News Mk677 test on rats. Lmk what u think

[howtomogg]

“Oral administration of MK-677 at 4 mg/kg increased peak GH concentrations by 1.8-fold, compared to baseline. However, oral administration of MK-677 for 6 weeks did not increase body growth or serum levels of IGF-I. At 6 weeks after treatment, the GH response to MK-677 was abolished. Pituitary GH mRNA and hypothalamic GH-releasing hormone mRNA, and GH secretagogue receptor (GHSR) mRNA expression in the pituitary and hypothalamus did not differ between the control and treatment group. Somatostatin (SST) mRNA expression in the hypothalamus was markedly increased in the treatment group, whereas SST receptor (SSTR)-2 mRNA expression in the pituitary gland was decreased. Protein expression of hypothalamic GHSR, SST, and pituitary SSTR-2 showed patterns similar to those for mRNA expression.“

Effect of the Orally Active Growth Hormone Secretagogue MK-677 on Somatic Growth in Rats - PubMed

Our results suggest that prolonged administration of MK-677 in rats does not promote growth despite the GH stimulatory effect of MK-677, which may be related to increased expression of SST in the hypothalamus. Further studies are needed to overcome the observed desensitization to GHS.

pubmed.ncbi.nlm.nih.gov

 

[Whitepill]

explain for low iq like me

 

[howtomogg]

explain for low iq like me

It seems like they’re saying it only boosted the gh levels and not any other igf1 or serum. But thats either false or its because it was done on rats
“MK-677 oral administration increased peak GH concentrations by 1.8-fold, but did not increase body growth or serum IGF-I levels. At 6 weeks, the GH response was abolished, and mRNA expression in the pituitary and hypothalamus did not differ between the control and treatment groups.” ai summary

 

[Whitepill]

explain for

It seems like they’re saying it only boosted the gh levels and not any other igf1 or serum. But thats either false or its because it was done on rats
“MK-677 oral administration increased peak GH concentrations by 1.8-fold, but did not increase body growth or serum IGF-I levels. At 6 weeks, the GH response was abolished, and mRNA expression in the pituitary and hypothalamus did not differ between the control and treatment groups.” ai summary

id go with the second option rats aren’t really close enough to humans to gauge results off of

 

[howtomogg]

explain for

id go with the second option rats aren’t really close enough to humans to gauge results off of

GH directly and through IGF-I stimulates osteoblast proliferation and activity, promoting bone formation. It also stimulates osteoclast differentiation and activity, promoting bone resorption. The result is an increase in the overall rate of bone remodeling, with a net effect of bone accumulation. True

 

[Rkelly]

Ignore the rodent models and go for the human trials

 

[Whitepill]

Ignore the rodent models and go for the human trials

Have they had any yet?

 

[Rkelly]

Have they had any yet?

Absolutely, iirc there was one even back in 1998

 

[Whitepill]

Were the results similar to these rats?

Absolutely, iirc there was one even back in 1998

 

[sigma]

“Oral administration of MK-677 at 4 mg/kg increased peak GH concentrations by 1.8-fold, compared to baseline. However, oral administration of MK-677 for 6 weeks did not increase body growth or serum levels of IGF-I. At 6 weeks after treatment, the GH response to MK-677 was abolished. Pituitary GH mRNA and hypothalamic GH-releasing hormone mRNA, and GH secretagogue receptor (GHSR) mRNA expression in the pituitary and hypothalamus did not differ between the control and treatment group. Somatostatin (SST) mRNA expression in the hypothalamus was markedly increased in the treatment group, whereas SST receptor (SSTR)-2 mRNA expression in the pituitary gland was decreased. Protein expression of hypothalamic GHSR, SST, and pituitary SSTR-2 showed patterns similar to those for mRNA expression.“

Effect of the Orally Active Growth Hormone Secretagogue MK-677 on Somatic Growth in Rats - PubMed

Our results suggest that prolonged administration of MK-677 in rats does not promote growth despite the GH stimulatory effect of MK-677, which may be related to increased expression of SST in the hypothalamus. Further studies are needed to overcome the observed desensitization to GHS.

pubmed.ncbi.nlm.nih.gov

Let me try to break this down if I understand:
1 group of rats given MK677: GH increased 1.8x compared to original number. but no effect on body growth. After 6 weeks the GH stopped being produced, so perhaps the rats grew tolerant of it and now it does not work. mRNA expression for some hormones and hormone receptors did not change. idk what sometostating is, but its production increased while the making of the receptors decreased.
So basically MK677 will work in 6 week cycles. I think if you do that then take a break and repeat it might work. But no body growth and some mRNA shenanigans

 

[Rkelly]

Were the results similar to these rats?

Don’t remember the exact numbers id have to check.

 

[Whitepill]

Let me try to break this down if I understand:
1 group of rats given MK677: GH increased 1.8x compared to original number. but no effect on body growth. After 6 weeks the GH stopped being produced, so perhaps the rats grew tolerant of it and now it does not work. mRNA expression for some hormones and hormone receptors did not change. idk what sometostating is, but its production increased while the making of the receptors decreased.
So basically MK677 will work in 6 week cycles. I think if you do that then take a break and repeat it might work. But no body growth and some mRNA shenanigans

Jova for rat heightmaxxers

 

[sigma]

Don’t remember the exact numbers id have to check.

how did you become knowledgable? you are very smart and obv deserve the badge, but is the process subjective and what specific thing did you do to get it?

 

[Whitepill]

how did you become knowledgable? you are very smart and obv deserve the badge, but is the process subjective and what specific thing did you do to get it?

He’s experienced

 

[Whitepill]

He’s been on this forum for 5 years and .org for 4

 

[Rkelly]

how did you become knowledgable? you are very smart and obv deserve the badge, but is the process subjective and what specific thing did you do to get it?

I actually don’t know, I’m assuming the admin gives them out. I didn’t ask for it or get any notification of it so I’m not sure what the exact process is. My best guess would be to consistently exhibit above average knowledge on topics relevant to this forum.

 

[howtomogg]

Let me try to break this down if I understand:
1 group of rats given MK677: GH increased 1.8x compared to original number. but no effect on body growth. After 6 weeks the GH stopped being produced, so perhaps the rats grew tolerant of it and now it does not work. mRNA expression for some hormones and hormone receptors did not change. idk what sometostating is, but its production increased while the making of the receptors decreased.
So basically MK677 will work in 6 week cycles. I think if you do that then take a break and repeat it might work. But no body growth and some mRNA shenanigans

I love you( no diddy)

 

[sigma]

I actually don’t know, I’m assuming the admin gives them out. I didn’t ask for it or get any notification of it so I’m not sure what the exact process is. My best guess would be to consistently exhibit above average knowledge on topics relevant to this forum.

alr, thanks for telling me tho

 

[sigma]

I love you( no diddy)

love you too pooks