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Volufiline: Why it's Cope and What to Do Instead YOURS TRULY, GENIO
- Why am I making this? -
So many of you guys are still under the impression that it works, so I thought I'd share why it's most likely cope. I also added a few alternatives to it after debunking it, so don't worry (although you softmaxxers can't really do anything but wait JFL). I also wanted to add that if you have a structural recession (as in your bone is recessed), just get fillers or hardmax because soft tissue improvement won't make your infraorbitals look significantly better.
So many of you guys are still under the impression that it works, so I thought I'd share why it's most likely cope. I also added a few alternatives to it after debunking it, so don't worry (although you softmaxxers can't really do anything but wait JFL). I also wanted to add that if you have a structural recession (as in your bone is recessed), just get fillers or hardmax because soft tissue improvement won't make your infraorbitals look significantly better.
1. Intro
2. Volufiline is Cope
3. Softmaxxing
4. Non-Surgical Procedures
5. Surgical Procedures
2. Volufiline is Cope
3. Softmaxxing
4. Non-Surgical Procedures
5. Surgical Procedures
- Volufiline is Cope -
Okay, I'll start off by just saying that the one (of few) Volufiline paper used as evidence was published by its marketer (Sederma: Volufiline's patent-holder).
Here's the paper: VOLUFILINE™
Nice figures right? Let's take a look at the bottom of the study.
Oh wow! What's this? Sederma? The marketer of Volufiline published the study?! How can I trust this? You can't.
But let's say you do. The marketers couldn't lie, could they? Well here's why it's cope based off this paper either way.
For those of you who don't know; vitro means outside of the body while vivo means on/in the body.
In the vitro figure, it shows some pretty good numbers. Cell volume increases x22 with Volufiline. Very cool, right? Then you remember that they probably just drowned some cells in a little petri dish with a metric ton of Volufiline. This is completely different from how your skin, as it has to make it through layers of skin before it makes it to your fat, which would be much less than in vitro numbers. Vivo figures are the only valid proof.
Ok, what about vivo? Here's another question; do breasts not naturally change in size? A mere 2.2% (the mean) increase after 56 days cannot prove anything. Breasts fluctuate either bigger or smaller all the time whether it be due to weight changes, menstrual cycle, or many other different factors that could cause them to change size. Maybe if they chose a site that wasn't so unpredictable due to many other factors, you could take it seriously (ignoring the fact that it's done by marketers). They could've chose the undereye or lips, but let's choose the most unpredictable site, right?
By the way, I couldn't find any other studies BECAUSE THIS SHIT IS FUCKING COPE!!!
Okay, I'll start off by just saying that the one (of few) Volufiline paper used as evidence was published by its marketer (Sederma: Volufiline's patent-holder).
Here's the paper: VOLUFILINE™
Nice figures right? Let's take a look at the bottom of the study.
Oh wow! What's this? Sederma? The marketer of Volufiline published the study?! How can I trust this? You can't.
But let's say you do. The marketers couldn't lie, could they? Well here's why it's cope based off this paper either way.
For those of you who don't know; vitro means outside of the body while vivo means on/in the body.
In the vitro figure, it shows some pretty good numbers. Cell volume increases x22 with Volufiline. Very cool, right? Then you remember that they probably just drowned some cells in a little petri dish with a metric ton of Volufiline. This is completely different from how your skin, as it has to make it through layers of skin before it makes it to your fat, which would be much less than in vitro numbers. Vivo figures are the only valid proof.
Ok, what about vivo? Here's another question; do breasts not naturally change in size? A mere 2.2% (the mean) increase after 56 days cannot prove anything. Breasts fluctuate either bigger or smaller all the time whether it be due to weight changes, menstrual cycle, or many other different factors that could cause them to change size. Maybe if they chose a site that wasn't so unpredictable due to many other factors, you could take it seriously (ignoring the fact that it's done by marketers). They could've chose the undereye or lips, but let's choose the most unpredictable site, right?
By the way, I couldn't find any other studies BECAUSE THIS SHIT IS FUCKING COPE!!!
- Softmaxxing -
So, how do I create new fat where I need it topically? PPARy activation, of course. How does PPARy agonism work? In simple terms, it pushes precursor cells (mesenchymal stem cells and preadipocytes) to mature into fat cells (adipocytes). So just apply a topical PPARy agonist, right? Easier said than done because there are currently NO topical PPARy agonists that I know of that are readily available on the market, but here's a study proving it can have some effect topically (with the limation that this was done on irradiated skin).
Topical Rosiglitazone Improves Fibrosis and Enhances Adipogenesis in Radiation-induced Skin Injury
Basically, this study uses topical rosiglitazone in vivo on rats with irradiated skin and ex vitro on human skin cells (again, vitro is not very good as evidence). They concluded that it can contribute to adipogenesis (formation of new fat cells), so I would say this is much more promising than Volufiline. There is the caveat that it's not available on the market though. You could (try to?) make it theoretically if you got your hands on some oral rosiglitazone, an organic solvent (DMSO, ethanol, hydro-alcoholic mixtures, etc.), a stable gel or cream (carbopol, carbomer), emulsifiers, preservatives, pH adjustments, and penetration enhancers. You'd also have to execute it perfectly, but I don't know any exact process of making it, so I'll leave it up to you guys if you can figure it out.
So, how do I create new fat where I need it topically? PPARy activation, of course. How does PPARy agonism work? In simple terms, it pushes precursor cells (mesenchymal stem cells and preadipocytes) to mature into fat cells (adipocytes). So just apply a topical PPARy agonist, right? Easier said than done because there are currently NO topical PPARy agonists that I know of that are readily available on the market, but here's a study proving it can have some effect topically (with the limation that this was done on irradiated skin).
Topical Rosiglitazone Improves Fibrosis and Enhances Adipogenesis in Radiation-induced Skin Injury
Basically, this study uses topical rosiglitazone in vivo on rats with irradiated skin and ex vitro on human skin cells (again, vitro is not very good as evidence). They concluded that it can contribute to adipogenesis (formation of new fat cells), so I would say this is much more promising than Volufiline. There is the caveat that it's not available on the market though. You could (try to?) make it theoretically if you got your hands on some oral rosiglitazone, an organic solvent (DMSO, ethanol, hydro-alcoholic mixtures, etc.), a stable gel or cream (carbopol, carbomer), emulsifiers, preservatives, pH adjustments, and penetration enhancers. You'd also have to execute it perfectly, but I don't know any exact process of making it, so I'll leave it up to you guys if you can figure it out.
- Non-Surgical Procedures -
Fillers are basically your only option here. Here's a section altered from my Comprehensive EyeMaxxing Guide (For Men).
Fillers:
- Filler: An injection of hyaluronic acid to restore volume and provide structural support. Typically $700 to $1,500 per syringe and typically lasts up to a year depending on the type of filler. Note that filler dissolves over time and may result in an unnatural appearance. Make sure to get your filler dissolved before this happens.
- Under-eye Filler: An injection in the tear trough and under-eye hollow, just below the orbital. It provides under-eye support and helps with under-eye hollowing. It increases the orbital vector.
- Lip Filler: An injection in either the upper or lower lip (or both, duh). It increases lip volume and makes them fuller. (Not from my other guide)
DIY Fillers:
- Note: Do your own research on anatomy and figure out YOUR specific anatomy. I will only provide the specific locations and amounts you'll need for each DIY procedure. I will not give you an in-depth personalized explanation for each.
- Context: DO YOUR OWN RESEARCH AND DO NOT RELY SOLELY ON THIS THREAD. I'M MERELY HERE TO GIVE A BRIEF GUIDLINE. Besides filler (hyaluronic acid) itself, the first thing you'll need is hyaluronidase (which you need to reconstitute, look it up) to dissolve your filler if you mess up. I'd also heavily recommend some 4% to 5% lidocaine cream to numb the pain of injection. It makes the process much smoother and more bearable.
- How to Inject: Before you start injecting, ASPIRATING IS MANDATORY. It's when you leave the needle in the injection site for about 10-15 seconds and see if any blood starts bleeding into the needle. If it does, do not inject there. Keep going until you find spots without any leakage. It's not perfect risk management however, so do be aware you still might pin into an artery. If you do, IMMEDIATELY inject hyaluronidase and maybe call an ambulance. Otherwise, mark lines where you want to inject and understand your anatomy.
- Under-eye Filler: Infraorbital, 0.5mL-1.0mL total and 0.25mL–0.5mL per eye
- Lip Filler: Vermilion border/body of lips, 0.5mL–1.0mL total and 0.25mL–0.5mL per lip. (Not from my other guide)
Note that for the under-eyes, it provides structural support, not fatty tissue support, so keep that in mind (Although most infra issues are structural anyways).
Fillers are basically your only option here. Here's a section altered from my Comprehensive EyeMaxxing Guide (For Men).
Fillers:
- Filler: An injection of hyaluronic acid to restore volume and provide structural support. Typically $700 to $1,500 per syringe and typically lasts up to a year depending on the type of filler. Note that filler dissolves over time and may result in an unnatural appearance. Make sure to get your filler dissolved before this happens.
- Under-eye Filler: An injection in the tear trough and under-eye hollow, just below the orbital. It provides under-eye support and helps with under-eye hollowing. It increases the orbital vector.
- Lip Filler: An injection in either the upper or lower lip (or both, duh). It increases lip volume and makes them fuller. (Not from my other guide)
DIY Fillers:
- Note: Do your own research on anatomy and figure out YOUR specific anatomy. I will only provide the specific locations and amounts you'll need for each DIY procedure. I will not give you an in-depth personalized explanation for each.
- Context: DO YOUR OWN RESEARCH AND DO NOT RELY SOLELY ON THIS THREAD. I'M MERELY HERE TO GIVE A BRIEF GUIDLINE. Besides filler (hyaluronic acid) itself, the first thing you'll need is hyaluronidase (which you need to reconstitute, look it up) to dissolve your filler if you mess up. I'd also heavily recommend some 4% to 5% lidocaine cream to numb the pain of injection. It makes the process much smoother and more bearable.
- How to Inject: Before you start injecting, ASPIRATING IS MANDATORY. It's when you leave the needle in the injection site for about 10-15 seconds and see if any blood starts bleeding into the needle. If it does, do not inject there. Keep going until you find spots without any leakage. It's not perfect risk management however, so do be aware you still might pin into an artery. If you do, IMMEDIATELY inject hyaluronidase and maybe call an ambulance. Otherwise, mark lines where you want to inject and understand your anatomy.
- Under-eye Filler: Infraorbital, 0.5mL-1.0mL total and 0.25mL–0.5mL per eye
- Lip Filler: Vermilion border/body of lips, 0.5mL–1.0mL total and 0.25mL–0.5mL per lip. (Not from my other guide)
Note that for the under-eyes, it provides structural support, not fatty tissue support, so keep that in mind (Although most infra issues are structural anyways).
- Surgical Procedures -
Again, here's a section altered from my Comprehensive EyeMaxxing Guide (For Men).
Surgeries:
Fat Grafting: Takes fat from one part of the body and puts it elsewhere. This is a very versatile surgery and the one I would recommend most for under-eye issues. It could also work for the lips, but its less reliable than fillers and I wouldn't recommend it over fillers.
Orbital Rim Augmentation: Implants placed directly on the orbital rim. It adds volume to the orbital rim and makes the eyes look deeper-set and more structured. It helps with recessed infraorbital rims. It improves orbital vector and under-eye support.
Fat Graphing (DIY): @giga.mia boyos cuz i aint explaining this wizardry
You can use DIY fat graphing on the upper eyelid to get rid of upper eyelid exposure and on your under-eyes to add volume.
"This is when you transfer fat to another part of your body. This fat can be either autologous or exogenous, but autologous is the obvious best and safest way to go about it. During the duration of the procedure you undergo a liposuction, the fat is processed, and then reinjected into your desired location."
- brief summary by @giga.mia
Press here for part 1 of fat graphing -> Fat Harvesting
Press here for part 2 of fat graphing -> Fat Purification + Injection
Again, here's a section altered from my Comprehensive EyeMaxxing Guide (For Men).
Surgeries:
Fat Grafting: Takes fat from one part of the body and puts it elsewhere. This is a very versatile surgery and the one I would recommend most for under-eye issues. It could also work for the lips, but its less reliable than fillers and I wouldn't recommend it over fillers.
Orbital Rim Augmentation: Implants placed directly on the orbital rim. It adds volume to the orbital rim and makes the eyes look deeper-set and more structured. It helps with recessed infraorbital rims. It improves orbital vector and under-eye support.
Fat Graphing (DIY): @giga.mia boyos cuz i aint explaining this wizardry
You can use DIY fat graphing on the upper eyelid to get rid of upper eyelid exposure and on your under-eyes to add volume.
"This is when you transfer fat to another part of your body. This fat can be either autologous or exogenous, but autologous is the obvious best and safest way to go about it. During the duration of the procedure you undergo a liposuction, the fat is processed, and then reinjected into your desired location."
- brief summary by @giga.mia
Press here for part 1 of fat graphing -> Fat Harvesting
Press here for part 2 of fat graphing -> Fat Purification + Injection
inb4 dnr
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