumed in the evening/night compared to the morning, even with meals of similar calorie content and composition, because glucose levels are higher.
“The current study confirms that meal intake at night, even when comprised of low glycemic ingredients, contributes to higher glucose excursions and concomitantly greater insulin levels, compared with an equivalent meal in the morning..”
www.sciencedirect.com/science/article/abs/pii/S0261561417314085
Another study showed that glucose tolerance is worse in the evening, with higher insulin and blood glucose responses after evening meals compared to morning meals.
“Meta-analysis for glucose showed a lower postprandial glucose response in the day compared to during the night, after an identical meal (SMD = -1.66; 95% CI, -1.97 to -1.36; p < .001)...”
pubmed.ncbi.nlm.nih.gov/31782659/
Nutrition studies show that insulin sensitivity is lower in the evening compared to the daytime, and that large evening meals are associated with higher postprandial insulin compared to distributed meals. For HF/HC, a diet with fats in the first part of the day and carbohydrates in the second is indicated; HC/HF indicates the opposite.
“On the HF/HC diet, whole-day glucose level was increased by 7.9% (p = 0.026)On the HF/HC diet, whole-day glucose level was increased by 7.9% (p = 0.026)..”
“Effects of the HC/HF diet (solid lines) and the HF/HC diet (dotted lines)”
www.nature.com/articles/srep44170?
Therefore, a diet consisting of carbohydrate consumption mainly in the evening corresponds to a greater insulin spike, which occurs at the same time IGF-1 is produced.
“....Thus, insulin may play a role in determining the bioavailability of IGF-I.
https://pubmed.ncbi.nlm.nih.gov/7521354/
Studies in healthy subjects using glucose/insulin injections indicate that insulin modifies IGFBP-1 and IGFBP-3 (the protein responsible for transporting IGF-1 in the blood) and therefore influences free IGF-1 levels, even though total IGF-1 levels remain relatively constant.
“....In conclusion, free IGF-I is acutely regulated by insulin and correlates with SI, suggesting that it may play a physiological role in glucose homeostasis.”
pubmed.ncbi.nlm.nih.gov/9215291/
Therefore, insulin blocks the transcription and production of IGFBP-1. Less IGFBP-1 → more free IGF-1 available. Various studies show an inversely proportional relationship between insulin and IGFBP-1: higher insulin → greater IGFBP-1 suppression → more free IGF-1. (pubmed.ncbi.nlm.nih.gov/7521354/)
Additionally, the same studies in healthy subjects with insulin stimulation show that variations in the insulin peak also modify IGFBP-1 concentrations and, consequently, the free fraction of IGF-1. (pubmed.ncbi.nlm.nih.gov/7521354/)
Therefore, insulin levels have a direct effect on free IGF-1 levels, increasing them by decreasing IGFBP-1 levels.
CONCLUSION
In conclusion, it can be stated that a diet consisting mainly of carbohydrates at an evening meal causes an insulin spike during the night, which, occurring at the same time IGF-1 is primarily produced, directly influences free IGF-1 levels by blocking the release and production of IGFBP-1.
originally i made this for school, but i figured it would be nice if i put this here too
This is a thread based on trustable sources with a full reasoning on how different diets can have different effects on IGF-1 bioavailability, thus improving growth.
i made this in italian, so i had to translate it with chatgpt so some stuff may be incorrect
EVENING CARBOHYDRATE CONCENTRATION VERSUS AN EVEN DISTRIBUTION THROUGHOUT THE DAY
WHICH HAS BETTER EFFECTS ON IGF-1?
INTRODUCTION
The goal is to prove that a diet characterized by a concentration of carbohydrates mainly at dinner causes a greater spike in insulin levels compared to a diet characterized by an even distribution of carbohydrates across the three daily meals.
Furthermore, it will be shown that higher insulin levels have a greater effect on the free (bioavailable) levels of the hormone responsible for height growth and other physical aspects, IGF-1.
- Carbohydrate timing: evening meals high in carbohydrates → more pronounced (temporary) insulin spikes.
A controlled study showed that postprandial insulin is higher after meals consumed in the evening/night compared to the morning, even with meals of similar calorie content and composition, because glucose levels are higher.
“The current study confirms that meal intake at night, even when comprised of low glycemic ingredients, contributes to higher glucose excursions and concomitantly greater insulin levels, compared with an equivalent meal in the morning..”
www.sciencedirect.com/science/article/abs/pii/S0261561417314085
Another study showed that glucose tolerance is worse in the evening, with higher insulin and blood glucose responses after evening meals compared to morning meals.
“Meta-analysis for glucose showed a lower postprandial glucose response in the day compared to during the night, after an identical meal (SMD = -1.66; 95% CI, -1.97 to -1.36; p < .001)...”
pubmed.ncbi.nlm.nih.gov/31782659/
Nutrition studies show that insulin sensitivity is lower in the evening compared to the daytime, and that large evening meals are associated with higher postprandial insulin compared to distributed meals. For HF/HC, a diet with fats in the first part of the day and carbohydrates in the second is indicated; HC/HF indicates the opposite.
“On the HF/HC diet, whole-day glucose level was increased by 7.9% (p = 0.026)On the HF/HC diet, whole-day glucose level was increased by 7.9% (p = 0.026)..”
“Effects of the HC/HF diet (solid lines) and the HF/HC diet (dotted lines)”
www.nature.com/articles/srep44170?
Therefore, a diet consisting of carbohydrate consumption mainly in the evening corresponds to a greater insulin spike, which occurs at the same time IGF-1 is produced.
- Insulin → effects on IGF-1 bioavailability
“....Thus, insulin may play a role in determining the bioavailability of IGF-I.
https://pubmed.ncbi.nlm.nih.gov/7521354/
Studies in healthy subjects using glucose/insulin injections indicate that insulin modifies IGFBP-1 and IGFBP-3 (the protein responsible for transporting IGF-1 in the blood) and therefore influences free IGF-1 levels, even though total IGF-1 levels remain relatively constant.
“....In conclusion, free IGF-I is acutely regulated by insulin and correlates with SI, suggesting that it may play a physiological role in glucose homeostasis.”
pubmed.ncbi.nlm.nih.gov/9215291/
Therefore, insulin blocks the transcription and production of IGFBP-1. Less IGFBP-1 → more free IGF-1 available. Various studies show an inversely proportional relationship between insulin and IGFBP-1: higher insulin → greater IGFBP-1 suppression → more free IGF-1. (pubmed.ncbi.nlm.nih.gov/7521354/)
Additionally, the same studies in healthy subjects with insulin stimulation show that variations in the insulin peak also modify IGFBP-1 concentrations and, consequently, the free fraction of IGF-1. (pubmed.ncbi.nlm.nih.gov/7521354/)
Therefore, insulin levels have a direct effect on free IGF-1 levels, increasing them by decreasing IGFBP-1 levels.
CONCLUSION
In conclusion, it can be stated that a diet consisting mainly of carbohydrates at an evening meal causes an insulin spike during the night, which, occurring at the same time IGF-1 is primarily produced, directly influences free IGF-1 levels by blocking the release and production of IGFBP-1.
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