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Pepitum is an endogenously produced bioactive 14 amino acid peptide which is especially interesting for us in it's pegylated form, it acts directly on osteoblasts through NCAM1 signaling to promote their maturation and formation of new bone, leading to enhanced trabecular bone growth and strength (for lifting)
however, what makes it even more special is that it has another mechanism, Peptium simultaneously activates an inhibtory paracrine loop by stimulating the release of OPG, which functions as a decoy receptor for RANKL, which is one of the major factors for bone breakdown, OPG effectively prevents RANKL from binding to RANK, which results in a significant inhibition of osteoclast activity and bone resorption. Furthermore clinical trials show that it exerts very high selectivity for bone tissue since it's activation requires select conditions that most likely osteoblasts expresses.
such as the correct NCAM isoforms that actually possess an intracellular tail, as well as the correct FGFR complex that allows for preferred activation or ERK, PI3K AKT or receptor receptor cycling over the classical PLCY..
however, what makes it even more special is that it has another mechanism, Peptium simultaneously activates an inhibtory paracrine loop by stimulating the release of OPG, which functions as a decoy receptor for RANKL, which is one of the major factors for bone breakdown, OPG effectively prevents RANKL from binding to RANK, which results in a significant inhibition of osteoclast activity and bone resorption. Furthermore clinical trials show that it exerts very high selectivity for bone tissue since it's activation requires select conditions that most likely osteoblasts expresses.
such as the correct NCAM isoforms that actually possess an intracellular tail, as well as the correct FGFR complex that allows for preferred activation or ERK, PI3K AKT or receptor receptor cycling over the classical PLCY..
