Info Semaglutide, Single Agonist and Retatrutide, Triple Agonist

[BlendedBulge]

also i never said it was more effective than reta at fat loss, only at its intended site

Sorry my bad, I thought you said it’s more effective drug in general

 

[pompompurino]

Sorry my bad, I thought you said it’s more effective drug in general

no you’re fine i think they’re great in their own ways, depends on the person who wants to take it and what they want the outcomes to be

 

[The cat from The Matrix]

Pompom im fucking scared do u be bleeding when do u ts i ain't never done nothin like this before

 

[based god gigi]

(I’ve only done research on these two weight loss drugs and have personally used semaglutide. I’ll do a thread on others in the future, possibly?
Also, if you’re in the US and want a source, PM me).


Some terms to know as you read -

K-cells : These are hormone-producing cells found in your upper intestines that sense nutrients. They release the GIP hormone. These cells work before L-cells and actually give L-cells early indirect signals that begin THEIR process.

GIP : Glucuse-dependent Insulinotrophic Polypeptide, a gut hormone that helps your body release insulin to help control blood sugar.

L-cells : These are hormone-producing cells that are found in your lower intestines that sense nutrients. They release the hormones GLP-1, PYY, OXM.

GLP-1 : Glucagon-Like Peptide-1, a gut hormone that lowers blood sugar, increases insulin, decreases appetite.

PYY : Peptide YY, a gut hormone that makes you feel full.

OXM : Oxyntomodulin, a gut hormone that also makes you feel full, may increase energy expenditure, and also mildly lowers blood sugar.

Glucagon : A hormone secreted by the pancreas. Raises blood sugar.

Insulin : A hormone secreted by the pancreas. Lowers blood sugar.

Duodenum : First part of the small intestine.

Jejunum : Middle part of the small intestine.

Ileum : Last part of the small intestine.

Colon : ‘Large intestine’ that starts after the ileum, made up of many sections.

Pancreas : Gland located behind stomach that plays a role in digestion and blood sugar control.


How does our body endogenously produce GLP-1 + more? -

After food is consumed, it moves into the stomach and small intestine.
K-cells, located in the upper intestines (duodenum, jejeunum) are first to respond. Within minutes of eating, they sense nutrients and release GIP.
This stimulates insulin release from the pancreas.
A bit later, around 10-15 minutes after eating,
L-cells, located in the lower intestines (ileum, colon), will also sense the presence of nutrients. These early signals begin the process which are sent indirectly by the upper intestines.
L-cells then release GLP-1, PYY, and OXM.
These hormones act on the brain, creating the sensation of fullness + satiation.

Semaglutide -

You may know this drug as it’s gotten quite popular, known brand names are Ozempic and Wegovy.

This drug only affects GLP-1 receptors (GLP-1R). Relative to retatrutide it is much more effective at the intended target. This means semaglutide would be best for you if your only concern is decreasing your appetite. You would need much less of a dosage.

Evidence demonstrates that semaglutide results in suppressed hunger, augmented satiation + insulin secretion, inhibition of glucagon release, suppressed hepatic gluconeogenisis, and delayed gastric emptying. Semaglutide is around 94% similar to the native GLP-1 we produce naturally in our intestines.

Scientists developed GLP-1 receptor agonists such as semaglutide because naturally occurring GLP-1 is rapidly degraded, a half-life of 1-2 minutes. The issue with a longer-acting version that resists break down is that it will cause gastrointestinal side effects like nausea, vomitting, diarrhea, etc.


Retatrutide -

Retatrutide still goes by only ‘retatrutide’ for now, as there are no brands for it. (In one study I used it goes by LY3437943). It has been gaining traction through tiktok with many fitness influencers recommending it.

It is still fairly new and still undergoing clinical trials at this time. This drug affects GLP-1R, GIP-R, and glucagon receptors.

Retatrutide is around 2.5x weaker than naturally occurring GLP-1 and around 2.9x weaker than glucagon. On the other hand, it’s super strong at activating GIP receptors, 9x stronger than natural GIP. This would mean that it boosts the effects of both GIP + GLP-1 in a way that functions alongside each other, because they have overlapping pathways. The fact that it’s weaker than both natural GLP-1 + glucagon makes the effects more balanced, leading to less shitty side effects compared to semaglutide.

Glucagon raises heart rate, increases how hard the heart pumps, and improves blood flow in the lungs. Unfortunately, the glucagon we naturally produce has a short half-life just like GLP-1, so scientists decided to make this drug to mimic it. Retatrutide is a mild glucagon agonist, so you will feel these benefits. It will also depend on the dosages. Retatrutide would be best for you if you go to the gym, are an active person, or you just don’t want as shitty side effects as semaglutide.


Personal Anecdotes (Semaglutide) -

My experience with semaglutide is still ongoing, literally injected a day ago or so. I haven’t experienced any major side effects yet. One thing that pmo is the sulfur burps, taste like actual SHIT. It only happens if you eat slop though, SO eat a good diet if you plan to take this stuff. Also, if you are planning on taking this EAT ENOUGH. Even if you aren’t hungry. You WILL feel fatigued if you don’t eat enough,
starving is never the answer.
Some favorable outcomes have been not feeling hungry whatsoever, I don’t impulsively eat, and I feel like getting lean is easy as shit. Feeling like getting lean is easy as shit is really helpful to me mentally so maybe it’ll be helpful mentally to you guys as well?


Linking research below!


tagging ppl who might read ts
@Randomized Shame
@delilahjones
@Mota
@NewFuckingDay

woaw this is sick pom thanks for this

 

[BlendedBulge]

Pompom im fucking scared do u be bleeding when do u ts i ain't never done nothin like this before

I’m used to pin and it’s very easy esp with these pen needles, you might hit a blood vessel (unlikely with such a small needle), and have some bleeding, but it’s totally fine don’t worry

Not painful at all

 

[pompompurino]

Pompom im fucking scared do u be bleeding when do u ts i ain't never done nothin like this before

nooo no bleeding, i’ve never even threw up from it. injecting urself won’t cause any bleeding either, needles are designed not to cause big wounds that would cause bleeding

 

[pompompurino]

I’m used to pin and it’s very easy esp with these pen needles, you might hit a blood vessel (unlikely with such a small needle), and have some bleeding, but it’s totally fine don’t worry

Not painful at all

i’ve yet to bleed i’m nervous now, but cat don’t be scared trust me

 

[pompompurino]

woaw this is sick pom thanks for this

thank you

 

[BlendedBulge]

i’ve yet to bleed i’m nervous now, but cat don’t be scared trust me

Nah it’s very rare with small needles subq, it’s more likely to occur if you do IM injection

And even then it’s more psychological it’s like 3-5 drops of blood

 

[BlendedBulge]

I’ve tried sema and now want to try retatrutide, with sema I got slight nausea but apart from this everything’s great

 

[pompompurino]

I’ve tried sema and now want to try retatrutide, with sema I got slight nausea but apart from this everything’s great

let me know how retatrutide goes for you! it’s interesting to me

 

[Deleted Member 70402]

Amazing, deserves to be stickied in Must Reads

 

[pompompurino]

I used all of these as references for my post too. (I didn't read the Hemodynamic Effects of Glucagon: A Literature Review one though) Funny. I guess it's because there's not a lot of sources to pull from.

REALLY? nice we are on the same wavelength

 

[pompompurino]

Amazing, deserves to be stickied in Must Reads

LETS GO I MADE TO MUST READS

 

[BlendedBulge]

REALLY? nice we are on the same wavelength

Warning: High levels of intellectual resonance may cause spontaneous nerdiness.

 

[victorique]

(I’ve only done research on these two weight loss drugs and have personally used semaglutide. I’ll do a thread on others in the future, possibly?
Also, if you’re in the US and want a source, PM me).


Some terms to know as you read -

K-cells : These are hormone-producing cells found in your upper intestines that sense nutrients. They release the GIP hormone. These cells work before L-cells and actually give L-cells early indirect signals that begin THEIR process.

GIP : Glucuse-dependent Insulinotrophic Polypeptide, a gut hormone that helps your body release insulin to help control blood sugar.

L-cells : These are hormone-producing cells that are found in your lower intestines that sense nutrients. They release the hormones GLP-1, PYY, OXM.

GLP-1 : Glucagon-Like Peptide-1, a gut hormone that lowers blood sugar, increases insulin, decreases appetite.

PYY : Peptide YY, a gut hormone that makes you feel full.

OXM : Oxyntomodulin, a gut hormone that also makes you feel full, may increase energy expenditure, and also mildly lowers blood sugar.

Glucagon : A hormone secreted by the pancreas. Raises blood sugar.

Insulin : A hormone secreted by the pancreas. Lowers blood sugar.

Duodenum : First part of the small intestine.

Jejunum : Middle part of the small intestine.

Ileum : Last part of the small intestine.

Colon : ‘Large intestine’ that starts after the ileum, made up of many sections.

Pancreas : Gland located behind stomach that plays a role in digestion and blood sugar control.


How does our body endogenously produce GLP-1 + more? -

After food is consumed, it moves into the stomach and small intestine.
K-cells, located in the upper intestines (duodenum, jejeunum) are first to respond. Within minutes of eating, they sense nutrients and release GIP.
This stimulates insulin release from the pancreas.
A bit later, around 10-15 minutes after eating,
L-cells, located in the lower intestines (ileum, colon), will also sense the presence of nutrients. These early signals begin the process which are sent indirectly by the upper intestines.
L-cells then release GLP-1, PYY, and OXM.
These hormones act on the brain, creating the sensation of fullness + satiation.

Semaglutide -

You may know this drug as it’s gotten quite popular, known brand names are Ozempic and Wegovy.

This drug only affects GLP-1 receptors (GLP-1R). Relative to retatrutide it is much more effective at the intended target. This means semaglutide would be best for you if your only concern is decreasing your appetite. You would need much less of a dosage.

Evidence demonstrates that semaglutide results in suppressed hunger, augmented satiation + insulin secretion, inhibition of glucagon release, suppressed hepatic gluconeogenisis, and delayed gastric emptying. Semaglutide is around 94% similar to the native GLP-1 we produce naturally in our intestines.

Scientists developed GLP-1 receptor agonists such as semaglutide because naturally occurring GLP-1 is rapidly degraded, a half-life of 1-2 minutes. The issue with a longer-acting version that resists break down is that it will cause gastrointestinal side effects like nausea, vomitting, diarrhea, etc.


Retatrutide -

Retatrutide still goes by only ‘retatrutide’ for now, as there are no brands for it. (In one study I used it goes by LY3437943). It has been gaining traction through tiktok with many fitness influencers recommending it.

It is still fairly new and still undergoing clinical trials at this time. This drug affects GLP-1R, GIP-R, and glucagon receptors.

Retatrutide is around 2.5x weaker than naturally occurring GLP-1 and around 2.9x weaker than glucagon. On the other hand, it’s super strong at activating GIP receptors, 9x stronger than natural GIP. This would mean that it boosts the effects of both GIP + GLP-1 in a way that functions alongside each other, because they have overlapping pathways. The fact that it’s weaker than both natural GLP-1 + glucagon makes the effects more balanced, leading to less shitty side effects compared to semaglutide.

Glucagon raises heart rate, increases how hard the heart pumps, and improves blood flow in the lungs. Unfortunately, the glucagon we naturally produce has a short half-life just like GLP-1, so scientists decided to make this drug to mimic it. Retatrutide is a mild glucagon agonist, so you will feel these benefits. It will also depend on the dosages. Retatrutide would be best for you if you go to the gym, are an active person, or you just don’t want as shitty side effects as semaglutide.


Personal Anecdotes (Semaglutide) -

My experience with semaglutide is still ongoing, literally injected a day ago or so. I haven’t experienced any major side effects yet. One thing that pmo is the sulfur burps, taste like actual SHIT. It only happens if you eat slop though, SO eat a good diet if you plan to take this stuff. Also, if you are planning on taking this EAT ENOUGH. Even if you aren’t hungry. You WILL feel fatigued if you don’t eat enough,
starving is never the answer.
Some favorable outcomes have been not feeling hungry whatsoever, I don’t impulsively eat, and I feel like getting lean is easy as shit. Feeling like getting lean is easy as shit is really helpful to me mentally so maybe it’ll be helpful mentally to you guys as well?


Linking research below!


tagging ppl who might read ts
@Randomized Shame
@delilahjones
@Mota
@NewFuckingDay

@Promises i like how jfled this thread like me

 

[Deleted Member 70402]

LETS GO I MADE TO MUST READS

WOOO HOOO

 

[interstellarpotato]

(I’ve only done research on these two weight loss drugs and have personally used semaglutide. I’ll do a thread on others in the future, possibly?
Also, if you’re in the US and want a source, PM me).


Some terms to know as you read -

K-cells : These are hormone-producing cells found in your upper intestines that sense nutrients. They release the GIP hormone. These cells work before L-cells and actually give L-cells early indirect signals that begin THEIR process.

GIP : Glucuse-dependent Insulinotrophic Polypeptide, a gut hormone that helps your body release insulin to help control blood sugar.

L-cells : These are hormone-producing cells that are found in your lower intestines that sense nutrients. They release the hormones GLP-1, PYY, OXM.

GLP-1 : Glucagon-Like Peptide-1, a gut hormone that lowers blood sugar, increases insulin, decreases appetite.

PYY : Peptide YY, a gut hormone that makes you feel full.

OXM : Oxyntomodulin, a gut hormone that also makes you feel full, may increase energy expenditure, and also mildly lowers blood sugar.

Glucagon : A hormone secreted by the pancreas. Raises blood sugar.

Insulin : A hormone secreted by the pancreas. Lowers blood sugar.

Duodenum : First part of the small intestine.

Jejunum : Middle part of the small intestine.

Ileum : Last part of the small intestine.

Colon : ‘Large intestine’ that starts after the ileum, made up of many sections.

Pancreas : Gland located behind stomach that plays a role in digestion and blood sugar control.


How does our body endogenously produce GLP-1 + more? -

After food is consumed, it moves into the stomach and small intestine.
K-cells, located in the upper intestines (duodenum, jejeunum) are first to respond. Within minutes of eating, they sense nutrients and release GIP.
This stimulates insulin release from the pancreas.
A bit later, around 10-15 minutes after eating,
L-cells, located in the lower intestines (ileum, colon), will also sense the presence of nutrients. These early signals begin the process which are sent indirectly by the upper intestines.
L-cells then release GLP-1, PYY, and OXM.
These hormones act on the brain, creating the sensation of fullness + satiation.

Semaglutide -

You may know this drug as it’s gotten quite popular, known brand names are Ozempic and Wegovy.

This drug only affects GLP-1 receptors (GLP-1R). Relative to retatrutide it is much more effective at the intended target. This means semaglutide would be best for you if your only concern is decreasing your appetite. You would need much less of a dosage.

Evidence demonstrates that semaglutide results in suppressed hunger, augmented satiation + insulin secretion, inhibition of glucagon release, suppressed hepatic gluconeogenisis, and delayed gastric emptying. Semaglutide is around 94% similar to the native GLP-1 we produce naturally in our intestines.

Scientists developed GLP-1 receptor agonists such as semaglutide because naturally occurring GLP-1 is rapidly degraded, a half-life of 1-2 minutes. The issue with a longer-acting version that resists break down is that it will cause gastrointestinal side effects like nausea, vomitting, diarrhea, etc.


Retatrutide -

Retatrutide still goes by only ‘retatrutide’ for now, as there are no brands for it. (In one study I used it goes by LY3437943). It has been gaining traction through tiktok with many fitness influencers recommending it.

It is still fairly new and still undergoing clinical trials at this time. This drug affects GLP-1R, GIP-R, and glucagon receptors.

Retatrutide is around 2.5x weaker than naturally occurring GLP-1 and around 2.9x weaker than glucagon. On the other hand, it’s super strong at activating GIP receptors, 9x stronger than natural GIP. This would mean that it boosts the effects of both GIP + GLP-1 in a way that functions alongside each other, because they have overlapping pathways. The fact that it’s weaker than both natural GLP-1 + glucagon makes the effects more balanced, leading to less shitty side effects compared to semaglutide.

Glucagon raises heart rate, increases how hard the heart pumps, and improves blood flow in the lungs. Unfortunately, the glucagon we naturally produce has a short half-life just like GLP-1, so scientists decided to make this drug to mimic it. Retatrutide is a mild glucagon agonist, so you will feel these benefits. It will also depend on the dosages. Retatrutide would be best for you if you go to the gym, are an active person, or you just don’t want as shitty side effects as semaglutide.


Personal Anecdotes (Semaglutide) -

My experience with semaglutide is still ongoing, literally injected a day ago or so. I haven’t experienced any major side effects yet. One thing that pmo is the sulfur burps, taste like actual SHIT. It only happens if you eat slop though, SO eat a good diet if you plan to take this stuff. Also, if you are planning on taking this EAT ENOUGH. Even if you aren’t hungry. You WILL feel fatigued if you don’t eat enough,
starving is never the answer.
Some favorable outcomes have been not feeling hungry whatsoever, I don’t impulsively eat, and I feel like getting lean is easy as shit. Feeling like getting lean is easy as shit is really helpful to me mentally so maybe it’ll be helpful mentally to you guys as well?


Linking research below!


tagging ppl who might read ts
@Randomized Shame
@delilahjones
@Mota
@NewFuckingDay

What do u mean PM you
I'm in the US I just locally doctor shopped and now my stuff is coming in the mail
??? Are you getting yours from some website??????

 

[pompompurino]

What do u mean PM you
I'm in the US I just locally doctor shopped and now my stuff is coming in the mail
??? Are you getting yours from some website??????

like private message me if u want a source and ur from the us
im getting mine from a website, yes

 

[interstellarpotato]

(I’ve only done research on these two weight loss drugs and have personally used semaglutide. I’ll do a thread on others in the future, possibly?
Also, if you’re in the US and want a source, PM me).


Some terms to know as you read -

K-cells : These are hormone-producing cells found in your upper intestines that sense nutrients. They release the GIP hormone. These cells work before L-cells and actually give L-cells early indirect signals that begin THEIR process.

GIP : Glucuse-dependent Insulinotrophic Polypeptide, a gut hormone that helps your body release insulin to help control blood sugar.

L-cells : These are hormone-producing cells that are found in your lower intestines that sense nutrients. They release the hormones GLP-1, PYY, OXM.

GLP-1 : Glucagon-Like Peptide-1, a gut hormone that lowers blood sugar, increases insulin, decreases appetite.

PYY : Peptide YY, a gut hormone that makes you feel full.

OXM : Oxyntomodulin, a gut hormone that also makes you feel full, may increase energy expenditure, and also mildly lowers blood sugar.

Glucagon : A hormone secreted by the pancreas. Raises blood sugar.

Insulin : A hormone secreted by the pancreas. Lowers blood sugar.

Duodenum : First part of the small intestine.

Jejunum : Middle part of the small intestine.

Ileum : Last part of the small intestine.

Colon : ‘Large intestine’ that starts after the ileum, made up of many sections.

Pancreas : Gland located behind stomach that plays a role in digestion and blood sugar control.


How does our body endogenously produce GLP-1 + more? -

After food is consumed, it moves into the stomach and small intestine.
K-cells, located in the upper intestines (duodenum, jejeunum) are first to respond. Within minutes of eating, they sense nutrients and release GIP.
This stimulates insulin release from the pancreas.
A bit later, around 10-15 minutes after eating,
L-cells, located in the lower intestines (ileum, colon), will also sense the presence of nutrients. These early signals begin the process which are sent indirectly by the upper intestines.
L-cells then release GLP-1, PYY, and OXM.
These hormones act on the brain, creating the sensation of fullness + satiation.

Semaglutide -

You may know this drug as it’s gotten quite popular, known brand names are Ozempic and Wegovy.

This drug only affects GLP-1 receptors (GLP-1R). Relative to retatrutide it is much more effective at the intended target. This means semaglutide would be best for you if your only concern is decreasing your appetite. You would need much less of a dosage.

Evidence demonstrates that semaglutide results in suppressed hunger, augmented satiation + insulin secretion, inhibition of glucagon release, suppressed hepatic gluconeogenisis, and delayed gastric emptying. Semaglutide is around 94% similar to the native GLP-1 we produce naturally in our intestines.

Scientists developed GLP-1 receptor agonists such as semaglutide because naturally occurring GLP-1 is rapidly degraded, a half-life of 1-2 minutes. The issue with a longer-acting version that resists break down is that it will cause gastrointestinal side effects like nausea, vomitting, diarrhea, etc.


Retatrutide -

Retatrutide still goes by only ‘retatrutide’ for now, as there are no brands for it. (In one study I used it goes by LY3437943). It has been gaining traction through tiktok with many fitness influencers recommending it.

It is still fairly new and still undergoing clinical trials at this time. This drug affects GLP-1R, GIP-R, and glucagon receptors.

Retatrutide is around 2.5x weaker than naturally occurring GLP-1 and around 2.9x weaker than glucagon. On the other hand, it’s super strong at activating GIP receptors, 9x stronger than natural GIP. This would mean that it boosts the effects of both GIP + GLP-1 in a way that functions alongside each other, because they have overlapping pathways. The fact that it’s weaker than both natural GLP-1 + glucagon makes the effects more balanced, leading to less shitty side effects compared to semaglutide.

Glucagon raises heart rate, increases how hard the heart pumps, and improves blood flow in the lungs. Unfortunately, the glucagon we naturally produce has a short half-life just like GLP-1, so scientists decided to make this drug to mimic it. Retatrutide is a mild glucagon agonist, so you will feel these benefits. It will also depend on the dosages. Retatrutide would be best for you if you go to the gym, are an active person, or you just don’t want as shitty side effects as semaglutide.


Personal Anecdotes (Semaglutide) -

My experience with semaglutide is still ongoing, literally injected a day ago or so. I haven’t experienced any major side effects yet. One thing that pmo is the sulfur burps, taste like actual SHIT. It only happens if you eat slop though, SO eat a good diet if you plan to take this stuff. Also, if you are planning on taking this EAT ENOUGH. Even if you aren’t hungry. You WILL feel fatigued if you don’t eat enough,
starving is never the answer.
Some favorable outcomes have been not feeling hungry whatsoever, I don’t impulsively eat, and I feel like getting lean is easy as shit. Feeling like getting lean is easy as shit is really helpful to me mentally so maybe it’ll be helpful mentally to you guys as well?


Linking research below!


tagging ppl who might read ts
@Randomized Shame
@delilahjones
@Mota
@NewFuckingDay

can't find retratruride though

 

[pompompurino]

can't find retratruride though

the site i use has reta

 

[interstellarpotato]

the site i use has reta

I will PM you in a couple months after my sema comes in but i think i will waste away before that point

Good to know how do u find this shi tho cause im just paying a shitty physician

 

[pompompurino]

I will PM you in a couple months after my sema comes in but i think i will waste away before that point

yea yea, just pm me whenever
also im sure you’ll do just fine on sema, im on it rn and its fine

Good to know how do u find this shi tho cause im just paying a shitty physician

bro they are so expensive for no reason

 

[interstellarpotato]

yea yea, just pm me whenever
also im sure you’ll do just fine on sema, im on it rn and its fine

bro they are so expensive for no reason

how much are u paying u share first

 

[Randomized]

like private message me if u want a source and ur from the us
im getting mine from a website, yes

I'm curious. Are you willing to send it to me privately?

 

[Deleted Member 38826]

(I’ve only done research on these two weight loss drugs and have personally used semaglutide. I’ll do a thread on others in the future, possibly?
Also, if you’re in the US and want a source, PM me).


Some terms to know as you read -

K-cells : These are hormone-producing cells found in your upper intestines that sense nutrients. They release the GIP hormone. These cells work before L-cells and actually give L-cells early indirect signals that begin THEIR process.

GIP : Glucuse-dependent Insulinotrophic Polypeptide, a gut hormone that helps your body release insulin to help control blood sugar.

L-cells : These are hormone-producing cells that are found in your lower intestines that sense nutrients. They release the hormones GLP-1, PYY, OXM.

GLP-1 : Glucagon-Like Peptide-1, a gut hormone that lowers blood sugar, increases insulin, decreases appetite.

PYY : Peptide YY, a gut hormone that makes you feel full.

OXM : Oxyntomodulin, a gut hormone that also makes you feel full, may increase energy expenditure, and also mildly lowers blood sugar.

Glucagon : A hormone secreted by the pancreas. Raises blood sugar.

Insulin : A hormone secreted by the pancreas. Lowers blood sugar.

Duodenum : First part of the small intestine.

Jejunum : Middle part of the small intestine.

Ileum : Last part of the small intestine.

Colon : ‘Large intestine’ that starts after the ileum, made up of many sections.

Pancreas : Gland located behind stomach that plays a role in digestion and blood sugar control.


How does our body endogenously produce GLP-1 + more? -

After food is consumed, it moves into the stomach and small intestine.
K-cells, located in the upper intestines (duodenum, jejeunum) are first to respond. Within minutes of eating, they sense nutrients and release GIP.
This stimulates insulin release from the pancreas.
A bit later, around 10-15 minutes after eating,
L-cells, located in the lower intestines (ileum, colon), will also sense the presence of nutrients. These early signals begin the process which are sent indirectly by the upper intestines.
L-cells then release GLP-1, PYY, and OXM.
These hormones act on the brain, creating the sensation of fullness + satiation.

Semaglutide -

You may know this drug as it’s gotten quite popular, known brand names are Ozempic and Wegovy.

This drug only affects GLP-1 receptors (GLP-1R). Relative to retatrutide it is much more effective at the intended target. This means semaglutide would be best for you if your only concern is decreasing your appetite. You would need much less of a dosage.

Evidence demonstrates that semaglutide results in suppressed hunger, augmented satiation + insulin secretion, inhibition of glucagon release, suppressed hepatic gluconeogenisis, and delayed gastric emptying. Semaglutide is around 94% similar to the native GLP-1 we produce naturally in our intestines.

Scientists developed GLP-1 receptor agonists such as semaglutide because naturally occurring GLP-1 is rapidly degraded, a half-life of 1-2 minutes. The issue with a longer-acting version that resists break down is that it will cause gastrointestinal side effects like nausea, vomitting, diarrhea, etc.


Retatrutide -

Retatrutide still goes by only ‘retatrutide’ for now, as there are no brands for it. (In one study I used it goes by LY3437943). It has been gaining traction through tiktok with many fitness influencers recommending it.

It is still fairly new and still undergoing clinical trials at this time. This drug affects GLP-1R, GIP-R, and glucagon receptors.

Retatrutide is around 2.5x weaker than naturally occurring GLP-1 and around 2.9x weaker than glucagon. On the other hand, it’s super strong at activating GIP receptors, 9x stronger than natural GIP. This would mean that it boosts the effects of both GIP + GLP-1 in a way that functions alongside each other, because they have overlapping pathways. The fact that it’s weaker than both natural GLP-1 + glucagon makes the effects more balanced, leading to less shitty side effects compared to semaglutide.

Glucagon raises heart rate, increases how hard the heart pumps, and improves blood flow in the lungs. Unfortunately, the glucagon we naturally produce has a short half-life just like GLP-1, so scientists decided to make this drug to mimic it. Retatrutide is a mild glucagon agonist, so you will feel these benefits. It will also depend on the dosages. Retatrutide would be best for you if you go to the gym, are an active person, or you just don’t want as shitty side effects as semaglutide.


Personal Anecdotes (Semaglutide) -

My experience with semaglutide is still ongoing, literally injected a day ago or so. I haven’t experienced any major side effects yet. One thing that pmo is the sulfur burps, taste like actual SHIT. It only happens if you eat slop though, SO eat a good diet if you plan to take this stuff. Also, if you are planning on taking this EAT ENOUGH. Even if you aren’t hungry. You WILL feel fatigued if you don’t eat enough,
starving is never the answer.
Some favorable outcomes have been not feeling hungry whatsoever, I don’t impulsively eat, and I feel like getting lean is easy as shit. Feeling like getting lean is easy as shit is really helpful to me mentally so maybe it’ll be helpful mentally to you guys as well?


Linking research below!


tagging ppl who might read ts
@Randomized Shame
@delilahjones
@Mota
@NewFuckingDay

just stick the needle in your ass bro

 

[pompompurino]

I'm curious. Are you willing to send it to me privately?

i saw this so late. of course, i’ll pm you!

 

[pompompurino]

how much are u paying u share first

the sema i buy is $60, if im remembering correctly

 

[Mota]

bro forgot im a mod

makes sense, just read the whole thread and this in must-reads now and orange and shit

 

[pompompurino]

makes sense, just read the whole thread and this in must-reads now and orange and shit

i fixed it after some helpful constructive criticism, this makes it easier to read i think

 

[Deleted Member 61421]

i fixed it after some helpful constructive criticism, this makes it easier to read i think

why is ur name now orange i liked it black it was tuff

 

[Deleted Member 64971]

research unknown topics

 

[pompompurino]

research unknown topics

?

 

[pompompurino]

why is ur name now orange i liked it black it was tuff

i wanted to try a new color, i’ve done black for so long

 

[Deleted Member 64971]

?

what

 

[Deleted Member 61421]

i wanted to try a new color, i’ve done black for so long

how do I pick my colours I want black, do i have to be fucking mod

 

[pompompurino]

what

are you saying i should research unknown topics im confused lol

 

[pompompurino]

how do I pick my colours I want black, do i have to be fucking mod

be staff or get motm

 

[Deleted Member 64971]

are you saying i should research unknown topics im confused lol

nah i meant you should make me a burger with no ketchup

 

[berezki]

if youre already at a normal ish weight or if youre lean and want to get shredded the downside is not worth it. glp 1 agonists suppress your appetite-> you eat less ->youre in a caloric deficit BUT the problem with big deficits and rapid weight loss is that 1. a significant amount comes from muscle ( UP TO 40% of the weight thats lost) especially if youre neglecting weight training and protein 2. your body adapts to fewer calories if you do it for enough time (metabolic adaptation). so both of these cause your metabolism to slow down which means that the down the line to lose weight you will need to be eating even less (your deficit becomes your maintenance) and eating a normal portion will cause weight gain. in the long run its really not worth it (if youre not overweight)