I have heard a lot of people recommend hgh dosages of between 6-10ius ed on this forum, but in my opinion, this is probably not worth it. Instead I think megadosing cbtm. Here is why I believe this:
1) The average male in late puberty (e.g 15-17, varies based on individual) produces approximately 1.8mg/day of hgh endogenously( Source ). This translates to roughly 5-6 ius per day. Therefore, since exogenous gh suppresses natural production (source), any dosage under 6ius would likely do nothing at all, or possibly be a net negative.
2) There appears to be a relatively favorable dose response curve up to and above 0.2 iu/kg/day (roughly 14 ius/day for a 150lb person) (source). From what I understand, the risk of acromegaly, carpal tunnel, etc is pretty exaggerated. Especially given the established natural production above it is unlikely that an hgh dose in the same order of magnitude as is produced naturally would have such pronounced side effects. Therefore, I believe dosages of 20-40 ius ed could potentially be worth the risk and cost if you are after a more time efficient cycle.
There are a few uncertainties I have and would appreciate some input on. First, perhaps exogenous gh has different effects on the liver since it is absorbed more slowly, and maybe elevates igf1 for longer, causing more bone growth? That would explain the 6-10iu supposed sweet spot. Also, maybe megadosing causes a higher % of igf1 to bind to the insulin receptor (due to there being more of it), thus causing hypoglycemia and making you diabetic? This is def something to be wary of. Overall I still think taking higher dosage hgh will have more pronounced effects than current protocols though.
1) The average male in late puberty (e.g 15-17, varies based on individual) produces approximately 1.8mg/day of hgh endogenously( Source ). This translates to roughly 5-6 ius per day. Therefore, since exogenous gh suppresses natural production (source), any dosage under 6ius would likely do nothing at all, or possibly be a net negative.
2) There appears to be a relatively favorable dose response curve up to and above 0.2 iu/kg/day (roughly 14 ius/day for a 150lb person) (source). From what I understand, the risk of acromegaly, carpal tunnel, etc is pretty exaggerated. Especially given the established natural production above it is unlikely that an hgh dose in the same order of magnitude as is produced naturally would have such pronounced side effects. Therefore, I believe dosages of 20-40 ius ed could potentially be worth the risk and cost if you are after a more time efficient cycle.
There are a few uncertainties I have and would appreciate some input on. First, perhaps exogenous gh has different effects on the liver since it is absorbed more slowly, and maybe elevates igf1 for longer, causing more bone growth? That would explain the 6-10iu supposed sweet spot. Also, maybe megadosing causes a higher % of igf1 to bind to the insulin receptor (due to there being more of it), thus causing hypoglycemia and making you diabetic? This is def something to be wary of. Overall I still think taking higher dosage hgh will have more pronounced effects than current protocols though.