Hypothesis why a lower dose of erdafitinib can still have an effect

[klyro]

i was looking into erdafitinib and the dose response is actually pretty interesting
the amount of erdafitinib in your blood obviously matters but the amount thats actually free matters too
AAG is one of the main proteins that binds to erdafitinib. since most of the drug is protein bound the amount of free drug can change depending on AAG levels and other factors
this is interesting because cancer patients can have higher AAG levels than healthy people. one study found the mean free fraction was around 0.51% in healthy people compared to 0.32% in cancer patients
so you cant just look at pharmacokinetic data from cancer patients and assume its gonna work exactly the same in a healthy person
the other thing i found interesting was the relationship between drug exposure and inhibition
i originally thought more drug = proportionally more inhibition but thats not necessarily how dose response works
basically
more drug = more exposure
but
more exposure doesnt always = the same increase in effect
a dose response curve can start flattening when you get closer to the upper end of the response
so doubling the exposure doesnt automatically mean youre gonna double the biological effect
also the specific numbers from theoretical calculations shouldnt be treated like actual human FGFR3 inhibition data. erdafitinib is a cancer drug and the clinical pharmacology data show dose proportional exposure across the studied 0.5–12 mg range
the main thing i found interesting is how much protein binding can affect the amount of free drug and how dose response isnt always as simple as looking at the mg

Spoiler: sources

https://pubmed.ncbi.nlm.nih.gov/31602692/
https://pubmed.ncbi.nlm.nih.gov/31742712/
https://pubmed.ncbi.nlm.nih.gov/34755484/
https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=2a8aa5c0-6c92-4566-8c45-e8f4d1fc20ee

@Dearpleasehelpme what do u think abt it baby ive been working on it since I told u abt it in vc

 

[klyro]

bump, I wont mass tag yet cuz idk if its good

 

[klyro]

 

[klyro]

 

[klyro]

fuck you n*****s im mass tagging

 

[klyro]

Spoiler: mass tag cuz I got ignored

@northka @xorsizm @Nobodyreallycares @Luffy @Splankу @Hypertrophy @copevictim @Ghoultune @meh.guy @whore @yyoloo @klyro @doe.eyed_deer11 @ImNotSorry @rxpeangelz @sodium @iletheile @DEAN 2.0 @Noah Olivier Smith @widepalate @Ascending Machine @saint @sub3 chud @Recai @tomokoisliterallyme @gatetoheaven @darkerthangrey @tension @gaylien @animenerd123 @Neurodivergentt @thistimeiwontquit@10 @cutelittledaisyflower @OYASUMIAZI @ascendingthisyear @foidslayer @SevenColorCrystalBall @kora @Onyxae @1baar @emocel @derpy @JackthehammerJack @Rased @2400_nomie @Beani @benny @Angel @johnarcabob_reincarnated @Spongebob CirclePants @elvs @madma @melanotanjunky @chels_slayer @The Centipede @Dancin @Haurucky @BradyT @arniedagoats @Br4va @ankit13 @thanos5 @clark kent @Buff_miner77 @trueswan @submissivechud @Kalki.unbound.mindset @Byro @Forsaken Destiny @genio @iluvbunnys @Paradise @xoxo @Doe_eyes @lotuus @BigDihDiddy ⚦ @wutdamooo @Kitsune @PingPong @yielded @fallout @gimp @Eren Yeager's disciple @dontcallthemfoidsbro @JDD8 @vespertine @übermenschgrimreaper @ermhilol @leocopes @adelotes @Evilthinker21 @moonlight1 @windtl @True king of LTNs @zennn @#sensitiveyoungwoman @505 @Uniquelysub3 @virgile @LaWi @ethnicbull @XWJJ @leocopes @Oxytocin? @nzxt @rrtzx @vasilica @BasedMidTierNormie @anabol1c @junebug @Aryy @ivarask @eqw @Zygos @CraigtheCrow @aesthetixx @kora @theduff @broccoli @TheEthnicGod @Big Biceps @betterthananyonelolxx @vxvqv @Shitovoy @Seraphiel @DonJuanDeMarco @Siahhh @CesarZet @Danielson5523 @Xiomai(mttkze19) @hopefuel @arow @Testicular @wannabelonewolf @viasco @TFC @kittycorn3 @Remorse @Lovinglad @misclick @khhvcel @idkwhoitis @Judge Holden @IncelistFoidSoulReaper @Cinnamon fan64 @Penalizer69 @giga.mia @Goat Saint @cinnamonchick22 @Orka reply to be tagged in future posts.

 

[whore]

Spoiler: mass tag cuz I got ignored

@northka @xorsizm @Nobodyreallycares @Luffy @Splankу @Hypertrophy @copevictim @Ghoultune @meh.guy @whore @yyoloo @klyro @doe.eyed_deer11 @ImNotSorry @rxpeangelz @sodium @iletheile @DEAN 2.0 @Noah Olivier Smith @widepalate @Ascending Machine @saint @sub3 chud @Recai @tomokoisliterallyme @gatetoheaven @darkerthangrey @tension @gaylien @animenerd123 @Neurodivergentt @thistimeiwontquit@10 @cutelittledaisyflower @OYASUMIAZI @ascendingthisyear @foidslayer @SevenColorCrystalBall @kora @Onyxae @1baar @emocel @derpy @JackthehammerJack @Rased @2400_nomie @Beani @benny @Angel @johnarcabob_reincarnated @Spongebob CirclePants @elvs @madma @melanotanjunky @chels_slayer @The Centipede @Dancin @Haurucky @BradyT @arniedagoats @Br4va @ankit13 @thanos5 @clark kent @Buff_miner77 @trueswan @submissivechud @Kalki.unbound.mindset @Byro @Forsaken Destiny @genio @iluvbunnys @Paradise @xoxo @Doe_eyes @lotuus @BigDihDiddy ⚦ @wutdamooo @Kitsune @PingPong @yielded @fallout @gimp @Eren Yeager's disciple @dontcallthemfoidsbro @JDD8 @vespertine @übermenschgrimreaper @ermhilol @leocopes @adelotes @Evilthinker21 @moonlight1 @windtl @True king of LTNs @zennn @#sensitiveyoungwoman @505 @Uniquelysub3 @virgile @LaWi @ethnicbull @XWJJ @leocopes @Oxytocin? @nzxt @rrtzx @vasilica @BasedMidTierNormie @anabol1c @junebug @Aryy @ivarask @eqw @Zygos @CraigtheCrow @aesthetixx @kora @theduff @broccoli @TheEthnicGod @Big Biceps @betterthananyonelolxx @vxvqv @Shitovoy @Seraphiel @DonJuanDeMarco @Siahhh @CesarZet @Danielson5523 @Xiomai(mttkze19) @hopefuel @arow @Testicular @wannabelonewolf @viasco @TFC @kittycorn3 @Remorse @Lovinglad @misclick @khhvcel @idkwhoitis @Judge Holden @IncelistFoidSoulReaper @Cinnamon fan64 @Penalizer69 @giga.mia @Goat Saint @cinnamonchick22 @Orka reply to be tagged in future posts.

n***a tagging me AFTER my erda guide

 

[klyro]

n***a tagging me AFTER my erda guide

yeah n****r this supports ur fucking guide

 

[klyro]

n***a tagging me AFTER my erda guide

now be a good fucking goy and rep this fucking shit n****r

 

[klyro]

I didnt waste 6+ hours of my life for 2 reps

 

[whore]

yeah n****r this supports ur fucking guide

now be a good fucking goy and rep this fucking shit n****r

this is why epistein doodled with your fucking rectum

 

[Cinnamon fan64]

did read, interesting

 

[whore]

episten fucking ruined youe rectum the way the shit coming out of your mouth rather than ass

 

[klyro]

did read, interesting

ty cinnamon fan64

 

[khhvcel]

i was looking into erdafitinib and the dose response is actually pretty interesting
the amount of erdafitinib in your blood obviously matters but the amount thats actually free matters too
AAG is one of the main proteins that binds to erdafitinib. since most of the drug is protein bound the amount of free drug can change depending on AAG levels and other factors
this is interesting because cancer patients can have higher AAG levels than healthy people. one study found the mean free fraction was around 0.51% in healthy people compared to 0.32% in cancer patients
so you cant just look at pharmacokinetic data from cancer patients and assume its gonna work exactly the same in a healthy person
the other thing i found interesting was the relationship between drug exposure and inhibition
i originally thought more drug = proportionally more inhibition but thats not necessarily how dose response works
basically
more drug = more exposure
but
more exposure doesnt always = the same increase in effect
a dose response curve can start flattening when you get closer to the upper end of the response
so doubling the exposure doesnt automatically mean youre gonna double the biological effect
also the specific numbers from theoretical calculations shouldnt be treated like actual human FGFR3 inhibition data. erdafitinib is a cancer drug and the clinical pharmacology data show dose proportional exposure across the studied 0.5–12 mg range
the main thing i found interesting is how much protein binding can affect the amount of free drug and how dose response isnt always as simple as looking at the mg

Spoiler: sources

https://pubmed.ncbi.nlm.nih.gov/31602692/
https://pubmed.ncbi.nlm.nih.gov/31742712/
https://pubmed.ncbi.nlm.nih.gov/34755484/
https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=2a8aa5c0-6c92-4566-8c45-e8f4d1fc20ee

@Dearpleasehelpme what do u think abt it baby ive been working on it since I told u abt it in vc

bump

 

[klyro]

episten fucking ruined youe rectum the way the shit coming out of your mouth rather than ass

stop telling me ur fantasies n****r

 

[Cinnamon fan64]

ty cinnamon fan64

ur wellcum

 

[klyro]

ur wellcum

 

[tension]

every heightmaxxing drug is useless unless started before ur like 13 which is obv not happening

only real heightmaxxes are lifts and LL

 

[Dearpleasehelpme]

i was looking into erdafitinib and the dose response is actually pretty interesting
the amount of erdafitinib in your blood obviously matters but the amount thats actually free matters too
AAG is one of the main proteins that binds to erdafitinib. since most of the drug is protein bound the amount of free drug can change depending on AAG levels and other factors
this is interesting because cancer patients can have higher AAG levels than healthy people. one study found the mean free fraction was around 0.51% in healthy people compared to 0.32% in cancer patients
so you cant just look at pharmacokinetic data from cancer patients and assume its gonna work exactly the same in a healthy person
the other thing i found interesting was the relationship between drug exposure and inhibition
i originally thought more drug = proportionally more inhibition but thats not necessarily how dose response works
basically
more drug = more exposure
but
more exposure doesnt always = the same increase in effect
a dose response curve can start flattening when you get closer to the upper end of the response
so doubling the exposure doesnt automatically mean youre gonna double the biological effect
also the specific numbers from theoretical calculations shouldnt be treated like actual human FGFR3 inhibition data. erdafitinib is a cancer drug and the clinical pharmacology data show dose proportional exposure across the studied 0.5–12 mg range
the main thing i found interesting is how much protein binding can affect the amount of free drug and how dose response isnt always as simple as looking at the mg

Spoiler: sources

https://pubmed.ncbi.nlm.nih.gov/31602692/
https://pubmed.ncbi.nlm.nih.gov/31742712/
https://pubmed.ncbi.nlm.nih.gov/34755484/
https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=2a8aa5c0-6c92-4566-8c45-e8f4d1fc20ee

@Dearpleasehelpme what do u think abt it baby ive been working on it since I told u abt it in vc

W effort post bhai ily

 

[klyro]

W effort post bhai ily

ilyt

 

[Say yes to heaven]

I didn't waste 6+ hours of my life for 2 reps

ngl bro, you could've googled it, tbh

High AAG protein levels in cancer patients bind up more erdafitinib, leaving less unbound drug active in the blood compared to healthy individuals. Furthermore, drug response follows a curve that flattens near maximum receptor saturation, meaning higher exposure yields diminishing biological returns once targets are saturated.

Also, the Emax model is nearly universal in pharmacology; you could have guessed this
It is one of the most fundamental principles governing how drugs work. btw

 

[Dearpleasehelpme]

I didnt waste 6+ hours of my life for 2 reps

Everyone asleep rn I think

 

[klyro]

ngl bro, you could've googled it, tbh

Also, the Emax model is nearly universal in pharmacology; you could have guessed this
It is one of the most fundamental principles governing how drugs work. btw

yo n****r I made it in 1hour and 30 mins I just wanted it to have a dramatic effect

 

[sodium]

Tag me more

 

[Big Biceps]

Just do 1 mg

 

[Mandy?]

Wootah

 

[klyro]

Wootah

Wootah

 

[animenerd123]

Spoiler: mass tag cuz I got ignored

@northka @xorsizm @Nobodyreallycares @Luffy @Splankу @Hypertrophy @copevictim @Ghoultune @meh.guy @whore @yyoloo @klyro @doe.eyed_deer11 @ImNotSorry @rxpeangelz @sodium @iletheile @DEAN 2.0 @Noah Olivier Smith @widepalate @Ascending Machine @saint @sub3 chud @Recai @tomokoisliterallyme @gatetoheaven @darkerthangrey @tension @gaylien @animenerd123 @Neurodivergentt @thistimeiwontquit@10 @cutelittledaisyflower @OYASUMIAZI @ascendingthisyear @foidslayer @SevenColorCrystalBall @kora @Onyxae @1baar @emocel @derpy @JackthehammerJack @Rased @2400_nomie @Beani @benny @Angel @johnarcabob_reincarnated @Spongebob CirclePants @elvs @madma @melanotanjunky @chels_slayer @The Centipede @Dancin @Haurucky @BradyT @arniedagoats @Br4va @ankit13 @thanos5 @clark kent @Buff_miner77 @trueswan @submissivechud @Kalki.unbound.mindset @Byro @Forsaken Destiny @genio @iluvbunnys @Paradise @xoxo @Doe_eyes @lotuus @BigDihDiddy ⚦ @wutdamooo @Kitsune @PingPong @yielded @fallout @gimp @Eren Yeager's disciple @dontcallthemfoidsbro @JDD8 @vespertine @übermenschgrimreaper @ermhilol @leocopes @adelotes @Evilthinker21 @moonlight1 @windtl @True king of LTNs @zennn @#sensitiveyoungwoman @505 @Uniquelysub3 @virgile @LaWi @ethnicbull @XWJJ @leocopes @Oxytocin? @nzxt @rrtzx @vasilica @BasedMidTierNormie @anabol1c @junebug @Aryy @ivarask @eqw @Zygos @CraigtheCrow @aesthetixx @kora @theduff @broccoli @TheEthnicGod @Big Biceps @betterthananyonelolxx @vxvqv @Shitovoy @Seraphiel @DonJuanDeMarco @Siahhh @CesarZet @Danielson5523 @Xiomai(mttkze19) @hopefuel @arow @Testicular @wannabelonewolf @viasco @TFC @kittycorn3 @Remorse @Lovinglad @misclick @khhvcel @idkwhoitis @Judge Holden @IncelistFoidSoulReaper @Cinnamon fan64 @Penalizer69 @giga.mia @Goat Saint @cinnamonchick22 @Orka reply to be tagged in future posts.

Don't @ me n***a

 

[arniedagoats]

.

 

[klyro]

Don't @ me n***a

Sorry sorry

 

[klyro]

Should i make a guide again or do yall not love me any more?

 

[Say yes to heaven]

Should i make a guide again or do yall not love me any more?

You are beloved by this community, dw

 

[klyro]

@Nobodyreallycares

 

[klyro]

bump

 

[🌑Rhasta-Fara🌑]

i was looking into erdafitinib and the dose response is actually pretty interesting
the amount of erdafitinib in your blood obviously matters but the amount thats actually free matters too
AAG is one of the main proteins that binds to erdafitinib. since most of the drug is protein bound the amount of free drug can change depending on AAG levels and other factors
this is interesting because cancer patients can have higher AAG levels than healthy people. one study found the mean free fraction was around 0.51% in healthy people compared to 0.32% in cancer patients
so you cant just look at pharmacokinetic data from cancer patients and assume its gonna work exactly the same in a healthy person
the other thing i found interesting was the relationship between drug exposure and inhibition
i originally thought more drug = proportionally more inhibition but thats not necessarily how dose response works
basically
more drug = more exposure
but
more exposure doesnt always = the same increase in effect
a dose response curve can start flattening when you get closer to the upper end of the response
so doubling the exposure doesnt automatically mean youre gonna double the biological effect
also the specific numbers from theoretical calculations shouldnt be treated like actual human FGFR3 inhibition data. erdafitinib is a cancer drug and the clinical pharmacology data show dose proportional exposure across the studied 0.5–12 mg range
the main thing i found interesting is how much protein binding can affect the amount of free drug and how dose response isnt always as simple as looking at the mg

Spoiler: sources

https://pubmed.ncbi.nlm.nih.gov/31602692/
https://pubmed.ncbi.nlm.nih.gov/31742712/
https://pubmed.ncbi.nlm.nih.gov/34755484/
https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=2a8aa5c0-6c92-4566-8c45-e8f4d1fc20ee

@Dearpleasehelpme what do u think abt it baby ive been working on it since I told u abt it in vc

why do you know all this?

 

[klyro]

why do you know all this?

Whats wrong with me knowing shit

 

[🌑Rhasta-Fara🌑]

Whats wrong with me knowing shit

not u knowing shit in general but someone who doesn't major or graduate college for a topic like this- its kinda concerning

 

[klyro]

not u knowing shit in general but someone who doesn't major or graduate college for a topic like this- its kinda concerning

How is it concerming bhai

 

[klyro]

Btw @Dearpleasehelpme bump this thread a bit more i want to add pictures that i forgot to add

 

[Dearpleasehelpme]

Btw @Dearpleasehelpme bump this thread a bit more i want to add pictures that i forgot to add

Alr