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Testosterone
the primary endogenous sex hormone in men, is a bioidentical
anabolic-androgenic steroid (AAS) essential for male physiology. Many people think of
testosterone as the boring default androgen that has no interesting properties apart
from agonizing the androgen receptor, but this is not true. Testosterone does have some
unique properties that deviate it from being purely an androgen receptor agonist.
WISP-2 mRNA expression
Testosterone promotes muscle growth and fat loss by increasing WISP-2 mRNA
expression (likely due to its aromatization into estradiol), which regulates growth factors
like IGF-1 and TGF-β. WISP-2 enhances lean mass, reduces fat, and improves insulin


sensitivity
Insulin sensitivity
Testosterone increases insulin sensitivity primarily through its metabolism into estradiol
and DHT. It decreases glucocorticoids (cortisol) in the liver through 5a-reductase, which
decreases catabolism and increases insulin sensitivity. It also greatly increases glucose
metabolism through its aromatization into estradiol and subsequ ent agonism of ER-a


A Verified Halhal
the primary endogenous sex hormone in men, is a bioidentical
anabolic-androgenic steroid (AAS) essential for male physiology. Many people think of
testosterone as the boring default androgen that has no interesting properties apart
from agonizing the androgen receptor, but this is not true. Testosterone does have some
unique properties that deviate it from being purely an androgen receptor agonist.
WISP-2 mRNA expression
Testosterone promotes muscle growth and fat loss by increasing WISP-2 mRNA
expression (likely due to its aromatization into estradiol), which regulates growth factors
like IGF-1 and TGF-β. WISP-2 enhances lean mass, reduces fat, and improves insulin


sensitivity
Insulin sensitivity
Testosterone increases insulin sensitivity primarily through its metabolism into estradiol
and DHT. It decreases glucocorticoids (cortisol) in the liver through 5a-reductase, which
decreases catabolism and increases insulin sensitivity. It also greatly increases glucose
metabolism through its aromatization into estradiol and subsequ ent agonism of ER-a


A Verified Halhal