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Meclozine is something that has come onto the show more recently and it could seriously help you maximize gene potenial in epiphyseal chrondrocytes. I’ll discuss a article and the mechanism of Meclozine.
What is Meclozine?
It’s a simple antihistamine that has same functions such as other antihistamines such as popular ones as Benadryl. Yet sometimes it’s used more for motion sickness rather than allergies.
pubmed.ncbi.nlm.nih.gov
This article from pubmed shows that mice dosed with 2mg/kg turned out to have a longer stature despite having achondroplasia (ACH).
Can we start something with this? Yes. Let’s look at what happened to these mice first.
Here it’s shown the difference between untreated and treated with Meclozine alone. The relative body length of the mice treated with Meclozine is far superior than the mice without treatment despite same age.
Here you can see a close of chondrocyte activity difference between an untreated mice,treated mice with a lower dose and another with a higher dose. There’s a clear difference between them and now we’ll discuss what does it actually do?
Mechanism:In this article,it’s shown that mice with achondroplasia which directly overstimulates Fgfr3,Meclozine directly inhibits Fgfr3 for the mice which directly increased chondrocyte proliferation. You don’t need have a gene mutation of Fgfr3 for this to work,we all Fgfr3 activity to certain degree. Fgfr3 stands for fibroblast growth factor receptor 3,one of the main inhibitors of chondrocyte proliferation.
Does it work on humans? The epiphyseal plate,mechanism and functions of mice is very close to the ones of humans. In theory it should have the same mechanism for humans,more potently if paired with other compounds.
For maximum gene expression? Pair it with HGH,insulin,T4 and Anavar.
What is Meclozine?
It’s a simple antihistamine that has same functions such as other antihistamines such as popular ones as Benadryl. Yet sometimes it’s used more for motion sickness rather than allergies.
Clinical dosage of meclozine promotes longitudinal bone growth, bone volume, and trabecular bone quality in transgenic mice with achondroplasia - PubMed
Achondroplasia (ACH) is the most common short-limbed skeletal dysplasia caused by gain-of-function mutations in the fibroblast growth factor receptor 3 (FGFR3). No effective FGFR3-targeted therapies for ACH are currently available. By drug repositioning strategies, we identified that meclozine...
pubmed.ncbi.nlm.nih.gov
Can we start something with this? Yes. Let’s look at what happened to these mice first.
Here it’s shown the difference between untreated and treated with Meclozine alone. The relative body length of the mice treated with Meclozine is far superior than the mice without treatment despite same age.
Here you can see a close of chondrocyte activity difference between an untreated mice,treated mice with a lower dose and another with a higher dose. There’s a clear difference between them and now we’ll discuss what does it actually do?
Mechanism:In this article,it’s shown that mice with achondroplasia which directly overstimulates Fgfr3,Meclozine directly inhibits Fgfr3 for the mice which directly increased chondrocyte proliferation. You don’t need have a gene mutation of Fgfr3 for this to work,we all Fgfr3 activity to certain degree. Fgfr3 stands for fibroblast growth factor receptor 3,one of the main inhibitors of chondrocyte proliferation.
Does it work on humans? The epiphyseal plate,mechanism and functions of mice is very close to the ones of humans. In theory it should have the same mechanism for humans,more potently if paired with other compounds.
For maximum gene expression? Pair it with HGH,insulin,T4 and Anavar.
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