Guide Dasatinib + Quercetin and Height Growth

[zaycism]

introduction
This guide covers the dasatinib + quercetin (D+Q) height growth hypothesis. Including the biological rationale, how it might affect growth plates, and the evidence that’s currently available. Focusing on the role of cellular senescence in skeletal development.

what are dasatinib and quercetin?

Dasatinib is an anticancer drug, a second-generation tyrosine kinase inhibitor (TKI).
It potently inhibits BCR-ABL and SRC family kinases (non-receptor tyrosine kinases that interact to drive cell proliferation and survival)

Quercetin is a plant compound called a flavonoid. It inhibits phosphoinositide 3-kinase (PI3K) by antioxidant quercetin in ascite cells of Dalton’s lymphoma (DL) mice and down regulates the anti-poptoic proteins of Bcl-XL and Bcl-2

Senescence-Associated Secretory phenotype

Senescent cells accumulate in the body over time and release inflammatory molecules known as the senescence-associated secretory phenotype (SASP) that drive age-related diseases. Dasatinib and quercetin (D+Q) work together as senolytics because they target different survival pathways within these cells. Dasatinib promotes the death of senescent cells by inhibiting Src tyrosine kinase signaling, while quercetin targets anti-apoptotic
pathways such as BCL-xL. When chondrocytes become senescent, they begin producing SASP factors, including cytokines, chemokines, proteases, and growth factors. these molecules can induce a range of physiological responses in the surrounding microenvironment, including inflammation, growth arrest and tumorigenesis. Some early SASP factors, such as Transforming Growth Factor Beta (TGF-β), can even cause nearby healthy cells to become senescent, allowing senescence to spread. Stimulation with D+Q selectively eliminated senescent cells in both, cartilage explants and isolated human articular chondrocytes (HAC). While also increasing COL2A1, ACAN, and SOX9 expression.
results from studies

​

on rats, dasatinib inhibited chondrocyte proliferation which decreased growth plate thickness. This was a 4-12 weeks of usage proving that dasatinib has effects on the growth plates.

usage
if you plan on taking D+Q, i recommend using it for 2 days at the start of your cycle and drop it for 6 weeks, then u repeat the cycle again. you may face side effects like nausea and low energy.​

 

[True Spaniard]

introduction
This guide covers the dasatinib + quercetin (D+Q) height growth hypothesis. Including the biological rationale, how it might affect growth plates, and the evidence that’s currently available. Focusing on the role of cellular senescence in skeletal development.

what are dasatinib and quercetin?
View attachment 365362
Dasatinib is an anticancer drug, a second-generation tyrosine kinase inhibitor (TKI).
It potently inhibits BCR-ABL and SRC family kinases (non-receptor tyrosine kinases that interact to drive cell proliferation and survival)
View attachment 365407

Quercetin is a plant compound called a flavonoid. It inhibits phosphoinositide 3-kinase (PI3K) by antioxidant quercetin in ascite cells of Dalton’s lymphoma (DL) mice and down regulates the anti-poptoic proteins of Bcl-XL and Bcl-2

Senescence-Associated Secretory phenotype

Senescent cells accumulate in the body over time and release inflammatory molecules known as the senescence-associated secretory phenotype (SASP) that drive age-related diseases. Dasatinib and quercetin (D+Q) work together as senolytics because they target different survival pathways within these cells. Dasatinib promotes the death of senescent cells by inhibiting Src tyrosine kinase signaling, while quercetin targets anti-apoptotic
pathways such as BCL-xL. When chondrocytes become senescent, they begin producing SASP factors, including cytokines, chemokines, proteases, and growth factors. these molecules can induce a range of physiological responses in the surrounding microenvironment, including inflammation, growth arrest and tumorigenesis. Some early SASP factors, such as Transforming Growth Factor Beta (TGF-β), can even cause nearby healthy cells to become senescent, allowing senescence to spread. Stimulation with D+Q selectively eliminated senescent cells in both, cartilage explants and isolated human articular chondrocytes (HAC). While also increasing COL2A1, ACAN, and SOX9 expression.
results from studies
View attachment 365391​

on rats, dasatinib inhibited chondrocyte proliferation which decreased growth plate thickness. This was a 4-12 weeks of usage proving that dasatinib has effects on the growth plates.

usage
if you plan on taking D+Q, i recommend using it for 2 days at the start of your cycle and drop it for 6 weeks, then u repeat the cycle again. you may face side effects like nausea and low energy.​

Did read+ mirin effort

 

[zaycism]

[how tf do i masstag

 

[foidslayer]

[how tf do i masstag

add a ] on the spoiler at the start

 

[derpy]

High effort guide, mirin!

 

[zaycism]

add a ] on the spoiler at the start

I dojt understand

 

[foidslayer]

I dojt understand

it should be [SPOILER="" ] without the space

 

[zaycism]

Spoiler: mass tag

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[Dandelions]

Mirin thread bhai!

 

[Superior]

introduction
This guide covers the dasatinib + quercetin (D+Q) height growth hypothesis. Including the biological rationale, how it might affect growth plates, and the evidence that’s currently available. Focusing on the role of cellular senescence in skeletal development.

what are dasatinib and quercetin?
View attachment 365362
Dasatinib is an anticancer drug, a second-generation tyrosine kinase inhibitor (TKI).
It potently inhibits BCR-ABL and SRC family kinases (non-receptor tyrosine kinases that interact to drive cell proliferation and survival)
View attachment 365407

Quercetin is a plant compound called a flavonoid. It inhibits phosphoinositide 3-kinase (PI3K) by antioxidant quercetin in ascite cells of Dalton’s lymphoma (DL) mice and down regulates the anti-poptoic proteins of Bcl-XL and Bcl-2

Senescence-Associated Secretory phenotype

Senescent cells accumulate in the body over time and release inflammatory molecules known as the senescence-associated secretory phenotype (SASP) that drive age-related diseases. Dasatinib and quercetin (D+Q) work together as senolytics because they target different survival pathways within these cells. Dasatinib promotes the death of senescent cells by inhibiting Src tyrosine kinase signaling, while quercetin targets anti-apoptotic
pathways such as BCL-xL. When chondrocytes become senescent, they begin producing SASP factors, including cytokines, chemokines, proteases, and growth factors. these molecules can induce a range of physiological responses in the surrounding microenvironment, including inflammation, growth arrest and tumorigenesis. Some early SASP factors, such as Transforming Growth Factor Beta (TGF-β), can even cause nearby healthy cells to become senescent, allowing senescence to spread. Stimulation with D+Q selectively eliminated senescent cells in both, cartilage explants and isolated human articular chondrocytes (HAC). While also increasing COL2A1, ACAN, and SOX9 expression.
results from studies
View attachment 365391​

on rats, dasatinib inhibited chondrocyte proliferation which decreased growth plate thickness. This was a 4-12 weeks of usage proving that dasatinib has effects on the growth plates.

usage
if you plan on taking D+Q, i recommend using it for 2 days at the start of your cycle and drop it for 6 weeks, then u repeat the cycle again. you may face side effects like nausea and low energy.​

I didn't understand a thing but nice

 

[zaycism]

I didn't understand a thing but nice

TLDR: dasatinib and quercetin can make u taller

 

[Superior]

TLDR: dasatinib and quercetin can make u taller

but im 18 and 5'3

 

[zaycism]

but im 18 and 5'3

Reincarnation

 

[HerculesJr.]

introduction
This guide covers the dasatinib + quercetin (D+Q) height growth hypothesis. Including the biological rationale, how it might affect growth plates, and the evidence that’s currently available. Focusing on the role of cellular senescence in skeletal development.

what are dasatinib and quercetin?
View attachment 365362
Dasatinib is an anticancer drug, a second-generation tyrosine kinase inhibitor (TKI).
It potently inhibits BCR-ABL and SRC family kinases (non-receptor tyrosine kinases that interact to drive cell proliferation and survival)
View attachment 365407

Quercetin is a plant compound called a flavonoid. It inhibits phosphoinositide 3-kinase (PI3K) by antioxidant quercetin in ascite cells of Dalton’s lymphoma (DL) mice and down regulates the anti-poptoic proteins of Bcl-XL and Bcl-2

Senescence-Associated Secretory phenotype

Senescent cells accumulate in the body over time and release inflammatory molecules known as the senescence-associated secretory phenotype (SASP) that drive age-related diseases. Dasatinib and quercetin (D+Q) work together as senolytics because they target different survival pathways within these cells. Dasatinib promotes the death of senescent cells by inhibiting Src tyrosine kinase signaling, while quercetin targets anti-apoptotic
pathways such as BCL-xL. When chondrocytes become senescent, they begin producing SASP factors, including cytokines, chemokines, proteases, and growth factors. these molecules can induce a range of physiological responses in the surrounding microenvironment, including inflammation, growth arrest and tumorigenesis. Some early SASP factors, such as Transforming Growth Factor Beta (TGF-β), can even cause nearby healthy cells to become senescent, allowing senescence to spread. Stimulation with D+Q selectively eliminated senescent cells in both, cartilage explants and isolated human articular chondrocytes (HAC). While also increasing COL2A1, ACAN, and SOX9 expression.
results from studies
View attachment 365391​

on rats, dasatinib inhibited chondrocyte proliferation which decreased growth plate thickness. This was a 4-12 weeks of usage proving that dasatinib has effects on the growth plates.

usage
if you plan on taking D+Q, i recommend using it for 2 days at the start of your cycle and drop it for 6 weeks, then u repeat the cycle again. you may face side effects like nausea and low energy.​

hello MY NAME is zaycism and i enjoy coating my food in my friends vaginal juices

 

[zaycism]

@iwannadowhatspringdoes

 

[genio]

I didn't understand a thing but nice

Senescent cells = make u shorter
D + Q = kill senescent cells and increases growth factors
D + Q = make you taller

 

[genio]

introduction
This guide covers the dasatinib + quercetin (D+Q) height growth hypothesis. Including the biological rationale, how it might affect growth plates, and the evidence that’s currently available. Focusing on the role of cellular senescence in skeletal development.

what are dasatinib and quercetin?
View attachment 365362
Dasatinib is an anticancer drug, a second-generation tyrosine kinase inhibitor (TKI).
It potently inhibits BCR-ABL and SRC family kinases (non-receptor tyrosine kinases that interact to drive cell proliferation and survival)
View attachment 365407

Quercetin is a plant compound called a flavonoid. It inhibits phosphoinositide 3-kinase (PI3K) by antioxidant quercetin in ascite cells of Dalton’s lymphoma (DL) mice and down regulates the anti-poptoic proteins of Bcl-XL and Bcl-2

Senescence-Associated Secretory phenotype

Senescent cells accumulate in the body over time and release inflammatory molecules known as the senescence-associated secretory phenotype (SASP) that drive age-related diseases. Dasatinib and quercetin (D+Q) work together as senolytics because they target different survival pathways within these cells. Dasatinib promotes the death of senescent cells by inhibiting Src tyrosine kinase signaling, while quercetin targets anti-apoptotic
pathways such as BCL-xL. When chondrocytes become senescent, they begin producing SASP factors, including cytokines, chemokines, proteases, and growth factors. these molecules can induce a range of physiological responses in the surrounding microenvironment, including inflammation, growth arrest and tumorigenesis. Some early SASP factors, such as Transforming Growth Factor Beta (TGF-β), can even cause nearby healthy cells to become senescent, allowing senescence to spread. Stimulation with D+Q selectively eliminated senescent cells in both, cartilage explants and isolated human articular chondrocytes (HAC). While also increasing COL2A1, ACAN, and SOX9 expression.
results from studies
View attachment 365391​

on rats, dasatinib inhibited chondrocyte proliferation which decreased growth plate thickness. This was a 4-12 weeks of usage proving that dasatinib has effects on the growth plates.

usage
if you plan on taking D+Q, i recommend using it for 2 days at the start of your cycle and drop it for 6 weeks, then u repeat the cycle again. you may face side effects like nausea and low energy.​

How much did rhe rats grow

 

[foidslayer]

introduction
This guide covers the dasatinib + quercetin (D+Q) height growth hypothesis. Including the biological rationale, how it might affect growth plates, and the evidence that’s currently available. Focusing on the role of cellular senescence in skeletal development.

what are dasatinib and quercetin?
View attachment 365362
Dasatinib is an anticancer drug, a second-generation tyrosine kinase inhibitor (TKI).
It potently inhibits BCR-ABL and SRC family kinases (non-receptor tyrosine kinases that interact to drive cell proliferation and survival)
View attachment 365407

Quercetin is a plant compound called a flavonoid. It inhibits phosphoinositide 3-kinase (PI3K) by antioxidant quercetin in ascite cells of Dalton’s lymphoma (DL) mice and down regulates the anti-poptoic proteins of Bcl-XL and Bcl-2

Senescence-Associated Secretory phenotype

Senescent cells accumulate in the body over time and release inflammatory molecules known as the senescence-associated secretory phenotype (SASP) that drive age-related diseases. Dasatinib and quercetin (D+Q) work together as senolytics because they target different survival pathways within these cells. Dasatinib promotes the death of senescent cells by inhibiting Src tyrosine kinase signaling, while quercetin targets anti-apoptotic
pathways such as BCL-xL. When chondrocytes become senescent, they begin producing SASP factors, including cytokines, chemokines, proteases, and growth factors. these molecules can induce a range of physiological responses in the surrounding microenvironment, including inflammation, growth arrest and tumorigenesis. Some early SASP factors, such as Transforming Growth Factor Beta (TGF-β), can even cause nearby healthy cells to become senescent, allowing senescence to spread. Stimulation with D+Q selectively eliminated senescent cells in both, cartilage explants and isolated human articular chondrocytes (HAC). While also increasing COL2A1, ACAN, and SOX9 expression.
results from studies
View attachment 365391​

on rats, dasatinib inhibited chondrocyte proliferation which decreased growth plate thickness. This was a 4-12 weeks of usage proving that dasatinib has effects on the growth plates.

usage
if you plan on taking D+Q, i recommend using it for 2 days at the start of your cycle and drop it for 6 weeks, then u repeat the cycle again. you may face side effects like nausea and low energy.​

Any results on humans?

Humans and rats can react differently to it

 

[zaycism]

How much did rhe rats grow

the studies didnt report their height, what was measured was the growth palate structure, (COL2A1, ACAN, SOX9), and cartilagae quality also the senescent cell markers

 

[zaycism]

Any results on humans?

Humans and rats can react differently to it

there are case reports

 

[iwannadowhatspringdoes]

bump

 

[genio]

Humans and rats can react differently to it

NAH REALLY n***a

 

[genio]

the studies didnt report their height, what was measured was the growth palate structure, (COL2A1, ACAN, SOX9), and cartilagae quality also the senescent cell markers

Cool beans

there are case reports

what happened

 

[zaycism]

Cool beans

what happened

since these reports were done on adults, and their growth plates were closed there was no reported height growth it reduced markers on cellular senescence and there were improvements in phsycil function measures

 

[giga.mia]

introduction
This guide covers the dasatinib + quercetin (D+Q) height growth hypothesis. Including the biological rationale, how it might affect growth plates, and the evidence that’s currently available. Focusing on the role of cellular senescence in skeletal development.

what are dasatinib and quercetin?
View attachment 365362
Dasatinib is an anticancer drug, a second-generation tyrosine kinase inhibitor (TKI).
It potently inhibits BCR-ABL and SRC family kinases (non-receptor tyrosine kinases that interact to drive cell proliferation and survival)
View attachment 365407

Quercetin is a plant compound called a flavonoid. It inhibits phosphoinositide 3-kinase (PI3K) by antioxidant quercetin in ascite cells of Dalton’s lymphoma (DL) mice and down regulates the anti-poptoic proteins of Bcl-XL and Bcl-2

Senescence-Associated Secretory phenotype

Senescent cells accumulate in the body over time and release inflammatory molecules known as the senescence-associated secretory phenotype (SASP) that drive age-related diseases. Dasatinib and quercetin (D+Q) work together as senolytics because they target different survival pathways within these cells. Dasatinib promotes the death of senescent cells by inhibiting Src tyrosine kinase signaling, while quercetin targets anti-apoptotic
pathways such as BCL-xL. When chondrocytes become senescent, they begin producing SASP factors, including cytokines, chemokines, proteases, and growth factors. these molecules can induce a range of physiological responses in the surrounding microenvironment, including inflammation, growth arrest and tumorigenesis. Some early SASP factors, such as Transforming Growth Factor Beta (TGF-β), can even cause nearby healthy cells to become senescent, allowing senescence to spread. Stimulation with D+Q selectively eliminated senescent cells in both, cartilage explants and isolated human articular chondrocytes (HAC). While also increasing COL2A1, ACAN, and SOX9 expression.
results from studies
View attachment 365391​

on rats, dasatinib inhibited chondrocyte proliferation which decreased growth plate thickness. This was a 4-12 weeks of usage proving that dasatinib has effects on the growth plates.

Pls correct me if I’m retarded but if it deceased growth plate thickness isn’t that a negative impact on height? And the study is referring to mice that were put under radiation to damage their tissues and used the d+q as a treatment for their function, it doesn’t say anything about healthy legs vs add on d+q. The benefit also doesn’t appear that potent here and it’s not showing us anything ab height growth
Also Are there any studies on its impact on human height growth instead of mice

 

[zaycism]

Pls correct me if I’m retarded but if it deceased growth plate thickness isn’t that a negative impact on height?

this may sound bad this was after a prolonged usage of 4-12 weeks and proves that dasa has effects on the growth plates

And the study is referring to mice that were put under radiation to damage their tissues and used the d+q as a treatment for their function, it doesn’t say anything about healthy legs vs add on d+q. The benefit also doesn’t appear that potent here and it’s not showing us anything ab height growth

Yes rhe study is about radiation and injuries its showing that removing senescent cells can improve tissue and regenerative capacity in damaged or aged tissue models
its not proving height growth directly its testing whether sen cells improve SASP and progenitor function thats upstream of growth process

Also Are there any studies on its impact on human height growth instead of mice

no there are cases on adults whose growth plates are closed, only observations of reduced markers of cellular senescence; chnages in inflammatory; improvements in physical function

 

[genio]

since these reports were done on adults, and their growth plates were closed there was no reported height growth it reduced markers on cellular senescence and there were improvements in phsycil function measures

Son u can be the next case report

 

[giga.mia]

this may sound bad this was after a prolonged usage of 4-12 weeks and proves that dasa has effects on the growth plates

Yes but the effect in this situation would be decreased growth plate thickness which..doesnt that negatively impact height growth?

Yes rhe study is about radiation and injuries its showing that removing senescent cells can improve tissue and regenerative capacity in damaged or aged tissue models
its not proving height growth directly its testing whether sen cells improve SASP and progenitor function thats upstream of growth process

no there are cases on adults whose growth plates are closed, only observations of reduced markers of cellular senescence; chnages in inflammatory; improvements in physical function

So then do we still think ts is worth it? It feels like cope
I understand your hypothesis tho

 

[James]

Yes but the effect in this situation would be decreased growth plate thickness which..doesnt that negatively impact height growth?

So then do we still think ts is worth it? It feels like cope
I understand your hypothesis tho

its not good, dasa is shit, overall very net-negative MOAS.

 

[zaycism]

Yes but the effect in this situation would be decreased growth plate thickness which..doesnt that negatively impact height growth?

So then do we still think ts is worth it? It feels like cope
I understand your hypothesis tho

decrease growth playe thickness doesnt automatically mean worse height outcome it depends on proliferation organization and signaling balance. and those studies are in damaged radiation models anyway, so you can’t directly map it to normal growth or height outcomes. at best the data shows changes in senescence markers

 

[rand anon]

Mirin guide, this unc’s growth plates hve been closed for nearly a decade now unfortunately

 

[tami_26]

introduction
This guide covers the dasatinib + quercetin (D+Q) height growth hypothesis. Including the biological rationale, how it might affect growth plates, and the evidence that’s currently available. Focusing on the role of cellular senescence in skeletal development.

what are dasatinib and quercetin?
View attachment 365362
Dasatinib is an anticancer drug, a second-generation tyrosine kinase inhibitor (TKI).
It potently inhibits BCR-ABL and SRC family kinases (non-receptor tyrosine kinases that interact to drive cell proliferation and survival)
View attachment 365407

Quercetin is a plant compound called a flavonoid. It inhibits phosphoinositide 3-kinase (PI3K) by antioxidant quercetin in ascite cells of Dalton’s lymphoma (DL) mice and down regulates the anti-poptoic proteins of Bcl-XL and Bcl-2

Senescence-Associated Secretory phenotype

Senescent cells accumulate in the body over time and release inflammatory molecules known as the senescence-associated secretory phenotype (SASP) that drive age-related diseases. Dasatinib and quercetin (D+Q) work together as senolytics because they target different survival pathways within these cells. Dasatinib promotes the death of senescent cells by inhibiting Src tyrosine kinase signaling, while quercetin targets anti-apoptotic
pathways such as BCL-xL. When chondrocytes become senescent, they begin producing SASP factors, including cytokines, chemokines, proteases, and growth factors. these molecules can induce a range of physiological responses in the surrounding microenvironment, including inflammation, growth arrest and tumorigenesis. Some early SASP factors, such as Transforming Growth Factor Beta (TGF-β), can even cause nearby healthy cells to become senescent, allowing senescence to spread. Stimulation with D+Q selectively eliminated senescent cells in both, cartilage explants and isolated human articular chondrocytes (HAC). While also increasing COL2A1, ACAN, and SOX9 expression.
results from studies
View attachment 365391​

on rats, dasatinib inhibited chondrocyte proliferation which decreased growth plate thickness. This was a 4-12 weeks of usage proving that dasatinib has effects on the growth plates.

usage
if you plan on taking D+Q, i recommend using it for 2 days at the start of your cycle and drop it for 6 weeks, then u repeat the cycle again. you may face side effects like nausea and low energy.​

Seeing a whole load of Benzenes and phenols

 

[germanicccccccc]

Mirin