Peptides:
Ive listed 20. if theres more you want to see reply with them and i may or may not add them
What Are Peptides?
Peptides are short amino acid chains and are also fucking goated. if you aren’t on them or going to get on them you’re wasting potential
Popular Peptides
1. GHK-Cu
Purpose: Skin rejuvenation, wound healing, anti-aging
Overview: stimulates collagen, reduces inflammation, and promotes skin repair [1].
Pros:
Increases collagen and elastin, improving skin firmness [1]
Reduces fine lines and acne scars [2]
Anti-inflammatory, helps with redness [1]
May promote hair growth by supporting follicles [3]
Available topically or as injectable
Cons:
Topical forms have limited penetration [2]
Injectable
Possible temporary stinging/redness [2]
Expensive
Limited human triels
Ease of Access: Moderate. Topical serums available online.
Ease of Use: Topical is simple (apply as serum). Injectables less so.
Results: Smoother skin in 1-2 months; injectables may act faster [2].
Source: [1] Pickart et al., J Biomater Sci Polym Ed, 2012; [2] Pickart, Front Chem, 2018; [3] Uno et al., J Invest Dermatol, 2009.
2. Matrixyl 3000 (Palmitoyl Tripeptide-1 + Palmitoyl Tetrapeptide-7)
Purpose: Anti-aging, wrinkle reduction
Overview: A peptide blend that boosts collagen and reduces inflammation [4].
Pros:
Reduces wrinkles by up to 45% in trials [4]
Enhances skin elasticity/texture [4]
Affordable in serums
Non-irritating for most [4]
Complements retinoids/vitamin C
Cons:
Results take 2-3 months [4]
Minimal effect on deep wrinkles
Avoid low-pH products [4]
Ease of Access: High.
Ease of Use: Very easy apply AM/PM. Wait 20-30 minutes with acids.
Results: Reduced fine lines, improved plumpness in 6-8 weeks [4].
Source: [4] Schagen, Dermatoendocrinol, 2017.
3. BPC-157
Purpose: Tissue repair, gut health, recovery
Overview: A synthetic peptide from a stomach protein, promotes recovery and reduces inflammation [5].
Pros:
Accelerates wound and tissue repair [5]
May improve gut health, aiding skin clarity [6]
Anecdotal reports of reduced acne/scarring
Supports muscle/joint recovery [5]
Some neuroprotection evidence [7]
Cons:
Limited human studies; mostly animal data [5]
Side effects: nausea, blood pressure changes if overdosed
Injectable only
Sourcing tricky due to variable purity
Ease of Access: Low. Sold as research chemicals.
Ease of Use: Moderate. Subcutaneous/intramuscular injections.
Results: Faster recovery, improved skin texture in weeks [6].
Source: [5] Sikiric et al., Curr Pharm Des, 2014; [6] Vukojevic et al., J Clin Med, 2020; [7] Gjurasin et al., Eur J Pharmacol, 2010.
4. CJC-1295 + Ipamorelin
Purpose: Muscle growth, fat loss, anti-aging
Overview: Growth hormone secretagogues that stimulate HGH release, aiding muscle, fat loss, and skin elasticity [8].
Pros:
Enhances muscle mass/recovery [8]
Promotes fat loss via metabolism [9]
May improve skin firmness [8]
Improves sleep/energy (anecdotal)
Cons:
Side effects: joint pain, water retention, insulin resistance [8]
Nightly injections needed
Long-term safety understudied
Expensive
May suppress natural HGH if not cycled [9]
Ease of Access: Low. Available via clinics or peptide suppliers w/ prescription .
Ease of Use: Moderate. Subcutaneous injections.
Results: Musclegain/fat loss in 2-3 months with diet/training [8].
Source: [8] Teichman et al., J Clin Endocrinol Metab, 2006; [9] Sigalos et al., Front Endocrinol, 2017.
5. GLP-1 Agonists (e.g., Reta, Semaglutide, Tirzepatide)
Purpose: Fat loss, metabolic health
Overview: Mimic glucagon-like peptide-1 to regulate appetite and blood sugar, effective for weight loss [10].
Pros:
10-20% body weight loss possible [10]
Improves blood sugar/insulin sensitivity [11]
FDA-approved (Ozempic, Mounjaro)
Weekly injections
Cons:
Side effects: nausea, digestive issues, gallbladder problems [10]
Prescription versions costly
Research chemical versions risky
Plateaus without lifestyle changes
Ease of Access: Moderate. Prescription versions need doctor approval; research versions online.
Ease of Use: High. Weekly subcutaneous injections, titrated dosing.
Results: Fat loss in 3-6 months, skin benefits secondary [11].
Source: [10] Wilding et al., N Engl J Med, 2021; [11] Davies et al., Lancet, 2021.
6. Argireline (Acetyl Hexapeptide-8)
Purpose: Wrinkle reduction, Botox alternative
Overview: Inhibits muscle contractions to reduce dynamic wrinkles, especially on forehead/eyes [12].
Pros:
Reduces expression lines topically [12]
Affordable
Safe
Complements Matrixyl
Easy to use
Cons:
Less effective than Botox [12]
Temporary results, daily use needed
Limited penetration
Minimal effect for some
Avoid strong exfoliants
Ease of Access: High.
Ease of Use: Very easy. Apply twice daily.
Results: Subtle wrinkle reduction in 4-6 weeks [12].
Source: [12] Blanes-Mira et al., Int J Cosmet Sci, 2002.
7. Melanotan II
Purpose: Tanning, libido enhancement
Overview: Stimulates melanin for tanning and may boost libido [13].
Pros:
Natural-looking tan with minimal UV [13]
Enhances skin tone
May increase libido
Fast results (1-2 weeks)
Low-dose effectiveness
Cons:
Side effects: nausea, flushing, moles [13]
Risk of uneven tanning
Careful dosing needed
Ease of Access: Moderate. Sold as research chemicals, quality varies.
Ease of Use: Moderate. Subcutaneous injections with loading phase.
Results: Tan in days to weeks, libido boost for some [13].
Source: [13] Dorr et al., Life Sci, 1996.
8. GHRP-6
Purpose: Muscle growth, fat loss, appetite stimulation
Overview: Stimulates HGH, promoting muscle growth and fat loss, with strong appetite increase [14].
Pros:
Boosts muscle mass/recovery [14]
Enhances fat loss
May improve skin via HGH
Useful for bulking
Affordable vs. other GHRPs
Cons:
Intense hunger spikes [14]
Side effects: water retention, fatigue
Multiple daily injections
Less studied than CJC-1295
Sourcing caution needed
Ease of Access: Moderate. Available from peptide suppliers.
Ease of Use: Low. Frequent injections.
Results: Muscle/fat loss in 2-3 months [14].
Source: [14] Frago et al., Endocrinology, 2002.
9. IGF-1 LR3
Purpose: Muscle growth, fat loss, recovery
Overview: Synthetic insulin-like growth factor, promotes muscle hypertrophy and fat metabolism [15].
Pros:
Potent for muscle growth/recovery [15]
Enhances fat loss
May improve skin firmness
Long-acting, fewer injections
Cons:
Side effects: hypoglycemia, joint pain [15]
Risk of organ growth
Injectable only
Expensive
Ease of Access: Low. Sold as research chemicals.
Ease of Use: Moderate. Subcutaneous injections.
Results: Muscle gains in 1-2 months, subtle skin benefits [15].
Source: [15] Adams et al., J Appl Physiol, 2007.
10. Hexarelin
Purpose: Muscle growth, fat loss, skin health
Overview: Growth hormone secretagogue, stimulates HGH for muscle, fat loss, and potential skin benefits [16].
Pros:
Potent HGH stimulator [16]
May improve skin elasticity
Fast-acting
Enhances strength/recovery
Improves sleep (anecdotal)
Cons:
Increases cortisol/prolactin [16]
Hunger or water retention
Multiple daily injections
Understudied long-term
Hard to source
Ease of Access: Low. Available from peptide suppliers.
Ease of Use: Low. Frequent injections.
Results: Muscle/fat loss in 2-3 months [16].
Source: [16] Deghenghi et al., Endocrine, 2001.
11. Thymosin Alpha-1
Purpose: Immune support, skin health
Overview: Boosts immune function and reduces inflammation [17].
Pros:
Enhances immune response, aiding skin infections [17]
Reduces acne/redness
Supports overall health
Studied for cancer/infections
Cons:
Limited direct skin evidence
Injectable only
Expensive
long-term effects
Ease of Access: Low. Sold by specialized suppliers.
Ease of Use: Moderate. Subcutaneous injections.
Results: Subtle skin clarity in 3-6 months [17].
Source: [17] Romani et al., Ann N Y Acad Sci, 2010.
12. Epitalon
Purpose: Anti-aging, stress resistance
Overview: Activates telomerase to slow cellular aging, potentially improving skin/hair [18].
Pros:
May reduce visible aging [18]
Antioxidant properties
Anecdotal hair/skin benefits
Improves stress resilience
Safe in short cycles
Cons:
Limited human studies
Long-term effects speculative
Injectable only
Hard to source
Expensive
Ease of Access: Low. Niche peptide suppliers.
Ease of Use: Moderate. Subcutaneous injections, short cycles.
Results: Subtle anti-aging after 2-3 cycles [18].
Source: [18] Khavinson et al., Neuro Endocrinol Lett, 2003.
13. TB-500 (Thymosin Beta-4)
Purpose: Tissue repair, hair growth, recovery
Overview: Promotes cell migration and tissue repair, used for recovery and potential hair regrowth [19].
Pros:
Accelerates muscle/tendon/skin healing [19]
Anecdotal hair regrowth
Reduces inflammation
Synergizes with BPC-157
Cons:
Limited human hair data
Side effects: fatigue, headaches
Injectable only
Expensive
Ease of Access: Low. Research chemical suppliers.
Ease of Use: Moderate. Subcutaneous/intramuscular injections.
Results: Recovery in weeks; hair growth inconsistent [19].
Source: [19] Philp et al., FASEB J, 2004.
14. Dihexa
Purpose: Cognitive enhancement, skin repair
Overview: Enhances brain function and may promote skin/hair via angiogenesis [20].
Pros:
Stimulates tissue repair/blood vessel growth [20]
Anecdotal hair thickness
May boost mental clarity
Oral/topical forms available
anti-aging interest
Cons:
Limited human studies
Side effects unclear
Low oral bioavailability
Very hard to source
Expensive
Ease of Access: Very low. Select research suppliers.
Ease of Use: Moderate. Topical/oral easier than injectables.
Results: Speculative skin/hair benefits; cognitive effects stronger [20].
Source: [20] McCoy et al., J Med Chem, 2013.
15. Pentapeptide-3 (Vialox)
Purpose: Wrinkle reduction
Overview: Inhibits muscle contractions, similar to Argireline, targeting dynamic wrinkles [21].
Pros:
Reduces fine lines [21]
Non-invasive Botox alternative
Safe for topical use
Complements other peptides
Affordable in some serums
Cons:
Less effective than Botox
Daily use needed
Limited penetration
Less studied than Argireline
Ease of Access: Moderate. Niche serums.
Ease of Use: Very easy. Apply daily.
Results: Subtle wrinkle reduction in 4-6 weeks [21].
Source: [21] Lintner, Int J Cosmet Sci, 2003.
16. Snap-8 (Acetyl Octapeptide-3)
Purpose: Wrinkle reduction
Overview: Advanced Argireline, inhibits muscle contractions for deeper wrinkles [22].
Pros:
More potent than Argireline [22]
Safe for topical use
Enhances smoothness
Works with other peptides
Non-irritating
Cons:
Less effective than Botox
Daily use required
Limited availability
Higher cost
Penetration issues
Ease of Access: Moderate. Premium serums.
Ease of Use: Very easy. Apply daily.
Results: Wrinkle reduction in 6-8 weeks [22].
Source: [22] Gutierrez et al., Cosmet Toiletries, 2009.
17. DSIP (Delta Sleep-Inducing Peptide)
Purpose: Sleep enhancement, stress reduction
Overview: Promotes deep sleep, reducing cortisol [23].
Pros:
Improves sleep, aiding skin repair [23]
May reduce cortisol-related skin issues
Supports recovery
Well-tolerated
Anecdotal mood benefits
Cons:
Limited direct aesthetic benefits
Injectable only
Hard to source
Variable effects
Minimal human studies
Ease of Access: Low. Niche suppliers.
Ease of Use: Moderate. Subcutaneous injections pre-bed.
Results: Better sleep in days, indirect skin benefits [23].
Source: [23] Schioth et al., Peptides, 1998.
18. AOD-9604
Purpose: Fat loss, metabolism
Overview: HGH fragment targeting fat metabolism without muscle or blood sugar effects [24].
Pros:
Promotes fat loss [24]
Minimal side effects vs. HGH
May improve skin via fat reduction
Well-studied for obesity
Simple dosing
Cons:
Limited muscle benefits
Requires diet/exercise
Expensive
Ease of Access: Moderate. Research chemical suppliers.
Ease of Use: Moderate. Daily subcutaneous injections.
Results: Fat loss in 2-3 months [24].
Source: [24] Heffernan et al., J Clin Endocrinol Metab, 2001.
19. PTD-DBM
Purpose: Hair regrowth
Overview: Activates Wnt/β-catenin pathway for hair follicle growth, often with microneedling [25].
Pros:
Enhances hair thickness
Topical application
Synergizes with microneedling
hair restoration interest
Cons:
Limited clinical data
Consistent application needed
Hard to source
Expensive
Microneedling enhances results
Ease of Access: Low. Niche research suppliers.
Ease of Use: Moderate. Topical, often with microneedling.
Results: Hair regrowth in 3-6 months [25].
Source: [25] Ryu et al., J Invest Dermatol, 2019.
20. LL-37
Purpose: Skin health, antimicrobial
Overview: Antimicrobial peptide that fights skin infections and promotes wound healing [26].
Pros:
Reduces acne-causing bacteria [26]
Supports scar reduction
Anti-inflammatory
Enhances skin barrier
Studied for antimicrobial use
Cons:
Limited aesthetic studies
Rare injectable/topical forms
Expensive
Potential irritation
Ease of Access: Very low. Specialized suppliers.
Ease of Use: Moderate. Topical/injectable
Results: Improved acne/scarring in 2-3 months [26].
Source: [26] Heilborn et al., J Invest Dermatol, 2003.
Sourcing: Use real suppliers.
Use: Don’t be retarded, research dosages and how to use stuff (injectables)
Stacking: research this yourself, some stack well some are counterproductive. Some good combos though: Matrixyl + Argireline, BPC-157 + TB-500.
References:
Pickart et al., J Biomater Sci Polym Ed, 2012.
Pickart, Front Chem, 2018.
Uno et al., J Invest Dermatol, 2009.
Schagen, Dermatoendocrinol, 2017.
Sikiric et al., Curr Pharm Des, 2014.
Vukojevic et al., J Clin Med, 2020.
Gjurasin et al., Eur J Pharmacol, 2010.
Teichman et al., J Clin Endocrinol Metab, 2006.
Sigalos et al., Front Endocrinol, 2017.
Wilding et al., N Engl J Med, 2021.
Davies et al., Lancet, 2021.
Blanes-Mira et al., Int J Cosmet Sci, 2002.
Dorr et al., Life Sci, 1996.
Frago et al., Endocrinology, 2002.
Adams et al., J Appl Physiol, 2007.
Deghenghi et al., Endocrine, 2001.
Romani et al., Ann N Y Acad Sci, 2010.
Khavinson et al., Neuro Endocrinol Lett, 2003.
Philp et al., FASEB J, 2004.
McCoy et al., J Med Chem, 2013.
Lintner, Int J Cosmet Sci, 2003.
Gutierrez et al., Cosmet Toiletries, 2009.
Schioth et al., Peptides, 1998.
Heffernan et al., J Clin Endocrinol Metab, 2001.
Ryu et al., J Invest Dermatol, 2019.
Heilborn et al., J Invest Dermatol, 2003.
As i said earlier if you want more added lmk
Ive listed 20. if theres more you want to see reply with them and i may or may not add them
What Are Peptides?
Peptides are short amino acid chains and are also fucking goated. if you aren’t on them or going to get on them you’re wasting potential
Popular Peptides
1. GHK-Cu
Purpose: Skin rejuvenation, wound healing, anti-aging
Overview: stimulates collagen, reduces inflammation, and promotes skin repair [1].
Pros:
Increases collagen and elastin, improving skin firmness [1]
Reduces fine lines and acne scars [2]
Anti-inflammatory, helps with redness [1]
May promote hair growth by supporting follicles [3]
Available topically or as injectable
Cons:
Topical forms have limited penetration [2]
Injectable
Possible temporary stinging/redness [2]
Expensive
Limited human triels
Ease of Access: Moderate. Topical serums available online.
Ease of Use: Topical is simple (apply as serum). Injectables less so.
Results: Smoother skin in 1-2 months; injectables may act faster [2].
Source: [1] Pickart et al., J Biomater Sci Polym Ed, 2012; [2] Pickart, Front Chem, 2018; [3] Uno et al., J Invest Dermatol, 2009.
2. Matrixyl 3000 (Palmitoyl Tripeptide-1 + Palmitoyl Tetrapeptide-7)
Purpose: Anti-aging, wrinkle reduction
Overview: A peptide blend that boosts collagen and reduces inflammation [4].
Pros:
Reduces wrinkles by up to 45% in trials [4]
Enhances skin elasticity/texture [4]
Affordable in serums
Non-irritating for most [4]
Complements retinoids/vitamin C
Cons:
Results take 2-3 months [4]
Minimal effect on deep wrinkles
Avoid low-pH products [4]
Ease of Access: High.
Ease of Use: Very easy apply AM/PM. Wait 20-30 minutes with acids.
Results: Reduced fine lines, improved plumpness in 6-8 weeks [4].
Source: [4] Schagen, Dermatoendocrinol, 2017.
3. BPC-157
Purpose: Tissue repair, gut health, recovery
Overview: A synthetic peptide from a stomach protein, promotes recovery and reduces inflammation [5].
Pros:
Accelerates wound and tissue repair [5]
May improve gut health, aiding skin clarity [6]
Anecdotal reports of reduced acne/scarring
Supports muscle/joint recovery [5]
Some neuroprotection evidence [7]
Cons:
Limited human studies; mostly animal data [5]
Side effects: nausea, blood pressure changes if overdosed
Injectable only
Sourcing tricky due to variable purity
Ease of Access: Low. Sold as research chemicals.
Ease of Use: Moderate. Subcutaneous/intramuscular injections.
Results: Faster recovery, improved skin texture in weeks [6].
Source: [5] Sikiric et al., Curr Pharm Des, 2014; [6] Vukojevic et al., J Clin Med, 2020; [7] Gjurasin et al., Eur J Pharmacol, 2010.
4. CJC-1295 + Ipamorelin
Purpose: Muscle growth, fat loss, anti-aging
Overview: Growth hormone secretagogues that stimulate HGH release, aiding muscle, fat loss, and skin elasticity [8].
Pros:
Enhances muscle mass/recovery [8]
Promotes fat loss via metabolism [9]
May improve skin firmness [8]
Improves sleep/energy (anecdotal)
Cons:
Side effects: joint pain, water retention, insulin resistance [8]
Nightly injections needed
Long-term safety understudied
Expensive
May suppress natural HGH if not cycled [9]
Ease of Access: Low. Available via clinics or peptide suppliers w/ prescription .
Ease of Use: Moderate. Subcutaneous injections.
Results: Musclegain/fat loss in 2-3 months with diet/training [8].
Source: [8] Teichman et al., J Clin Endocrinol Metab, 2006; [9] Sigalos et al., Front Endocrinol, 2017.
5. GLP-1 Agonists (e.g., Reta, Semaglutide, Tirzepatide)
Purpose: Fat loss, metabolic health
Overview: Mimic glucagon-like peptide-1 to regulate appetite and blood sugar, effective for weight loss [10].
Pros:
10-20% body weight loss possible [10]
Improves blood sugar/insulin sensitivity [11]
FDA-approved (Ozempic, Mounjaro)
Weekly injections
Cons:
Side effects: nausea, digestive issues, gallbladder problems [10]
Prescription versions costly
Research chemical versions risky
Plateaus without lifestyle changes
Ease of Access: Moderate. Prescription versions need doctor approval; research versions online.
Ease of Use: High. Weekly subcutaneous injections, titrated dosing.
Results: Fat loss in 3-6 months, skin benefits secondary [11].
Source: [10] Wilding et al., N Engl J Med, 2021; [11] Davies et al., Lancet, 2021.
6. Argireline (Acetyl Hexapeptide-8)
Purpose: Wrinkle reduction, Botox alternative
Overview: Inhibits muscle contractions to reduce dynamic wrinkles, especially on forehead/eyes [12].
Pros:
Reduces expression lines topically [12]
Affordable
Safe
Complements Matrixyl
Easy to use
Cons:
Less effective than Botox [12]
Temporary results, daily use needed
Limited penetration
Minimal effect for some
Avoid strong exfoliants
Ease of Access: High.
Ease of Use: Very easy. Apply twice daily.
Results: Subtle wrinkle reduction in 4-6 weeks [12].
Source: [12] Blanes-Mira et al., Int J Cosmet Sci, 2002.
7. Melanotan II
Purpose: Tanning, libido enhancement
Overview: Stimulates melanin for tanning and may boost libido [13].
Pros:
Natural-looking tan with minimal UV [13]
Enhances skin tone
May increase libido
Fast results (1-2 weeks)
Low-dose effectiveness
Cons:
Side effects: nausea, flushing, moles [13]
Risk of uneven tanning
Careful dosing needed
Ease of Access: Moderate. Sold as research chemicals, quality varies.
Ease of Use: Moderate. Subcutaneous injections with loading phase.
Results: Tan in days to weeks, libido boost for some [13].
Source: [13] Dorr et al., Life Sci, 1996.
8. GHRP-6
Purpose: Muscle growth, fat loss, appetite stimulation
Overview: Stimulates HGH, promoting muscle growth and fat loss, with strong appetite increase [14].
Pros:
Boosts muscle mass/recovery [14]
Enhances fat loss
May improve skin via HGH
Useful for bulking
Affordable vs. other GHRPs
Cons:
Intense hunger spikes [14]
Side effects: water retention, fatigue
Multiple daily injections
Less studied than CJC-1295
Sourcing caution needed
Ease of Access: Moderate. Available from peptide suppliers.
Ease of Use: Low. Frequent injections.
Results: Muscle/fat loss in 2-3 months [14].
Source: [14] Frago et al., Endocrinology, 2002.
9. IGF-1 LR3
Purpose: Muscle growth, fat loss, recovery
Overview: Synthetic insulin-like growth factor, promotes muscle hypertrophy and fat metabolism [15].
Pros:
Potent for muscle growth/recovery [15]
Enhances fat loss
May improve skin firmness
Long-acting, fewer injections
Cons:
Side effects: hypoglycemia, joint pain [15]
Risk of organ growth
Injectable only
Expensive
Ease of Access: Low. Sold as research chemicals.
Ease of Use: Moderate. Subcutaneous injections.
Results: Muscle gains in 1-2 months, subtle skin benefits [15].
Source: [15] Adams et al., J Appl Physiol, 2007.
10. Hexarelin
Purpose: Muscle growth, fat loss, skin health
Overview: Growth hormone secretagogue, stimulates HGH for muscle, fat loss, and potential skin benefits [16].
Pros:
Potent HGH stimulator [16]
May improve skin elasticity
Fast-acting
Enhances strength/recovery
Improves sleep (anecdotal)
Cons:
Increases cortisol/prolactin [16]
Hunger or water retention
Multiple daily injections
Understudied long-term
Hard to source
Ease of Access: Low. Available from peptide suppliers.
Ease of Use: Low. Frequent injections.
Results: Muscle/fat loss in 2-3 months [16].
Source: [16] Deghenghi et al., Endocrine, 2001.
11. Thymosin Alpha-1
Purpose: Immune support, skin health
Overview: Boosts immune function and reduces inflammation [17].
Pros:
Enhances immune response, aiding skin infections [17]
Reduces acne/redness
Supports overall health
Studied for cancer/infections
Cons:
Limited direct skin evidence
Injectable only
Expensive
long-term effects
Ease of Access: Low. Sold by specialized suppliers.
Ease of Use: Moderate. Subcutaneous injections.
Results: Subtle skin clarity in 3-6 months [17].
Source: [17] Romani et al., Ann N Y Acad Sci, 2010.
12. Epitalon
Purpose: Anti-aging, stress resistance
Overview: Activates telomerase to slow cellular aging, potentially improving skin/hair [18].
Pros:
May reduce visible aging [18]
Antioxidant properties
Anecdotal hair/skin benefits
Improves stress resilience
Safe in short cycles
Cons:
Limited human studies
Long-term effects speculative
Injectable only
Hard to source
Expensive
Ease of Access: Low. Niche peptide suppliers.
Ease of Use: Moderate. Subcutaneous injections, short cycles.
Results: Subtle anti-aging after 2-3 cycles [18].
Source: [18] Khavinson et al., Neuro Endocrinol Lett, 2003.
13. TB-500 (Thymosin Beta-4)
Purpose: Tissue repair, hair growth, recovery
Overview: Promotes cell migration and tissue repair, used for recovery and potential hair regrowth [19].
Pros:
Accelerates muscle/tendon/skin healing [19]
Anecdotal hair regrowth
Reduces inflammation
Synergizes with BPC-157
Cons:
Limited human hair data
Side effects: fatigue, headaches
Injectable only
Expensive
Ease of Access: Low. Research chemical suppliers.
Ease of Use: Moderate. Subcutaneous/intramuscular injections.
Results: Recovery in weeks; hair growth inconsistent [19].
Source: [19] Philp et al., FASEB J, 2004.
14. Dihexa
Purpose: Cognitive enhancement, skin repair
Overview: Enhances brain function and may promote skin/hair via angiogenesis [20].
Pros:
Stimulates tissue repair/blood vessel growth [20]
Anecdotal hair thickness
May boost mental clarity
Oral/topical forms available
anti-aging interest
Cons:
Limited human studies
Side effects unclear
Low oral bioavailability
Very hard to source
Expensive
Ease of Access: Very low. Select research suppliers.
Ease of Use: Moderate. Topical/oral easier than injectables.
Results: Speculative skin/hair benefits; cognitive effects stronger [20].
Source: [20] McCoy et al., J Med Chem, 2013.
15. Pentapeptide-3 (Vialox)
Purpose: Wrinkle reduction
Overview: Inhibits muscle contractions, similar to Argireline, targeting dynamic wrinkles [21].
Pros:
Reduces fine lines [21]
Non-invasive Botox alternative
Safe for topical use
Complements other peptides
Affordable in some serums
Cons:
Less effective than Botox
Daily use needed
Limited penetration
Less studied than Argireline
Ease of Access: Moderate. Niche serums.
Ease of Use: Very easy. Apply daily.
Results: Subtle wrinkle reduction in 4-6 weeks [21].
Source: [21] Lintner, Int J Cosmet Sci, 2003.
16. Snap-8 (Acetyl Octapeptide-3)
Purpose: Wrinkle reduction
Overview: Advanced Argireline, inhibits muscle contractions for deeper wrinkles [22].
Pros:
More potent than Argireline [22]
Safe for topical use
Enhances smoothness
Works with other peptides
Non-irritating
Cons:
Less effective than Botox
Daily use required
Limited availability
Higher cost
Penetration issues
Ease of Access: Moderate. Premium serums.
Ease of Use: Very easy. Apply daily.
Results: Wrinkle reduction in 6-8 weeks [22].
Source: [22] Gutierrez et al., Cosmet Toiletries, 2009.
17. DSIP (Delta Sleep-Inducing Peptide)
Purpose: Sleep enhancement, stress reduction
Overview: Promotes deep sleep, reducing cortisol [23].
Pros:
Improves sleep, aiding skin repair [23]
May reduce cortisol-related skin issues
Supports recovery
Well-tolerated
Anecdotal mood benefits
Cons:
Limited direct aesthetic benefits
Injectable only
Hard to source
Variable effects
Minimal human studies
Ease of Access: Low. Niche suppliers.
Ease of Use: Moderate. Subcutaneous injections pre-bed.
Results: Better sleep in days, indirect skin benefits [23].
Source: [23] Schioth et al., Peptides, 1998.
18. AOD-9604
Purpose: Fat loss, metabolism
Overview: HGH fragment targeting fat metabolism without muscle or blood sugar effects [24].
Pros:
Promotes fat loss [24]
Minimal side effects vs. HGH
May improve skin via fat reduction
Well-studied for obesity
Simple dosing
Cons:
Limited muscle benefits
Requires diet/exercise
Expensive
Ease of Access: Moderate. Research chemical suppliers.
Ease of Use: Moderate. Daily subcutaneous injections.
Results: Fat loss in 2-3 months [24].
Source: [24] Heffernan et al., J Clin Endocrinol Metab, 2001.
19. PTD-DBM
Purpose: Hair regrowth
Overview: Activates Wnt/β-catenin pathway for hair follicle growth, often with microneedling [25].
Pros:
Enhances hair thickness
Topical application
Synergizes with microneedling
hair restoration interest
Cons:
Limited clinical data
Consistent application needed
Hard to source
Expensive
Microneedling enhances results
Ease of Access: Low. Niche research suppliers.
Ease of Use: Moderate. Topical, often with microneedling.
Results: Hair regrowth in 3-6 months [25].
Source: [25] Ryu et al., J Invest Dermatol, 2019.
20. LL-37
Purpose: Skin health, antimicrobial
Overview: Antimicrobial peptide that fights skin infections and promotes wound healing [26].
Pros:
Reduces acne-causing bacteria [26]
Supports scar reduction
Anti-inflammatory
Enhances skin barrier
Studied for antimicrobial use
Cons:
Limited aesthetic studies
Rare injectable/topical forms
Expensive
Potential irritation
Ease of Access: Very low. Specialized suppliers.
Ease of Use: Moderate. Topical/injectable
Results: Improved acne/scarring in 2-3 months [26].
Source: [26] Heilborn et al., J Invest Dermatol, 2003.
Sourcing: Use real suppliers.
Use: Don’t be retarded, research dosages and how to use stuff (injectables)
Stacking: research this yourself, some stack well some are counterproductive. Some good combos though: Matrixyl + Argireline, BPC-157 + TB-500.
References:
Pickart et al., J Biomater Sci Polym Ed, 2012.
Pickart, Front Chem, 2018.
Uno et al., J Invest Dermatol, 2009.
Schagen, Dermatoendocrinol, 2017.
Sikiric et al., Curr Pharm Des, 2014.
Vukojevic et al., J Clin Med, 2020.
Gjurasin et al., Eur J Pharmacol, 2010.
Teichman et al., J Clin Endocrinol Metab, 2006.
Sigalos et al., Front Endocrinol, 2017.
Wilding et al., N Engl J Med, 2021.
Davies et al., Lancet, 2021.
Blanes-Mira et al., Int J Cosmet Sci, 2002.
Dorr et al., Life Sci, 1996.
Frago et al., Endocrinology, 2002.
Adams et al., J Appl Physiol, 2007.
Deghenghi et al., Endocrine, 2001.
Romani et al., Ann N Y Acad Sci, 2010.
Khavinson et al., Neuro Endocrinol Lett, 2003.
Philp et al., FASEB J, 2004.
McCoy et al., J Med Chem, 2013.
Lintner, Int J Cosmet Sci, 2003.
Gutierrez et al., Cosmet Toiletries, 2009.
Schioth et al., Peptides, 1998.
Heffernan et al., J Clin Endocrinol Metab, 2001.
Ryu et al., J Invest Dermatol, 2019.
Heilborn et al., J Invest Dermatol, 2003.
As i said earlier if you want more added lmk
