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n*****s really don’t understand,that estradiol (E2) can be tissue localized or circulatory (systemic). A aromatase inhibitor will mainly target your circulatory estradiol or tissues such as adipose tissue,since it’s the easiest shot for antagonism rather than tissues that can’t be fully saturated with it such as the epiphyseal plate. And your body compensates,simply because your body doesn’t want to unnecessarily get rid of hormones so in theory:
-Circulatory estradiol downregulates. (via aromasin)
-Localized estradiol upregulates back to its normal level. (epiphyseal plate)
The aromatization happens locally,it doesn’t reach your blood first then gets transferred to tissue.
Even if you manage to inhibit the Aromatese enzyme locally,the co factor localized estradiol enzymes in the epiphyseal plate will upregulate and compensation for the lack of aromatization,such as HSD17B1, 7 and 4. This way the lack of Aromatese will be compensated by e1->e2 conversion. After a while this conversion can downregulate and eventually cause your chondrocytes to slow down proliferation.
E2 just finishes the plate fusion,inhibiting it won’t really cause it to grow for longer periods but rather just halt total growth till you have ideal levels again. The reason why I tell people to not play around with AI when they’re not on test is because they’re blindly lowering the levels,they don’t already know their natural baseline level which could lower e2 too much.
-Circulatory estradiol downregulates. (via aromasin)
-Localized estradiol upregulates back to its normal level. (epiphyseal plate)
The aromatization happens locally,it doesn’t reach your blood first then gets transferred to tissue.
Even if you manage to inhibit the Aromatese enzyme locally,the co factor localized estradiol enzymes in the epiphyseal plate will upregulate and compensation for the lack of aromatization,such as HSD17B1, 7 and 4. This way the lack of Aromatese will be compensated by e1->e2 conversion. After a while this conversion can downregulate and eventually cause your chondrocytes to slow down proliferation.
E2 just finishes the plate fusion,inhibiting it won’t really cause it to grow for longer periods but rather just halt total growth till you have ideal levels again. The reason why I tell people to not play around with AI when they’re not on test is because they’re blindly lowering the levels,they don’t already know their natural baseline level which could lower e2 too much.
