Bed rotting actually decreases bone mass

[PingPong]

Your bones have cells called osteocytes which sense mechanical stimuli, when they sense a lot of stimuli they secrete WNT/b-catenin, PGE2 & nitric oxide which ALL boost bone growth locally.

When you arent active, these same osteocytes secrete sclerostin, which inhibits wnt/b-catenin. The sensor responsible for communicating mechanical stimuli to these osteocyte cells is called integrin alpha 5 and an interesting study was done on this receptor.

Mice who got their integrin alpha 5 deactivated got less bone growth from mechanical loading compared to mice who still had this receptor. If you dont move a lot during puberty especially, you are essentially recreating this; no mechanical loading -> iAlpha5 doesnt get activated -> osteocytes secrete sclerostin -> wnt/b-catenin gets inhibited -> less growth

Goes to show how important it is to be active, get sunlight, go swim, play sports.

I made this myself btw

 

[Thebird]

Lombok

 

[𐲀 𐲢 𐲠 𐲀 𐲇 𐲰]

fuck i thought doing nothing with my life and ldaring would ascend me to chad

 

[Blackpillirony]

Your bones have cells called osteocytes which sense mechanical stimuli, when they sense a lot of stimuli they secrete WNT/b-catenin, PGE2 & nitric oxide which ALL boost bone growth locally.

When you arent active, these same osteocytes secrete sclerostin, which inhibits wnt/b-catenin. The sensor responsible for communicating mechanical stimuli to these osteocyte cells is called integrin alpha 5 and an interesting study was done on this receptor.

Mice who got their integrin alpha 5 deactivated got less bone growth from mechanical loading compared to mice who still had this receptor. If you dont move a lot during puberty especially, you are essentially recreating this; no mechanical loading -> iAlpha5 doesnt get activated -> osteocytes secrete sclerostin -> wnt/b-catenin gets inhibited -> less growth

Goes to show how important it is to be active, get sunlight, go swim, play sports.

I made this myself btw

Ok but what if I bedrot while eating tons of sugar and bonesmash?

 

[PingPong]

Lombok

yeaP

 

[SILVER]

then why am I so chad

 

[PingPong]

Ok but what if I bedrot while eating tons of sugar and bonesmash?

You should add a nail to your regimen for better results

 

[Blackpillirony]

You should add a nail to your regimen for better results

What the fuck is that ?

 

[PingPong]

What the fuck is that ?

 

[ChangNProgress]

Your bones have cells called osteocytes which sense mechanical stimuli, when they sense a lot of stimuli they secrete WNT/b-catenin, PGE2 & nitric oxide which ALL boost bone growth locally.

When you arent active, these same osteocytes secrete sclerostin, which inhibits wnt/b-catenin. The sensor responsible for communicating mechanical stimuli to these osteocyte cells is called integrin alpha 5 and an interesting study was done on this receptor.

Mice who got their integrin alpha 5 deactivated got less bone growth from mechanical loading compared to mice who still had this receptor. If you dont move a lot during puberty especially, you are essentially recreating this; no mechanical loading -> iAlpha5 doesnt get activated -> osteocytes secrete sclerostin -> wnt/b-catenin gets inhibited -> less growth

Goes to show how important it is to be active, get sunlight, go swim, play sports.

I made this myself btw

jew prevents me from being a couch potato with big words

 

[Nocturne]

bedrotting is meta

 

[giga.mia]

Being an iPad kid has done irreparable damage to myself