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They deleted the thread 😭

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@TonyDr may I ask why my thread was deleted? Why are some users telling me in my pms that β€˜I may get banned’ all of this is quite puzzling indeed.
 
Transposon_55 said:
@TonyDr may I ask why my thread was deleted? Why are some users telling me in my pms that β€˜I may get banned’ all of this is quite puzzling indeed.
Click to expand...
Literally posted a person's face that they want private
 
Transposon_55 said:
@TonyDr may I ask why my thread was deleted? Why are some users telling me in my pms that β€˜I may get banned’ all of this is quite puzzling indeed.
Click to expand...
honestly its not rlly doxxing since @over0 posted her face herself here before but its still not a cool thing to do
 
Tumor said:
Literally posted a person's face that they want private
Click to expand...
As I’ve already said I fish on legal grounds - Bradford, United Kingdom. What the fuck is the problem with my job?
60cca08d-1753-4b46-a9df-f814535e5a66.jpeg
 
Archelaus said:
elaborate?
Click to expand...
ive seen you a couple of times yet i know nothing about you at all yet youve been voted as motm by some
and if you dont mind me asking, what threads have you posted which gave you that contributor badge?
 
Archelaus said:
Yeah, i thought she always had it public.
@over0 You look pretty why are people attacking u
Click to expand...
I think it is a psychological effect. People see a pretty woman and instantly start hating. Women wanna be like them so they hate and men cuz they will never talk with anyone that pretty. It’s pretty fucking sad if you ask me!
60cca08d-1753-4b46-a9df-f814535e5a66.jpeg
 
over0 said:
I did take the threads down tbf so it's kind of a grey area but still petty af to do over a rating
Click to expand...
You taking them down means nobody should use them
 
ThraxxGlo said:
ive seen you a couple of times yet i know nothing about you at all yet youve been voted as motm by some
and if you dont mind me asking, what threads have you posted which gave you that contributor badge?
Click to expand...
Well i barely post on the offtopic section which most people are at so yeah barely anyone knows me, and i have alot of threads but favorites are:



Archelaus

Info ALL YOU BASICALLY NEED TO KNOW ABOUT NUTRITION (GTFIH)

The main context in which macronutrients matter is for body composition (body fat, water weight, and muscularity), which involves weight training too, as that is a large determining factor of your muscularity.

We will dive into how these macronutrients actually affect weight training outcomes, hypertrophy, and weight loss.

------------------------------------------------------------------

The Three Primary Macronutrients

Proteins, carbohydrates, and fats each play very distinct roles, and the degree to which these macronutrients actually help hypertrophy is very situational...
  • Gold
  • Like
  • Wow

Archelaus

Guide BIGGEST LOOKSMAXXING THREAD OF ALL TIME IN ALL FORUMS, THE HOLY GRAIL (GTFIHHHHH)

Ultimate Skincare Actives Showdown: Tretinoin vs. GHK-Cu vs. Accutane vs. Vitamin C vs. Niacinamide for Collagen, Elastin & Skin Quality

Introduction
The quest for youthful, resilient skin has led to the development of powerful skincare actives that target collagen synthesis, elastin production, and overall skin quality. This comprehensive comparison examines five heavy hitters: tretinoin, GHK-Cu (copper peptides), Accutane (isotretinoin), vitamin C, and niacinamide - analyzing their mechanisms, efficacy, and ideal applications for skin rejuvenation.

Mechanisms of Action

-...
  • Gold
  • Like

Archelaus

Info UPGRADE YOUR KNOWLEDGE ABOUT HORMONES AND UNDERSTAND MORE ABOUT HOW YOUR BODY WORKS

Introduction

Testosterone (T), the primary endogenous sex hormone in men, is a bioidentical anabolic-androgenic steroid (AAS) essential for male physiology. Many people think of testosterone as the boring default androgen that has no interesting properties apart from agonizing the androgen receptor, but this is not true. Testosterone does have some unique properties that deviate it from being purely an androgen receptor agonist.


---

WISP-2 mRNA Expression

Testosterone promotes muscle growth and fat loss by increasing WISP-2 mRNA expression (likely due to its aromatization into...
  • Gold
  • Like

Archelaus

Info HOW TGF-ẞ AGONISTS WORK, THEIR INTERACTION WITH HDACI, AND THEIR POTENTIAL FOR TARGETED SKELETAL ENHANCEMENT

TGF-B's Role in Bone Growth

1. Mechanisms of Action

TGF-B signaling influences bone development through:

Stimulation of Mesenchymal Stem Cells (MSCs) β†’ Drives osteoblast and chondrocyte differentiation.

Enhancement of Extracellular Matrix (ECM) Deposition β†’ Boosts collagen, osteocalcin, and alkaline phosphatase activity.

Modulation of Growth Plate Chondrocytes β†’ Supports longitudinal bone growth before epiphyseal closure.



---

2. TGF-B vs. BMP Signaling

While BMPs primarily drive osteoblast differentiation, TGF-B has a broader regulatory role:

Early-stage osteogenesis (MSC...
  • Gold

Archelaus

Info Building Better Bones: PTH Analogs, HDAC Inhibitors, and Hormonal Synergies in Skeletal and Craniofacial Growth

PTH Analogs: Mechanism of Action​


PTH analogs are engineered to replicate the anabolic effects of endogenous PTH while minimizing undesirable catabolic effects. The two main FDA-approved analogs are:



1. Teriparatide (PTH 1-34)​


  • Structure: Recombinant fragment containing the first 34 amino acids of PTH (the active binding region).
    • Binds to PTH1 receptors on osteoblasts, activating cAMP/PKA and Wnt/Ξ²-catenin pathways.
    • Stimulates osteoblast proliferation and differentiation, increasing...
  • Gold
  • Wow


Archelaus

Info EXTENDING THE GROWTH WINDOW, HOW TO UTILIZE ESTROGEN, AROMATASE INHIBITION, AND NEW PATHWAYS FOR HEIGHT AND BONE DEVELOPMENT

The Role of Estrogen in Bone Growth and Epiphyseal Closure

Bone growth is regulated by a complex interplay of hormones, with estrogen playing a crucial role:

1. Growth Plate Fusion

Estrogen accelerates epiphyseal (growth plate) closure in both males and females

In males, testosterone is peripherally converted to estrogen via aromatase, which ultimately mediates growth plate closure

Studies on males with aromatase deficiency or estrogen resistance show delayed epiphyseal fusion, leading to continued linear growth into adulthood (e.g., cases of men growing beyond age 25)


2. Bone...
  • Gold
  • Like
  • Hmm

Archelaus

Guide THE ULTIMATE BONE GROWTH ENHANCEMENT PROTOCOL. INTEGRATING EPIGENETIC MODULATORS, ANABOLIC AGENTS, HORMONAL SYNERGY, AND PRECISION NUTRITION

this thread is for informational and educational purposes only and is not intended as medical advice , hormonal manipulations may lead to accelerated aging and other health complications . DYOR


1. HDAC Inhibitors (Vorinostat) - Epigenetic Bone Enhancement

Histone deacetylase (HDAC) inhibitors, such as vorinostat (SAHA), have shown promise in promoting osteoblast differentiation and bone formation.

Mechanism: HDAC inhibitors modify gene expression, increasing RUNX2 activity (a key transcription factor for osteoblast differentiation).

Research: Studies indicate that...
  • Gold
  • Like
 
over0 said:
He's not ltn but he was claiming htn when he's mtn max more realistically lmtn
Click to expand...
Over u said im hmtn like in the morning. Are u this bad at memory
 
Archelaus said:
Well i barely post on the offtopic section which most people are at so yeah barely anyone knows me, and i have alot of threads but favorites are:



Archelaus

Info ALL YOU BASICALLY NEED TO KNOW ABOUT NUTRITION (GTFIH)

The main context in which macronutrients matter is for body composition (body fat, water weight, and muscularity), which involves weight training too, as that is a large determining factor of your muscularity.

We will dive into how these macronutrients actually affect weight training outcomes, hypertrophy, and weight loss.

------------------------------------------------------------------

The Three Primary Macronutrients

Proteins, carbohydrates, and fats each play very distinct roles, and the degree to which these macronutrients actually help hypertrophy is very situational...
  • Gold
  • Like
  • Wow

Archelaus

Guide BIGGEST LOOKSMAXXING THREAD OF ALL TIME IN ALL FORUMS, THE HOLY GRAIL (GTFIHHHHH)

Ultimate Skincare Actives Showdown: Tretinoin vs. GHK-Cu vs. Accutane vs. Vitamin C vs. Niacinamide for Collagen, Elastin & Skin Quality

Introduction
The quest for youthful, resilient skin has led to the development of powerful skincare actives that target collagen synthesis, elastin production, and overall skin quality. This comprehensive comparison examines five heavy hitters: tretinoin, GHK-Cu (copper peptides), Accutane (isotretinoin), vitamin C, and niacinamide - analyzing their mechanisms, efficacy, and ideal applications for skin rejuvenation.

Mechanisms of Action

-...
  • Gold
  • Like

Archelaus

Info UPGRADE YOUR KNOWLEDGE ABOUT HORMONES AND UNDERSTAND MORE ABOUT HOW YOUR BODY WORKS

Introduction

Testosterone (T), the primary endogenous sex hormone in men, is a bioidentical anabolic-androgenic steroid (AAS) essential for male physiology. Many people think of testosterone as the boring default androgen that has no interesting properties apart from agonizing the androgen receptor, but this is not true. Testosterone does have some unique properties that deviate it from being purely an androgen receptor agonist.


---

WISP-2 mRNA Expression

Testosterone promotes muscle growth and fat loss by increasing WISP-2 mRNA expression (likely due to its aromatization into...
  • Gold
  • Like

Archelaus

Info HOW TGF-ẞ AGONISTS WORK, THEIR INTERACTION WITH HDACI, AND THEIR POTENTIAL FOR TARGETED SKELETAL ENHANCEMENT

TGF-B's Role in Bone Growth

1. Mechanisms of Action

TGF-B signaling influences bone development through:

Stimulation of Mesenchymal Stem Cells (MSCs) β†’ Drives osteoblast and chondrocyte differentiation.

Enhancement of Extracellular Matrix (ECM) Deposition β†’ Boosts collagen, osteocalcin, and alkaline phosphatase activity.

Modulation of Growth Plate Chondrocytes β†’ Supports longitudinal bone growth before epiphyseal closure.



---

2. TGF-B vs. BMP Signaling

While BMPs primarily drive osteoblast differentiation, TGF-B has a broader regulatory role:

Early-stage osteogenesis (MSC...
  • Gold

Archelaus

Info Building Better Bones: PTH Analogs, HDAC Inhibitors, and Hormonal Synergies in Skeletal and Craniofacial Growth

PTH Analogs: Mechanism of Action​


PTH analogs are engineered to replicate the anabolic effects of endogenous PTH while minimizing undesirable catabolic effects. The two main FDA-approved analogs are:



1. Teriparatide (PTH 1-34)​


  • Structure: Recombinant fragment containing the first 34 amino acids of PTH (the active binding region).
    • Binds to PTH1 receptors on osteoblasts, activating cAMP/PKA and Wnt/Ξ²-catenin pathways.
    • Stimulates osteoblast proliferation and differentiation, increasing...
  • Gold
  • Wow


Archelaus

Info EXTENDING THE GROWTH WINDOW, HOW TO UTILIZE ESTROGEN, AROMATASE INHIBITION, AND NEW PATHWAYS FOR HEIGHT AND BONE DEVELOPMENT

The Role of Estrogen in Bone Growth and Epiphyseal Closure

Bone growth is regulated by a complex interplay of hormones, with estrogen playing a crucial role:

1. Growth Plate Fusion

Estrogen accelerates epiphyseal (growth plate) closure in both males and females

In males, testosterone is peripherally converted to estrogen via aromatase, which ultimately mediates growth plate closure

Studies on males with aromatase deficiency or estrogen resistance show delayed epiphyseal fusion, leading to continued linear growth into adulthood (e.g., cases of men growing beyond age 25)


2. Bone...
  • Gold
  • Like
  • Hmm

Archelaus

Guide THE ULTIMATE BONE GROWTH ENHANCEMENT PROTOCOL. INTEGRATING EPIGENETIC MODULATORS, ANABOLIC AGENTS, HORMONAL SYNERGY, AND PRECISION NUTRITION

this thread is for informational and educational purposes only and is not intended as medical advice , hormonal manipulations may lead to accelerated aging and other health complications . DYOR


1. HDAC Inhibitors (Vorinostat) - Epigenetic Bone Enhancement

Histone deacetylase (HDAC) inhibitors, such as vorinostat (SAHA), have shown promise in promoting osteoblast differentiation and bone formation.

Mechanism: HDAC inhibitors modify gene expression, increasing RUNX2 activity (a key transcription factor for osteoblast differentiation).

Research: Studies indicate that...
  • Gold
  • Like
Click to expand...
will read

oh this is for women i didnt know, doesnt apply to me in the slightest
 
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