Hypothesis nose pulling to fix nasal asymmetry (HIGH IQ)

[Leitung]

This is just a theory, but it's a nice cope for me. So I'll explain what I'm going to try and see if its worth a shit at all.

Many people advise against using tensile force to reshape/bend cartilage, but the truth is-no matter what people may say is that cartilage is malleable in some capacity. While maybe it can't be changed through one or two DIY remedies that you do for a while then drop in a week, but perhaps it can be changed through consistent pressure pushing it in the right direction, and influencing the cartilage to move over months of constant pressure.

1. The potential possibilities, and what you may stand to gain

• Through a phenomenon known as mechanotransduction, constant stress and applied force over a duration of months or years, cartilage CAN remodel, if even by a few millimeters.
• First off, to understand cartilage and the foundation of this theory you must understand the extracellular matrix (ECM), which composes most of the cartilage, providing structural support, mechanical resilience and biochemical signaling. The ECM is primarily made of collagen II fibers that resist tension, and proteoglycans that retain water to resist compression. ECM is the main structural contributor to "cartilage memory" and why under normal circumstances the nose isn't transformable.
• Briefing on mechanotransduction, summarized it works through receptors such as Integrins (primary force transmitters linking ECM to cytoskeleton), Syndecan-4 (modulates Integrins signaling), Ion channels (stretch-activated channels) on the cell surface detecting external mechanical stimuli (tensile, compressive, or other forces) and experiencing force-induced conformational change, which initiates intracellular signaling to start rearrangement and sending microtubules and actin filaments to the nucleus, affecting nuclear structure. The nuclear response being: mechanical cues which alter nuclear lamina, and affecting binding proteins which ultimately lead to new protein synthesis or cellular differentiation (large-scale chondrocytes proliferation isn't common in adult nasal cartilage, so cellular differentiation is used lightly), These phenomenon fundamentally change cartilage structure. While large-scale proliferation of chondrocytes is uncommon in adult nasal cartilage, mechanotransduction may also slightly stimulate resident progenitor cells, allowing very limited aspects of chondrogenesis to occur, which could contribute to subtle ECM remodeling over long periods.

2. Limitations

• As mention briefly, large-scale proliferation is uncommon in adults.. and highly theoretical. While it is true that mechanical stimuli can change nose cartilage, the position or way it changes and adapts may not be how you intend. Even if you accomplish some change, it could only be a few submilimeters, which is why this needs to be tested and proved that it can practically change your nose.

3. Key takeaways

• Mechanotransduction can alter ECM composition, collagen fiber orientation, and proteoglycan density which results in changes to cartilage microstructure.
• Resident progenitor cells may undergo minimal differentiation, adding a limited contribution to chrondrogenesis.
• Any changes in adult nasal cartilage are expected to be slow, minimal and highly variable. However, gradual reshaping via sustained mechanical stress is very possible.

4. Methods

• With my knowledge on the subject, I've created some experimental ways I can implement this realistically. We'll start with topical agents that may be able to increase malleability in the nose.
• Topically, you could use a generous amount of tret or traz to increase collagen turnover and potentially increasing elasticity. If used in conjunction with micro needling, it can increase the benefits of the retinoid. NOTE: TRET DOES NOT REMODEL CARTILAGE. What it can do is assist in increasing collagen synthesis and aiding in the restructuring process.
• The main contributor to remodeling is using splints or nose clips to move your nose in the desired direction. Right now, my nose has a slight deviation to the right. What I've been doing for about a week now is clipping a shoe string to my nose at night and tying it behind my ear, so at night it's constantly moving to the opposite side.
• Nose bending with your fingers can aid in the already constant pressure being issued nightly, if you do it 2x a day, in the morning and the evening. I put my fingers in both my nostrils and bend it hard to the opposite side as far as I can, about 3x for 30 seconds. Act as if you're trying to break your nose.

5. Potential enhancements

• If one of you can find a way to break the cartilage in a similar way that rhinoplasty does, this will become much more noticeable and happen over a shorter amount of time. However, I haven't looked into this as it would be quite dangerous to implement.

 

[vivi]

This is just a theory, but it's a nice cope for me. So I'll explain what I'm going to try and see if its worth a shit at all.

Many people advise against using tensile force to reshape/bend cartilage, but the truth is-no matter what people may say is that cartilage is malleable in some capacity. While maybe it can't be changed through one or two DIY remedies that you do for a while then drop in a week, but perhaps it can be changed through consistent pressure pushing it in the right direction, and influencing the cartilage to move over months of constant pressure.

1. The potential possibilities, and what you may stand to gain

• Through a phenomenon known as mechanotransduction, constant stress and applied force over a duration of months or years, cartilage CAN remodel, if even by a few millimeters.
• First off, to understand cartilage and the foundation of this theory you must understand the extracellular matrix (ECM), which composes most of the cartilage, providing structural support, mechanical resilience and biochemical signaling. The ECM is primarily made of collagen II fibers that resist tension, and proteoglycans that retain water to resist compression. ECM is the main structural contributor to "cartilage memory" and why under normal circumstances the nose isn't transformable.
• Briefing on mechanotransduction, summarized it works through receptors such as Integrins (primary force transmitters linking ECM to cytoskeleton), Syndecan-4 (modulates Integrins signaling), Ion channels (stretch-activated channels) on the cell surface detecting external mechanical stimuli (tensile, compressive, or other forces) and experiencing force-induced conformational change, which initiates intracellular signaling to start rearrangement and sending microtubules and actin filaments to the nucleus, affecting nuclear structure. The nuclear response being: mechanical cues which alter nuclear lamina, and affecting binding proteins which ultimately lead to new protein synthesis or cellular differentiation (large-scale chondrocytes proliferation isn't common in adult nasal cartilage, so cellular differentiation is used lightly), These phenomenon fundamentally change cartilage structure. While large-scale proliferation of chondrocytes is uncommon in adult nasal cartilage, mechanotransduction may also slightly stimulate resident progenitor cells, allowing very limited aspects of chondrogenesis to occur, which could contribute to subtle ECM remodeling over long periods.

2. Limitations

• As mention briefly, large-scale proliferation is uncommon in adults.. and highly theoretical. While it is true that mechanical stimuli can change nose cartilage, the position or way it changes and adapts may not be how you intend. Even if you accomplish some change, it could only be a few submilimeters, which is why this needs to be tested and proved that it can practically change your nose.

3. Key takeaways

• Mechanotransduction can alter ECM composition, collagen fiber orientation, and proteoglycan density which results in changes to cartilage microstructure.
• Resident progenitor cells may undergo minimal differentiation, adding a limited contribution to chrondrogenesis.
• Any changes in adult nasal cartilage are expected to be slow, minimal and highly variable. However, gradual reshaping via sustained mechanical stress is very possible.

4. Methods

• With my knowledge on the subject, I've created some experimental ways I can implement this realistically. We'll start with topical agents that may be able to increase malleability in the nose.
• Topically, you could use a generous amount of tret or traz to increase collagen turnover and potentially increasing elasticity. If used in conjunction with micro needling, it can increase the benefits of the retinoid. NOTE: TRET DOES NOT REMODEL CARTILAGE. What it can do is assist in increasing collagen synthesis and aiding in the restructuring process.
• The main contributor to remodeling is using splints or nose clips to move your nose in the desired direction. Right now, my nose has a slight deviation to the right. What I've been doing for about a week now is clipping a shoe string to my nose at night and tying it behind my ear, so at night it's constantly moving to the opposite side.
• Nose bending with your fingers can aid in the already constant pressure being issued nightly, if you do it 2x a day, in the morning and the evening. I put my fingers in both my nostrils and bend it hard to the opposite side as far as I can, about 3x for 30 seconds. Act as if you're trying to break your nose.

5. Potential enhancements

• If one of you can find a way to break the cartilage in a similar way that rhinoplasty does, this will become much more noticeable and happen over a shorter amount of time. However, I haven't looked into this as it would be quite dangerous to implement.

is this theory or are you seeing improvement

 

[Leitung]

is this theory or are you seeing improvement

I've started this week, so for now it's just theory. I'll be updating on my journey later, but there's many papers that back the research I've done on the subject so I'm expecting to see improvements within a couple months continuing. Of course, the anecdote of one person doesn't do much to improve the theory so I'm hoping that this could get recognition and others may try regardless of how arbitrary it seems

 

[LaWi]

Very interesting

 

[burnmyskin]

This is just a theory, but it's a nice cope for me. So I'll explain what I'm going to try and see if its worth a shit at all.

Many people advise against using tensile force to reshape/bend cartilage, but the truth is-no matter what people may say is that cartilage is malleable in some capacity. While maybe it can't be changed through one or two DIY remedies that you do for a while then drop in a week, but perhaps it can be changed through consistent pressure pushing it in the right direction, and influencing the cartilage to move over months of constant pressure.

1. The potential possibilities, and what you may stand to gain

• Through a phenomenon known as mechanotransduction, constant stress and applied force over a duration of months or years, cartilage CAN remodel, if even by a few millimeters.
• First off, to understand cartilage and the foundation of this theory you must understand the extracellular matrix (ECM), which composes most of the cartilage, providing structural support, mechanical resilience and biochemical signaling. The ECM is primarily made of collagen II fibers that resist tension, and proteoglycans that retain water to resist compression. ECM is the main structural contributor to "cartilage memory" and why under normal circumstances the nose isn't transformable.
• Briefing on mechanotransduction, summarized it works through receptors such as Integrins (primary force transmitters linking ECM to cytoskeleton), Syndecan-4 (modulates Integrins signaling), Ion channels (stretch-activated channels) on the cell surface detecting external mechanical stimuli (tensile, compressive, or other forces) and experiencing force-induced conformational change, which initiates intracellular signaling to start rearrangement and sending microtubules and actin filaments to the nucleus, affecting nuclear structure. The nuclear response being: mechanical cues which alter nuclear lamina, and affecting binding proteins which ultimately lead to new protein synthesis or cellular differentiation (large-scale chondrocytes proliferation isn't common in adult nasal cartilage, so cellular differentiation is used lightly), These phenomenon fundamentally change cartilage structure. While large-scale proliferation of chondrocytes is uncommon in adult nasal cartilage, mechanotransduction may also slightly stimulate resident progenitor cells, allowing very limited aspects of chondrogenesis to occur, which could contribute to subtle ECM remodeling over long periods.

2. Limitations

• As mention briefly, large-scale proliferation is uncommon in adults.. and highly theoretical. While it is true that mechanical stimuli can change nose cartilage, the position or way it changes and adapts may not be how you intend. Even if you accomplish some change, it could only be a few submilimeters, which is why this needs to be tested and proved that it can practically change your nose.

3. Key takeaways

• Mechanotransduction can alter ECM composition, collagen fiber orientation, and proteoglycan density which results in changes to cartilage microstructure.
• Resident progenitor cells may undergo minimal differentiation, adding a limited contribution to chrondrogenesis.
• Any changes in adult nasal cartilage are expected to be slow, minimal and highly variable. However, gradual reshaping via sustained mechanical stress is very possible.

4. Methods

• With my knowledge on the subject, I've created some experimental ways I can implement this realistically. We'll start with topical agents that may be able to increase malleability in the nose.
• Topically, you could use a generous amount of tret or traz to increase collagen turnover and potentially increasing elasticity. If used in conjunction with micro needling, it can increase the benefits of the retinoid. NOTE: TRET DOES NOT REMODEL CARTILAGE. What it can do is assist in increasing collagen synthesis and aiding in the restructuring process.
• The main contributor to remodeling is using splints or nose clips to move your nose in the desired direction. Right now, my nose has a slight deviation to the right. What I've been doing for about a week now is clipping a shoe string to my nose at night and tying it behind my ear, so at night it's constantly moving to the opposite side.
• Nose bending with your fingers can aid in the already constant pressure being issued nightly, if you do it 2x a day, in the morning and the evening. I put my fingers in both my nostrils and bend it hard to the opposite side as far as I can, about 3x for 30 seconds. Act as if you're trying to break your nose.

5. Potential enhancements

• If one of you can find a way to break the cartilage in a similar way that rhinoplasty does, this will become much more noticeable and happen over a shorter amount of time. However, I haven't looked into this as it would be quite dangerous to implement.

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