Guide An Introduction to Androgens/Growth factors - The Ultimate Guide to PUBERTYMAXXING **WITH STUDIES**

[Jimcel]

An Introduction to Androgens/Growth factors - The Ultimate Guide to PUBERTYMAXXING **WITH STUDIES**


Preface:

This thread is made under the presumption you are still undergoing puberty which usually ranges from ages 11-17 but can start earlier/end later depending on genetics. You can check if you are still in puberty by getting an X-ray scan on your left hand/wrist to see if growth plates are still open.​

Introduction:

I will be explaining growth-inducing lifestyle habits (diet and sleep) and how to utilise Growth factors/ androgens to get the most facial development, increased sexual dimorphism and vertical growth out of puberty.

Lifestyle habits:

Habits during adolescence are underrated when it comes to development. Although they may not be as effective as other methods mentioned, it is
still necessary.

The ideal habits include:

8 Hours + sleep
Adequate hydration (<3L water)
Daily exercise (gym or martial art + some cardio)
Maintain proper posture

Diet:

The optimal diet won’t yield crazy results but is a staple to your protocol as a whole

The optimal diet consists of:

Wholefoods only - greater nutrient density to support hormonal function + skeletal development
300-500 calorie surplus - high energy availability for thyroid function and growth
Protein 1.2-2.2 g/kg bodyweight - supplements muscle/bone growth
Carbohydrates 3-6k/kg/day - provides energy for growth, performance and maintain glycogen stores
Red meat 3-7 times per week - most nutrient dense food for male development
Dairy - Increases IGF-1 and supports bone mineralization
Vitamin D - allows efficient calcium absorption
Healthy fats - supports hormone production (NOT NECESSARY ON AAS)
Zinc -Supports hormone function

Make a diet following these principles - use ChatGPT for this if you are struggling

Testosterone:

Disclaimer: if not managed properly, this can accelerate the fusion of growth plates

Testosterone is the primary androgen driving male puberty. It fuels muscle growth, bone density and width, voice deepening, facial masculinization, body hair, libido, and overall sexual dimorphism. Levels rise sharply from Tanner 2 onward and peak in late puberty.

The best way to increase test is to pick up the needle: Test E 350mg/week

Side effects:

Bloating
Gyno
Higher libido
Increased aggression
Hair loss
Increased blood pressure

Note: These sides are less likely on a dose of 350mg

I will make a thread simplifying every from sourcing to injecting and managing sides soon, but do you own research before proceeding.

Study on effect of low dose test on boys with delayed puberty https://www.researchgate.net/publication/12970434_Effect_of_low-dose_testosterone_treatment_on_craniofacial_growth_in_boys_with_delayed_puberty​

Craniofacial growth was investigated in boys treated with low-dose testosterone for delayed puberty (> 14 years old; testicular volume < 4 ml; n = 7) and compared with controls (12-14 years; n = 37). Cephalometric radiographs, statural height and pubertal stage were recorded at the start of the study and after 1 year. Craniofacial growth was assessed by nine linear measurements. At the beginning of the study, statural height, mandibular ramus length, upper anterior face height, and total cranial base length were significantly shorter in the delayed puberty boys than in the controls. After 1 year, the growth rate of the statural height, total mandibular length, ramus length, and upper and total anterior face height was significantly higher in the treated boys than in the untreated height-matched controls (n = 7). The craniofacial measurements were similar in the treated boys as compared with the controls. These results show that statural height and craniofacial dimensions are low in boys with delayed puberty. Low doses of testosterone accelerate statural and craniofacial growth, particularly in the delayed components, thus leading towards a normalization of facial dimensions.​

Trenbolone:

Disclaimer: if not managed properly, this can accelerate the fusion of growth plates and can negatively impact your health.

Trenbolone is a highly potent synthetic anabolic-androgenic steroid (AAS) originally developed for veterinary use. It is not approved for medical use in humans. It binds strongly to the androgen receptor and has powerful anabolic and androgenic effects.

I would strongly advise staying on low dose as anything more is a looksmin in my opinion:: Trenbolone Acetate 25mg.

Side effects:

Night sweats
Insomnia
Increased heart rate
Appetite suppression
Cough (AKA tren cough)
Increased prolactin
Kidney stress
Tren rage

Note: only use this compound towards the very end or a little bit after puberty.

As previously mentioned, A thread on this is due but also do your own research on these compounds.

Study on impact of trenbolone: https://journals.viamedica.pl/endokrynologia_polska/article/view/99130​

Skeletal muscle hypertrophy. AR—androgen receptor; ARE—androgen response element; β-c—β-catenin; FGF—fibroblast growth factor; GPCR—G protein-related receptor; GSK-1—glycogen synthase kinase 1; IGF-1—insulin-like growth factor 1; MC—myosatellite cell; NICD—Notch intracellular domain; Notch—Notch signalling pathway; Tcf2/Lef—transcriptional repressors/activators; Wnt—Wnt signalling pathway.

Dihydrotestosterone (DHT):

Dihydrotestosterone (DHT) is a potent androgen produced from testosterone by the enzyme 5α-reductase in specific tissues (skin, hair follicles, prostate, genitals). It binds the androgen receptor more strongly than testosterone and does not aromatize into estrogen. It plays a smaller role in muscle growth compared to testosterone but is highly important for sexual dimorphism in hair and genital tissues.

Effective ways to increase DHT (listed from most direct to least):

Direct DHT or strong DHT-derivatives (e.g. topical DHT, Masteron/drostanolone, Proviron/mesterolone)
Higher testosterone base (more substrate for conversion via 5α-reductase)
Supporting 5α-reductase activity: adequate zinc, boron, and overall androgen status

Side effects:

Accelerated male-pattern hair loss (if genetically prone)
Increased body/facial hair
Acne / oily skin
Prostate stimulation (possible enlargement or higher PSA in susceptible individuals)
Potential negative impact on cholesterol with stronger DHT compounds
Suppression of natural hormone production when using exogenous DHT derivatives

Study of Dihydrotestosterone induces a sexual dimorphism in oestrogen uptake by specific anterior pituitary cell types in vivo: https://pubmed.ncbi.nlm.nih.gov/3621311/​

DHT pre-treatment, however, caused a significant decrease in 3H-E2 retention by gonadotrophs in both males and females. The treatment also caused a decrease in binding by lactotrophs and somatotrophs, but only in the females. No other cell types were altered. Thus, androgen appears to modulate E2 binding and retention by pituitary cells in both a cell-type and sex-dependent manner. Our results also indicate that the inhibitory effects of androgens on E2 binding by the pituitary gland is more complex than can be explained by simple competition for the oestrogen receptor.​

HGH/IGF-1:

Human Growth Hormone (HGH) or somatotropin, is a peptide hormone produced by the anterior pituitary gland. It plays a crucial role in growth, tissue repair, metabolism, and body composition by directly affecting tissues and stimulating the production of insulin-like growth factor-1 (IGF-1), primarily in the liver. Insulin-Like Growth Factor 1 is an anabolic peptide hormone acts as the primary downstream mediator of many of HGH's growth-promoting effects and is also essential for normal skeletal growth, tissue repair, and muscle development.

Effective ways to increase HGH/IGF-1 (listed from most effective to least effective)

HGH - 6-8 IUs ED
GHRP2/6 - 100mcg each 3x a day
IGFLR3 40-50mcg twice a day
Mk677 (cheapest + oral) - 15mg ED

Side effects:

Water retention
Insulin retention
Carpal tunnel symptoms
acceleration of moles
Joint pain

Note: some of these sides are only common with HGH, the other options are less risky.

Study of regulation of muscle mass by growth hormone and IGF-1: https://pmc.ncbi.nlm.nih.gov/articles/PMC2439518/?utm_source​

concluded that the GH/IGF-1 axis is a central regulator of muscle growth and that IGF-1 exerts direct anabolic effects through satellite cell activation and protein synthesis pathways.​

Study of Craniofacial Changes Among Children and Adolescents Submitted to Growth Hormone Therapy: A Systematic Review: https://pmc.ncbi.nlm.nih.gov/articles/PMC12418064/​

Regarding the maxillary and cranial base differences, one study investigated and observed that maxillary height was 2 mm higher when compared to an untreated control group, whereas one study observed an increase of 1 mm in the posterior cranial base after GH therapy.​

Conclusion:

Puberty is a limited time window, you only go through it once. Ensuring a mix of androgens like Test/DHT and growth factors like HGH all while maintaining good habits and diet will maximise your potential height and dimorphism obtained through puberty.

​

 

[thurzdx]

That sounds good. I saved it to read later

 

[Martes foina]

Shouldve seen this this 6years ago

 

[KittyBreath]

i swear this type of guide has been created more times i can count

 

[Jimcel]

i swear this type of guide has been created more times i can count

I post my guides everywhere, this was for newer forums

I have guides on more niche topics soon

 

[genio]

decent but some outdated information
Like hgh <0.7mg/kg will stunt FAH

 

[genio]

And cjc nd + ghrp2 is the new ghs combo

 

[genio]

Tren does reach AR saturation under <50mg but a bit higher doses will not be a looksmin
Overall decent though

 

[the lavo]

An Introduction to Androgens/Growth factors - The Ultimate Guide to PUBERTYMAXXING **WITH STUDIES**


Preface:

This thread is made under the presumption you are still undergoing puberty which usually ranges from ages 11-17 but can start earlier/end later depending on genetics. You can check if you are still in puberty by getting an X-ray scan on your left hand/wrist to see if growth plates are still open.

Introduction:

I will be explaining growth-inducing lifestyle habits (diet and sleep) and how to utilise Growth factors/ androgens to get the most facial development, increased sexual dimorphism and vertical growth out of puberty.

Lifestyle habits:

Habits during adolescence are underrated when it comes to development. Although they may not be as effective as other methods mentioned, it is
still necessary.

The ideal habits include:

8 Hours + sleep
Adequate hydration (<3L water)
Daily exercise (gym or martial art + some cardio)
Maintain proper posture

Diet:

The optimal diet won’t yield crazy results but is a staple to your protocol as a whole

The optimal diet consists of:

Wholefoods only - greater nutrient density to support hormonal function + skeletal development
300-500 calorie surplus - high energy availability for thyroid function and growth
Protein 1.2-2.2 g/kg bodyweight - supplements muscle/bone growth
Carbohydrates 3-6k/kg/day - provides energy for growth, performance and maintain glycogen stores
Red meat 3-7 times per week - most nutrient dense food for male development
Dairy - Increases IGF-1 and supports bone mineralization
Vitamin D - allows efficient calcium absorption
Healthy fats - supports hormone production (NOT NECESSARY ON AAS)
Zinc -Supports hormone function

Make a diet following these principles - use ChatGPT for this if you are struggling

Testosterone:

Disclaimer: if not managed properly, this can accelerate the fusion of growth plates

Testosterone is the primary androgen driving male puberty. It fuels muscle growth, bone density and width, voice deepening, facial masculinization, body hair, libido, and overall sexual dimorphism. Levels rise sharply from Tanner 2 onward and peak in late puberty.

The best way to increase test is to pick up the needle: Test E 350mg/week

Side effects:

Bloating
Gyno
Higher libido
Increased aggression
Hair loss
Increased blood pressure

Note: These sides are less likely on a dose of 350mg

I will make a thread simplifying every from sourcing to injecting and managing sides soon, but do you own research before proceeding.

Study on effect of low dose test on boys with delayed puberty https://www.researchgate.net/publication/12970434_Effect_of_low-dose_testosterone_treatment_on_craniofacial_growth_in_boys_with_delayed_puberty



Trenbolone:

Disclaimer: if not managed properly, this can accelerate the fusion of growth plates and can negatively impact your health.

Trenbolone is a highly potent synthetic anabolic-androgenic steroid (AAS) originally developed for veterinary use. It is not approved for medical use in humans. It binds strongly to the androgen receptor and has powerful anabolic and androgenic effects.

I would strongly advise staying on low dose as anything more is a looksmin in my opinion:: Trenbolone Acetate 25mg.

Side effects:

Night sweats
Insomnia
Increased heart rate
Appetite suppression
Cough (AKA tren cough)
Increased prolactin
Kidney stress
Tren rage

Note: only use this compound towards the very end or a little bit after puberty.

As previously mentioned, A thread on this is due but also do your own research on these compounds.

Study on impact of trenbolone: https://journals.viamedica.pl/endokrynologia_polska/article/view/99130​

Skeletal muscle hypertrophy. AR—androgen receptor; ARE—androgen response element; β-c—β-catenin; FGF—fibroblast growth factor; GPCR—G protein-related receptor; GSK-1—glycogen synthase kinase 1; IGF-1—insulin-like growth factor 1; MC—myosatellite cell; NICD—Notch intracellular domain; Notch—Notch signalling pathway; Tcf2/Lef—transcriptional repressors/activators; Wnt—Wnt signalling pathway.

Dihydrotestosterone (DHT):

Dihydrotestosterone (DHT) is a potent androgen produced from testosterone by the enzyme 5α-reductase in specific tissues (skin, hair follicles, prostate, genitals). It binds the androgen receptor more strongly than testosterone and does not aromatize into estrogen. It plays a smaller role in muscle growth compared to testosterone but is highly important for sexual dimorphism in hair and genital tissues.

Effective ways to increase DHT (listed from most direct to least):

Direct DHT or strong DHT-derivatives (e.g. topical DHT, Masteron/drostanolone, Proviron/mesterolone)
Higher testosterone base (more substrate for conversion via 5α-reductase)
Supporting 5α-reductase activity: adequate zinc, boron, and overall androgen status

Side effects:

Accelerated male-pattern hair loss (if genetically prone)
Increased body/facial hair
Acne / oily skin
Prostate stimulation (possible enlargement or higher PSA in susceptible individuals)
Potential negative impact on cholesterol with stronger DHT compounds
Suppression of natural hormone production when using exogenous DHT derivatives

Study of Dihydrotestosterone induces a sexual dimorphism in oestrogen uptake by specific anterior pituitary cell types in vivo: https://pubmed.ncbi.nlm.nih.gov/3621311/


HGH/IGF-1:

Human Growth Hormone (HGH) or somatotropin, is a peptide hormone produced by the anterior pituitary gland. It plays a crucial role in growth, tissue repair, metabolism, and body composition by directly affecting tissues and stimulating the production of insulin-like growth factor-1 (IGF-1), primarily in the liver. Insulin-Like Growth Factor 1 is an anabolic peptide hormone acts as the primary downstream mediator of many of HGH's growth-promoting effects and is also essential for normal skeletal growth, tissue repair, and muscle development.

Effective ways to increase HGH/IGF-1 (listed from most effective to least effective)

HGH - 6-8 IUs ED
GHRP2/6 - 100mcg each 3x a day
IGFLR3 40-50mcg twice a day
Mk677 (cheapest + oral) - 15mg ED

Side effects:

Water retention
Insulin retention
Carpal tunnel symptoms
acceleration of moles
Joint pain

Note: some of these sides are only common with HGH, the other options are less risky.

Study of regulation of muscle mass by growth hormone and IGF-1: https://pmc.ncbi.nlm.nih.gov/articles/PMC2439518/?utm_source


Study of Craniofacial Changes Among Children and Adolescents Submitted to Growth Hormone Therapy: A Systematic Review: https://pmc.ncbi.nlm.nih.gov/articles/PMC12418064/


Conclusion:

Puberty is a limited time window, you only go through it once. Ensuring a mix of androgens like Test/DHT and growth factors like HGH all while maintaining good habits and diet will maximise your potential height and dimorphism obtained through puberty.

​

DNR

 

[Jimcel]

decent but some outdated information
Like hgh <0.7mg/kg will stunt FAH

Interesting

And cjc nd + ghrp2 is the new ghs combo

Slightly stronger because 2 different pathways yeah

This guide was low effort because its such a common topic i have more detailed guides on much more niche topics coming soon

Tren does reach AR saturation under <50mg but a bit higher doses will not be a looksmin
Overall decent though

I found that low doses already occupy a high percentage of androgen receptors.

Also, adding higher dosages just adds more risk and often makes people look worse imo

 

[genio]

Oh btw @Jimcel
Testosterone is a dumb androgen to pin for puberty lmao
Dht derivs or tren with low to no test base mog
If you only have access to test it should be ~250mg used with high dose ai and some tamoxifen

 

[Jimcel]

DNR

Unlucky, this guide is for subhuman faggots like yourself

 

[genio]

I found that low doses already occupy a high percentage of androgen receptors.

Yeah that’s what I said

Also, adding higher dosages just adds more risk and often makes people look worse imo

Of course it’s more risky but tren also targets other pathways such as igf-1, etc. I’m sure you know even after ar saturation is reached so it’s not really a looksmin imo even if sides are more common

 

[the lavo]

Unlucky, this guide is for subhuman faggots like yourself

boohoo lil n***a this aint gonna fix genetics your still gonna be in mtn hell

 

[Jimcel]

Oh btw @Jimcel
Testosterone is a dumb androgen to pin for puberty lmao
Dht derivs or tren with low to no test base mog
If you only have access to test it should be ~250mg used with high dose ai and some tamoxifen

I get what your saying, personally ais aren't so necessary on trt doses

At most, maybe low dose

 

[genio]

I get what your saying, personally ais aren't so necessary on trt doses

At most, maybe low dose

250mg isn’t trt
Well honestly you should be nuking e2 either way so high dose ais are necessary for a good pubertymaxxing stack

 

[Jimcel]

boohoo lil n***a this aint gonna fix genetics your still gonna be in mtn hell

Who claimed this would fic genetics?

n***a you are clueless

 

[genio]

boohoo lil n***a this aint gonna fix genetics your still gonna be in mtn hell

Mtn = above average btw

 

[Jimcel]

250mg isn’t trt
Well honestly you should be nuking e2 either way so high dose ais are necessary for a good pubertymaxxing stack

Actually you're right

 

[genio]

Tbh bro u reminded me that tren’s threshold for ar saturation is super low i might js run like 40mg for a longer while after like 6 weeks on my 140mg

 

[genio]

Yeah that’s what I said

Of course it’s more risky but tren also targets other pathways such as igf-1, etc. I’m sure you know even after ar saturation is reached so it’s not really a looksmin imo even if sides are more common

I think u missed this btw

 

[Jimcel]

I think u missed this btw

Yeah i did, was low effort thread as there are so many on this topic

With more niche topics i will go into more detail

 

[genio]

Yeah i did, was low effort thread as there are so many on this topic

With more niche topics i will go into more detail

1.2g test and 800mg tren = holy height