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The Science of Sebum
Disclaimer
Just talk to your dermatologist.

What is Sebum?
Sebum, in short, is what makes our skin oily. When someone has 'oily' skin type, it means they have a lot of sebum. It's 'produced' by the sebaceous glands and it does actually have a function in maintaining the health of the skin. It exists more than just to piss you off every morning. It's primarily composed of triglycerides (about 41%), wax esters (about 26%), squalene (about 12%), and fatty acids (about 16%).

Hair_follicle-en.jpg
The sebaceous glands sits right in the dermis (the middle layer of the skin). These glands are across the entire body, with the exception of the palms of your hands and the soles of your feet, with the highest density being found on the face, scalp, and upper chest. You will most likely find them with hair follicles. Sebocytes is the name of the process of sebum production.

In a foul attempt to visually describe what's happening here, essentially the gland's duct opens in the follicle canal, allowing sebum to be secreted along the hair shaft and onto the skin's surface. Okay, well, I guess I didn't need to describe it like that, but you get the point.

Technically not all sebaceous glands have to be near hair follicles, it's just where they're normally found. There's some named 'termed free sebaceous glands', which are the 'hair free' glands. Meibomian glands on your eyelids, Tyson glands on your peenis, and Fordyce spots to name a few examples. These 'termed free sebaceous glands' just kind of... ooze out onto your skin, I guess.

Now let's talk about the actual process of sebocytes. It starts as basic cells at the edge of the gland and as they 'grow' and 'change' (differentiate), they move towards the center of the gland and get bigger, filling up with fat droplets (lipids). This is mainly determined by the cells genes, but hormones, especially androgens like DHT, and insulin, IGF-1, and hydrocortisone, are also a factor in telling these cells to make fat droplets and to grow and whatnot. Then they just fucking die and explode. Yeah. Once they die, they explode (well, not really, but whatever) and that sebum ooze just travels up the hair shaft and out onto the skin, or just oozes out of the skin if there's no hair follicle. Because this process involves cell death, the gland constantly makes new skin cells at the bottom to replace them.

Sebum production changes a lot as we go through life. Even before we're born, our skin makes a waxy coating called vernix thanks to hormones from our mothers and ourselves. It's kind of the 'slime' that's on us when we're born. Right after birth, we make a lot of sebum for about a week. Then, it goes way down until we're around 9 or 10 years old. When puberty hits, sebum production shoots up again because of more hormones like testosterone. As adults, men tend to make a bit more sebum than women. But as we get older, especially after menopause for women, sebum production usually goes down.

Why Am I Producing So Much Sebum?
Earlier we talked about how hormones and genetics play a role in sebum production. This is true. However, dietary choices, environmental and stress may be factors too.

Foods that quickly raise our blood sugar, like white bread, sugary drinks, and processed snacks (look up the glycemic index if you want to learn more about this), in theory can cause inflammation in the body and lead to more oil production. Eating a lot of 'bad' fats, like saturated and omega-6 fats found in fast food and processed items, might also increase inflammation and oil production. On the other hand, 'good' fats like omega-3s found in fatty fish, nuts, and seeds might help control oil production and reduce skin inflammation. Certain vitamins and minerals, like vitamin A and zinc, are important for healthy skin and might help regulate oil. I know what you're probably thinking about this ground breaking science - "Wait, are you telling me that my diet also effects my appearance? Fuck. I hate this looksmaxxing shit." I totally get it. There's a reason why I kept saying 'may' and 'might', though. If it helps makes you feel better, it seems that diet alone might not make a huge difference in oil production. I know I'm going to be lynched in town square for saying that on here, but it's just what the current science implies. Make of that what you will.

Let's talk about factor number 2, environmental. What do I mean by that? Well, I mainly mean temperature, humidity, air pollution and... another thing I'm sure I'm going to get lynched for... sun exposure. When it's hot and humid, our skin tends to produce more oil, which can sometimes lead to more acne breakouts. Studies show that as the temperature goes up, so does oil production. On the other hand, when it's cold and dry, our skin might make less oil. Things like dust and pollution in the air can land on our skin and possibly clog our pores. This, in theory at least, can cause stress and swelling in the skin which causes more oil production. In regards of the sun exposure, if you've been reading my posts up until now, you'll probably have a rough idea where this is going. SUN = BAD FOR SKIN. Being in the sun can also make our skin produce more oil as a way to protect itself. The sun's UVB rays can also cause more inflammation in the cells that make oil. One of the components of sebum can even get damaged by the sun and might contribute to clogged pores. I'm sure you're starting to notice a pattern.

And finally, stress. This one is actually the easiest to explain. Stress can trigger the release of cortisol (the stress hormone), a hormone that has been shown to increase sebum production and potentially worsen acne.

Why Does This Matter?
Well, first let's go over why an over production of sebum can be bad to help you understand how to properly address it. Obviously, nobody likes the feeling of their skin being oily, right? That's issue number 1. Nobody likes acne either, so that's issue number 2. Nobody likes large or clogged pores too, I imagine, so that'd be issue number 3.

In regards of issue 1, which is oily skin. It can create a greasy or shiny appearance, particularly on the face, especially in the T-zone area (forehead, nose, and chin). This is more of an aesthetic issue, but obviously the more oily your skin is, it can lead to issue 2 and 3.

Acne is actually an inflammatory skin disorder of sorts, affecting the pilosebaceous unit (the hair follicle + sebaceous gland) and is strongly linked to increased
1744833643954.png
sebum production, a condition known as seborrhea. The delicious sebum-rich environment within these clogged pores can promote the overgrowth of Cutibacterium acnes bacteria, which in turn leads to inflammation and the development of various types of acne, including papules, pustules, nodules, and cysts, collectively known as inflammatory acne. Cystic and nodular acne, carry a higher risk of causing permanent scarring. RIP. Hormonal fluctuations, especially increases in androgen levels, are a significant trigger for acne, primarily by stimulating the production of sebum. Y'know how it is.

Now onto issue 3 - large or clogged pores. The accumulation of excess sebum within the pores can cause them to stretch, leading to a noticeable differences in their size. Not all of your large pores are caused by sebum production, but sebum production can cause large pores. Understand? When excess sebum and dead skin cells combine together, it can clog the hair follicles, leading to the formation of comedones, which just means clogged hair follicles and is commonly known as blackheads and whiteheads.

Sebum production can cause more issues than this, but let's be honest, you're here because you feel like you look ugly as fuck not because you're concerned about some medical condition. Talk to your doctor if you have any concerns.

What Do I Do now?
Cry. No, just kidding. Wash your face every day. That will normally help. Sometimes over washing can be an issue and can make sebum worse, so just don't overdo it. I would recommend a gentle and ideally oil-free facial cleanser. I normally suggest to people to do it in the morning and then before you head to bed. If you notice your skin is drying out, get a hydrating cleanser of some kind.

If you're looking for some skincare products (cleansers, exfoliants, toners, masks, spot treatments) in regards of sebum production, I normally only ever suggest a cleanser. In a majority of cases that's sincerely just the issue and in most cases doing more than that will make it worse. However, I thought I'd break down some ingredients a bit more for you guys here. If there's a ⭐ to it, it just means it's my personal preference and what I personally enjoy using.

Name
Short Description
⭐ Beta Hydroxy Acids (Salicylic)Exfoliates inside pores, reduces sebum, anti-inflammatory, antibacterial.
⭐ Niacinamide (Vitamin B3)Regulates sebum production, strengthens skin barrier, anti-inflammatory.
⭐ RetinoidsNormalizes skin cell turnover, regulates sebum production, anti-inflammatory, can prevent clogged pores.
Benzoyl PeroxideAntibacterial, helps remove excess oil, comedolytic.
Azelaic AcidPrevents clogged pores, antibacterial, anti-inflammatory, may inhibit 5α-reductase.
ZincRegulates sebum production, anti-inflammatory.
Green Tea ExtractTheoretically regulate sebum production, anti-inflammatory, antioxidant.
ClayAbsorbs excess sebum and impurities.
SqualeneMimics skin's natural oils, antioxidant.
ResveratrolAnti-inflammatory, antioxidant.
Soybean (Oil, proteins)Astringent, may regulate sebum production.
Sodium Ascorbyl PhosSkin lightener, may reduce pore appearance.
ChamomileAstringent, anti-inflammatory.
Licorice ExtractAnti-inflammatory, may control sebum production, brightens skin.

In other cases, prescription medicine is your best bet. If you have health insurance or are willing to pay out of pocket, I suggest seeing a dermatologist. They can prescribe you medicine and they can actually examine your face in more detail that your blurry camera and image compression upon uploading to a looksmaxxing forum just won't compare to. Most medicine will come in oral or topical form.

Name
Short Description
TretinoinTopical retinoid, normalize skin cell turnover, reduce sebum production, anti-inflammatory, can prevent clogged pores.
AdapaleneTopical retinoid, normalize skin cell turnover, reduce sebum production, anti-inflammatory, can prevent clogged pores.
TazaroteneTopical retinoid, normalize skin cell turnover, reduce sebum production, anti-inflammatory, can prevent clogged pores.
TrifaroteneTopical retinoid, normalize skin cell turnover, reduce sebum production, anti-inflammatory, can prevent clogged pores.
ClindamycinTopical antibiotic, kill excess bacteria on the skin, anti-inflammatory.
ErythromycinTopical antibiotic, kill excess bacteria on the skin, anti-inflammatory.
ClascoteroneTopical androgen receptor inhibitor.
Azelaic acid (20%)Topical antiseptic, antibacterial, may help post-inflammatory hyperpigmentation.
Dapsone (Aczone)Topical antibiotic, kill excess bacteria on the skin, anti-inflammatory.
OtherAsk your dermatologist for another recommendation than what's listed above.

There's other treatments such as laser treatments (AviClear/Smoothbeam/Aerolase), microdermabrasion, and photodynamic therapy, but I don't know JACK SHIT about any of that and I'm not going to pretend that I do. When looking into other stuff, I found out botulinum toxin injections might help, but again, I ain't know shit about that either.
 
Last edited:
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I learned something new details about sebum production. I already knew this but I didn't know the details of it.

Combined oral contraceptive pills (aka birth control), which contain both estrogen and progestin, can often lead to a reduction in sebum production. This, I sorta understood previously, but I guess this is because the estrogen in these pills can help to suppress the activity of the sebaceous glands. Progestin-only birth control pills (or combined pills with certain types of progestin that have androgenic properties, I guess) might not have the same sebum-reducing effect and could potentially even increase sebum production in some.

Most of the research I was looking at was mainly referring to testosterone. Everything I was reading did briefly mention everything I've just stated above but it was always a footnote and I was like "yeah everyone understands hormones effects sebum production, I don't need to break down every single hormone" but I thought it was interesting the more I looked into it and may help our lady folk on here. But this may explain why that before menstruation, a drop in estrogen levels can lead to a relative increase in androgens, which can then can increase sebum production. So if you notice a sudden increase in oily skin and acne with a birth control change or before your menstrual cycle, that might be why.
 
what cleansers, moisturisers and sun protection products would you recommend? im still new to skincare I wanna make it as simple as possible
 
what cleansers, moisturisers and sun protection products would you recommend? im still new to skincare I wanna make it as simple as possible
Normally I would recommend a 'hydrating' cleanser (CeraVe makes a good one in my opinion) and that's it, alongside a sunscreen of some kind. People like to focus too much on adding as many products as they can, and it makes it where people spend a lot of money on a lot of products they struggle to keep up with.

If you used a product up and didn't like it, try something new. I recommend buying the small sample size or travel size bottles of stuff to try them out instead of the full sized products.

Any sunscreen you use will be extremely subjective. I have a list of 3 products but even this is so subjective. All skin products are subjective, but sunscreen I've noticed a lot of people struggle with with finding the right one.

 
Normally I would recommend a 'hydrating' cleanser (CeraVe makes a good one in my opinion) and that's it, alongside a sunscreen of some kind. People like to focus too much on adding as many products as they can, and it makes it where people spend a lot of money on a lot of products they struggle to keep up with.

If you used a product up and didn't like it, try something new. I recommend buying the small sample size or travel size bottles of stuff to try them out instead of the full sized products.

Any sunscreen you use will be extremely subjective. I have a list of 3 products but even this is so subjective. All skin products are subjective, but sunscreen I've noticed a lot of people struggle with with finding the right one.

alr preciate it bro, ill look more into it, I was thinking of getting on accutane and dutasteride as well.
I already bought oral minoxidil, propranolol and memantine (for inhib)
also can u check your pm
 
Yo random whats ur thoughts on micro needling and taz with injectable ghkcu
I'm not really educated on either. I understand the surface level science of micro-needling enough to be like "it probably works as intended" but most reasons you would use micro-needling, Accutane can also probably fix.
 
Yo random, ever since I started increasing my adapalene use and added in glycolic acid 7% my skin has been looking more clear and im slowly starting to glow, once I stop using my sisters skin care products , buy taz, a derma stamp and ghkcu im gonna have the most mogger skin on here
 
Ok kinda crazy idea but does anyone think that applying topical DHT blocker, like topical finasteride to the super oily blackhead areas like my nose and midface would work?
 
⭐ Alpha Hydroxy Acids (Salicylic/glycolic/lactic)Exfoliates inside pores, reduces sebum, anti-inflammatory, antibacterial.
Hey, hate to be the one to do this and im not sure if anyone corrected you in the comments but Salicylic acid is not a Alpha Hydroxy Acid (AHA's), its a Beta Hydroxy Acids (BHA's). Basically the difference between the two is that BHA's exfoliate inside the pores and is antibacterial, anti-inflammatory etc... and is recommened for acne due to this reason, whilst AHA's exfoliate only the top layer of dead skins cells and is recommended for dull uneven skin tone etc.. I hope this can provide some value.
 
Hey, hate to be the one to do this and im not sure if anyone corrected you in the comments but Salicylic acid is not a Alpha Hydroxy Acid (AHA's), its a Beta Hydroxy Acids (BHA's). Basically the difference between the two is that BHA's exfoliate inside the pores and is antibacterial, anti-inflammatory etc... and is recommened for acne due to this reason, whilst AHA's exfoliate only the top layer of dead skins cells and is recommended for dull uneven skin tone etc.. I hope this can provide some value.
You're 100% correct. I would rather the information be correct, so if you ever notice something wrong with what I wrote, don't ever feel bad for pointing it out. I updated the post.

I was re-reading the original document I made and I don't actually know how I got them confused like that, besides maybe when I was formatting the post I wasn't really thinking about it. I was trying to focus on the Salicylic acid, but AHA was the wrong category altogether, like you said. Surprised nobody pointed it out sooner.

I actually made a similar error in my GLP-1 thread where I confused pancreatic beta cells and pancreatic alpha cells together, but I actually ended up catching the error a few months afterwards, so I ended up updating it then. Not sure why I've done it twice now. :monkahmm:
 
The Science of Sebum
Disclaimer
Just talk to your dermatologist.

What is Sebum?
Sebum, in short, is what makes our skin oily. When someone has 'oily' skin type, it means they have a lot of sebum. It's 'produced' by the sebaceous glands and it does actually have a function in maintaining the health of the skin. It exists more than just to piss you off every morning. It's primarily composed of triglycerides (about 41%), wax esters (about 26%), squalene (about 12%), and fatty acids (about 16%).

View attachment 90419The sebaceous glands sits right in the dermis (the middle layer of the skin). These glands are across the entire body, with the exception of the palms of your hands and the soles of your feet, with the highest density being found on the face, scalp, and upper chest. You will most likely find them with hair follicles. Sebocytes is the name of the process of sebum production.

In a foul attempt to visually describe what's happening here, essentially the gland's duct opens in the follicle canal, allowing sebum to be secreted along the hair shaft and onto the skin's surface. Okay, well, I guess I didn't need to describe it like that, but you get the point.

Technically not all sebaceous glands have to be near hair follicles, it's just where they're normally found. There's some named 'termed free sebaceous glands', which are the 'hair free' glands. Meibomian glands on your eyelids, Tyson glands on your peenis, and Fordyce spots to name a few examples. These 'termed free sebaceous glands' just kind of... ooze out onto your skin, I guess.

Now let's talk about the actual process of sebocytes. It starts as basic cells at the edge of the gland and as they 'grow' and 'change' (differentiate), they move towards the center of the gland and get bigger, filling up with fat droplets (lipids). This is mainly determined by the cells genes, but hormones, especially androgens like DHT, and insulin, IGF-1, and hydrocortisone, are also a factor in telling these cells to make fat droplets and to grow and whatnot. Then they just fucking die and explode. Yeah. Once they die, they explode (well, not really, but whatever) and that sebum ooze just travels up the hair shaft and out onto the skin, or just oozes out of the skin if there's no hair follicle. Because this process involves cell death, the gland constantly makes new skin cells at the bottom to replace them.

Sebum production changes a lot as we go through life. Even before we're born, our skin makes a waxy coating called vernix thanks to hormones from our mothers and ourselves. It's kind of the 'slime' that's on us when we're born. Right after birth, we make a lot of sebum for about a week. Then, it goes way down until we're around 9 or 10 years old. When puberty hits, sebum production shoots up again because of more hormones like testosterone. As adults, men tend to make a bit more sebum than women. But as we get older, especially after menopause for women, sebum production usually goes down.

Why Am I Producing So Much Sebum?
Earlier we talked about how hormones and genetics play a role in sebum production. This is true. However, dietary choices, environmental and stress may be factors too.

Foods that quickly raise our blood sugar, like white bread, sugary drinks, and processed snacks (look up the glycemic index if you want to learn more about this), in theory can cause inflammation in the body and lead to more oil production. Eating a lot of 'bad' fats, like saturated and omega-6 fats found in fast food and processed items, might also increase inflammation and oil production. On the other hand, 'good' fats like omega-3s found in fatty fish, nuts, and seeds might help control oil production and reduce skin inflammation. Certain vitamins and minerals, like vitamin A and zinc, are important for healthy skin and might help regulate oil. I know what you're probably thinking about this ground breaking science - "Wait, are you telling me that my diet also effects my appearance? Fuck. I hate this looksmaxxing shit." I totally get it. There's a reason why I kept saying 'may' and 'might', though. If it helps makes you feel better, it seems that diet alone might not make a huge difference in oil production. I know I'm going to be lynched in town square for saying that on here, but it's just what the current science implies. Make of that what you will.

Let's talk about factor number 2, environmental. What do I mean by that? Well, I mainly mean temperature, humidity, air pollution and... another thing I'm sure I'm going to get lynched for... sun exposure. When it's hot and humid, our skin tends to produce more oil, which can sometimes lead to more acne breakouts. Studies show that as the temperature goes up, so does oil production. On the other hand, when it's cold and dry, our skin might make less oil. Things like dust and pollution in the air can land on our skin and possibly clog our pores. This, in theory at least, can cause stress and swelling in the skin which causes more oil production. In regards of the sun exposure, if you've been reading my posts up until now, you'll probably have a rough idea where this is going. SUN = BAD FOR SKIN. Being in the sun can also make our skin produce more oil as a way to protect itself. The sun's UVB rays can also cause more inflammation in the cells that make oil. One of the components of sebum can even get damaged by the sun and might contribute to clogged pores. I'm sure you're starting to notice a pattern.

And finally, stress. This one is actually the easiest to explain. Stress can trigger the release of cortisol (the stress hormone), a hormone that has been shown to increase sebum production and potentially worsen acne.

Why Does This Matter?
Well, first let's go over why an over production of sebum can be bad to help you understand how to properly address it. Obviously, nobody likes the feeling of their skin being oily, right? That's issue number 1. Nobody likes acne either, so that's issue number 2. Nobody likes large or clogged pores too, I imagine, so that'd be issue number 3.

In regards of issue 1, which is oily skin. It can create a greasy or shiny appearance, particularly on the face, especially in the T-zone area (forehead, nose, and chin). This is more of an aesthetic issue, but obviously the more oily your skin is, it can lead to issue 2 and 3.

Acne is actually an inflammatory skin disorder of sorts, affecting the pilosebaceous unit (the hair follicle + sebaceous gland) and is strongly linked to increasedView attachment 90449 sebum production, a condition known as seborrhea. The delicious sebum-rich environment within these clogged pores can promote the overgrowth of Cutibacterium acnes bacteria, which in turn leads to inflammation and the development of various types of acne, including papules, pustules, nodules, and cysts, collectively known as inflammatory acne. Cystic and nodular acne, carry a higher risk of causing permanent scarring. RIP. Hormonal fluctuations, especially increases in androgen levels, are a significant trigger for acne, primarily by stimulating the production of sebum. Y'know how it is.

Now onto issue 3 - large or clogged pores. The accumulation of excess sebum within the pores can cause them to stretch, leading to a noticeable differences in their size. Not all of your large pores are caused by sebum production, but sebum production can cause large pores. Understand? When excess sebum and dead skin cells combine together, it can clog the hair follicles, leading to the formation of comedones, which just means clogged hair follicles and is commonly known as blackheads and whiteheads.

Sebum production can cause more issues than this, but let's be honest, you're here because you feel like you look ugly as fuck not because you're concerned about some medical condition. Talk to your doctor if you have any concerns.

What Do I Do now?
Cry. No, just kidding. Wash your face every day. That will normally help. Sometimes over washing can be an issue and can make sebum worse, so just don't overdo it. I would recommend a gentle and ideally oil-free facial cleanser. I normally suggest to people to do it in the morning and then before you head to bed. If you notice your skin is drying out, get a hydrating cleanser of some kind.

If you're looking for some skincare products (cleansers, exfoliants, toners, masks, spot treatments) in regards of sebum production, I normally only ever suggest a cleanser. In a majority of cases that's sincerely just the issue and in most cases doing more than that will make it worse. However, I thought I'd break down some ingredients a bit more for you guys here. If there's a ⭐ to it, it just means it's my personal preference and what I personally enjoy using.

Name
Short Description
⭐ Beta Hydroxy Acids (Salicylic)Exfoliates inside pores, reduces sebum, anti-inflammatory, antibacterial.
⭐ Niacinamide (Vitamin B3)Regulates sebum production, strengthens skin barrier, anti-inflammatory.
⭐ RetinoidsNormalizes skin cell turnover, regulates sebum production, anti-inflammatory, can prevent clogged pores.
Benzoyl PeroxideAntibacterial, helps remove excess oil, comedolytic.
Azelaic AcidPrevents clogged pores, antibacterial, anti-inflammatory, may inhibit 5α-reductase.
ZincRegulates sebum production, anti-inflammatory.
Green Tea ExtractTheoretically regulate sebum production, anti-inflammatory, antioxidant.
ClayAbsorbs excess sebum and impurities.
SqualeneMimics skin's natural oils, antioxidant.
ResveratrolAnti-inflammatory, antioxidant.
Soybean (Oil, proteins)Astringent, may regulate sebum production.
Sodium Ascorbyl PhosSkin lightener, may reduce pore appearance.
ChamomileAstringent, anti-inflammatory.
Licorice ExtractAnti-inflammatory, may control sebum production, brightens skin.

In other cases, prescription medicine is your best bet. If you have health insurance or are willing to pay out of pocket, I suggest seeing a dermatologist. They can prescribe you medicine and they can actually examine your face in more detail that your blurry camera and image compression upon uploading to a looksmaxxing forum just won't compare to. Most medicine will come in oral or topical form.

Name
Short Description
TretinoinTopical retinoid, normalize skin cell turnover, reduce sebum production, anti-inflammatory, can prevent clogged pores.
AdapaleneTopical retinoid, normalize skin cell turnover, reduce sebum production, anti-inflammatory, can prevent clogged pores.
TazaroteneTopical retinoid, normalize skin cell turnover, reduce sebum production, anti-inflammatory, can prevent clogged pores.
TrifaroteneTopical retinoid, normalize skin cell turnover, reduce sebum production, anti-inflammatory, can prevent clogged pores.
ClindamycinTopical antibiotic, kill excess bacteria on the skin, anti-inflammatory.
ErythromycinTopical antibiotic, kill excess bacteria on the skin, anti-inflammatory.
ClascoteroneTopical androgen receptor inhibitor.
Azelaic acid (20%)Topical antiseptic, antibacterial, may help post-inflammatory hyperpigmentation.
Dapsone (Aczone)Topical antibiotic, kill excess bacteria on the skin, anti-inflammatory.
OtherAsk your dermatologist for another recommendation than what's listed above.

There's other treatments such as laser treatments (AviClear/Smoothbeam/Aerolase), microdermabrasion, and photodynamic therapy, but I don't know JACK SHIT about any of that and I'm not going to pretend that I do. When looking into other stuff, I found out botulinum toxin injections might help, but again, I ain't know shit about that either.
good thread genuinely good. I found anti dht stuff to be good at reducing sebum too
 
love the indepth analysis honestly.
 
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