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Heres a few quotes
They are about androgens
They are about androgens
“Even though AR is expressed in chondrocytes, experiments show that AR activation alone doesn’t significantly drive longitudinal bone growth or growth plate closure
ERa is the main receptor responsible for growth plate closure
Androgens can actually have positive effects on growth by affecting IGF-1 and GH pathways
This is why non-aromatizing androgens would increase growth not stunt it“
“Why do adolescents treated with DHT and it's derivatives find increases in height and lean body mass? Puberty still results in increased type 1 5AR enzymes which can still make some DHT. It may not be necessary as a main driver of bone growth during puberty but it still has positive effects on periosteal bone formation”
“Sorry wait i forgot to add something
It isnt negligible at all
Circulating serum DHT does not equivocate local DHT production within bone tissue 5ARD is a deficiency of the type 2 5AR yes? Type 1 5AR is the receptor type that is clearly expressed in osteoblasts whilst type 2 is not found or undetectable in bone tissue Bone can still make and use androgens locally and bone still expresses type 1 5AR”
ERa is the main receptor responsible for growth plate closure
Androgens can actually have positive effects on growth by affecting IGF-1 and GH pathways
This is why non-aromatizing androgens would increase growth not stunt it“
“Why do adolescents treated with DHT and it's derivatives find increases in height and lean body mass? Puberty still results in increased type 1 5AR enzymes which can still make some DHT. It may not be necessary as a main driver of bone growth during puberty but it still has positive effects on periosteal bone formation”
“Sorry wait i forgot to add something
It isnt negligible at all
Circulating serum DHT does not equivocate local DHT production within bone tissue 5ARD is a deficiency of the type 2 5AR yes? Type 1 5AR is the receptor type that is clearly expressed in osteoblasts whilst type 2 is not found or undetectable in bone tissue Bone can still make and use androgens locally and bone still expresses type 1 5AR”
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