Guide Why glycolysis will always have better ATP outcomes than fat oxidation (Must Read)

[Kaligula567]

Enough jestering and making water threads, yeye me and @Mandy? lowkey making this one for the niche niqqas here, full of top g info fr, thank my niqqa mandy for providing me with the niche info needed

First we will look deeply into the starting point where glucose utilization completely obliterates fat oxidation, ATP/O2 PR rate.
First of all, what exactly is the ATP/O2 PR rate? In short,it’s the rate of how much ATP you can generate with the rate of oxygen. The PO ratio (phosphate to oxygen) greatly determines this.

PO ratio of different ATP generation sources:

Glucose oxidation: 2.58-2.7 ATP per oxygen atom
Fat oxidation (palmitate): 2.33 ATP per oxygen atom
And what does this exactly prove? Mitochondria can more efficiently generate ATP using the same amount of oxygen with glucose than fat oxidation.

Benefits?

-Faster ATP generation
-increased CO2 production
-higher ATP throughput
-lower stress hormones
-lower ROS
-Activation of PDH

Low carb retards like to argue that fat oxidation of palmitate yields 3x more ATP than glucose,this is true with no denial. But generally this argument is useless due to what I’ve stated before on ATP/O2 PR rate and here’s why!

General ATP generation from different energy sources:

Glucose oxidation: ~32 ATP
Fat oxidation (palmitate):106 ATP

And that’s a huge difference,but why is this useless?

ATP demand isn’t heavily depended and based by the amount of molecules and general ATP is limited by enzyme and oxygen availability. Due to the better P/O ratio of glucose,glucose can be used more efficiently with the same oxygen amount than fatty acids. This leads to faster and more rapid ATP turnover which is ideal for tissues requiring fast energy. In terms of this,speed>quantity


Things that make fat oxidation worse is its increase in ROS. What this leads to:

-Increased superoxide (can metabolize into harmful compounds if levels are higher)

-More oxidative stress (more oxygen needed for ATP generation)

-A higher amount of prelipid oxidation


Glucose in comparison,is a way cleaner energy source for your cells.

This was it,I hope I don’t only get 2 reps for this since this is in my opinion the most High IQ thread I’ve made so far. Hopefully all low carb nigs will bow down to Ray Peat.


@Dean @Spuffy @Love @Phosphophilyte

 

[UseAdHomines]

keys

 

[Kaligula567]

keys

Incel user

 

[UseAdHomines]

Incel user

correct but dislike

 

[Kaligula567]

Lowkey I need to tag some nikkas noone online except this greyfag

@MogsGymMaxx @ecoli @Alurmo @GoryToad @+Enrique+

 

[Kaligula567]

correct but dislike

Why?

 

[MogsGymMaxx]

Those who bump

 

[Sherlock]

Enough jestering and making water threads, yeye me and @Mandy? lowkey making this one for the niche niqqas here, full of top g info fr, thank my niqqa mandy for providing me with the niche info needed

View attachment 245607

First we will look deeply into the starting point where glucose utilization completely obliterates fat oxidation, ATP/O2 PR rate.
First of all, what exactly is the ATP/O2 PR rate? In short,it’s the rate of how much ATP you can generate with the rate of oxygen. The PO ratio (phosphate to oxygen) greatly determines this.
PO ratio of different ATP generation sources:

Glucose oxidation: 2.58-2.7 ATP per oxygen atom
Fat oxidation (palmitate): 2.33 ATP per oxygen atom
And what does this exactly prove? Mitochondria can more efficiently generate ATP using the same amount of oxygen with glucose than fat oxidation.

Benefits?
-Faster ATP generation
-increased CO2 production
-higher ATP throughput
-lower stress hormones
-lower ROS
-Activation of PDH

Low carb retards like to argue that fat oxidation of palmitate yields 3x more ATP than glucose,this is true with no denial. But generally this argument is useless due to what I’ve stated before on ATP/O2 PR rate and here’s why!

General ATP generation from different energy sources:

Glucose oxidation: ~32 ATP
Fat oxidation (palmitate):106 ATP

And that’s a huge difference,but why is this useless?

ATP demand isn’t heavily depended and based by the amount of molecules and general ATP is limited by enzyme and oxygen availability. Due to the better P/O ratio of glucose,glucose can be used more efficiently with the same oxygen amount than fatty acids. This leads to faster and more rapid ATP turnover which is ideal for tissues requiring fast energy. In terms of this,speed>quantity
Things that make fat oxidation worse is its increase in ROS. What this leads to:

-Increased superoxide (can metabolize into harmful compounds if levels are higher)
-More oxidative stress (more oxygen needed for ATP generation)
-A higher amount of prelipid oxidation

Glucose in comparison,is a way cleaner energy source for your cells.

View attachment 245609

This was it,I hope I don’t only get 2 reps for this since this is in my opinion the most High IQ thread I’ve made so far. Hopefully all low carb nigs will bow down to Ray Peat.


@Dean @Spuffy @Love @Phosphophilyte

Unironically good thread but fats yield more total arp per molecules , so in terms of oxygen efficiency and rapid atp supply ,glucose is the best

 

[Kaligula567]

Those who bump

Is it peak?

 

[Kaligula567]

Unironically good thread but fats yield more total arp per molecules , so in terms of oxygen efficiency and rapid atp supply ,glucose is the best

Thinking too much, foids don't need to think

 

[Kaligula567]

Unironically good thread but fats yield more total arp per molecules , so in terms of oxygen efficiency and rapid atp supply ,glucose is the best

Anyway can u go into my acc and post till @oath doesn't show up?

 

[Sherlock]

Anyway can u go into my acc and post till @oath doesn't show up?

yes , i’m going to take a bath before

 

[Kaligula567]

@cindythetvisleaking @xy2m @Thebird

 

[Kaligula567]

yes , i’m going to take a bath before

Yeye bath lady I'm gonna go to sleep please I count on u in this

 

[ecoli]

Lowkey I need to tag some nikkas noone online except this greyfag

@MogsGymMaxx @ecoli @Alurmo @GoryToad @+Enrique+

Peak

 

[Kaligula567]

Peak

Yeye ik

 

[Kaligula567]

Peak

Also rep the thread bhai cmon

 

[LOSER BITCH]

yes , i’m going to take a bath before

without me?

 

[ecoli]

Also rep the thread bhai cmon

I forgot sorry

 

[Kaligula567]

without me?

Lol

 

[Kaligula567]

I forgot sorry

Cool

 

[Kaligula567]

without me?

Mirin rad what u think abt this thread?

 

[Sherlock]

without me?

i’m 14

 

[Newday]

Imma match this so I can get Motm

 

[Kaligula567]

i’m 14

Rad is like 15

 

[Kaligula567]

Imma match this so I can get Motm

Yeye good for u

 

[Kaligula567]

Imma match this so I can get Motm

I ll lowkey never win that

 

[Kaligula567]

@giga.mia @RottingCarrie @iletheile @kifykify

 

[Kaligula567]

i’m 14

U better show up when u done with da bath

 

[Kaligula567]

Ima sleep @Pento @Phosphophilyte @Love @oath counting on u bhais u each got some job, now rly see ya tomorrow

 

[xy2m]

@cindythetvisleaking @xy2m @Thebird

yes

 

[LOSER BITCH]

i’m 14

idc

 

[LOSER BITCH]

Mirin rad what u think abt this thread?

good stuff lad

 

[Zynx✰]

Enough jestering and making water threads, yeye me and @Mandy? lowkey making this one for the niche niqqas here, full of top g info fr, thank my niqqa mandy for providing me with the niche info needed

View attachment 245607


First we will look deeply into the starting point where glucose utilization completely obliterates fat oxidation, ATP/O2 PR rate.
First of all, what exactly is the ATP/O2 PR rate? In short,it’s the rate of how much ATP you can generate with the rate of oxygen. The PO ratio (phosphate to oxygen) greatly determines this.

PO ratio of different ATP generation sources:

Glucose oxidation: 2.58-2.7 ATP per oxygen atom
Fat oxidation (palmitate): 2.33 ATP per oxygen atom
And what does this exactly prove? Mitochondria can more efficiently generate ATP using the same amount of oxygen with glucose than fat oxidation.

Benefits?

-Faster ATP generation
-increased CO2 production
-higher ATP throughput
-lower stress hormones
-lower ROS
-Activation of PDH

Low carb retards like to argue that fat oxidation of palmitate yields 3x more ATP than glucose,this is true with no denial. But generally this argument is useless due to what I’ve stated before on ATP/O2 PR rate and here’s why!

General ATP generation from different energy sources:

Glucose oxidation: ~32 ATP
Fat oxidation (palmitate):106 ATP

And that’s a huge difference,but why is this useless?

ATP demand isn’t heavily depended and based by the amount of molecules and general ATP is limited by enzyme and oxygen availability. Due to the better P/O ratio of glucose,glucose can be used more efficiently with the same oxygen amount than fatty acids. This leads to faster and more rapid ATP turnover which is ideal for tissues requiring fast energy. In terms of this,speed>quantity


Things that make fat oxidation worse is its increase in ROS. What this leads to:

-Increased superoxide (can metabolize into harmful compounds if levels are higher)

-More oxidative stress (more oxygen needed for ATP generation)

-A higher amount of prelipid oxidation


Glucose in comparison,is a way cleaner energy source for your cells.


View attachment 245609


This was it,I hope I don’t only get 2 reps for this since this is in my opinion the most High IQ thread I’ve made so far. Hopefully all low carb nigs will bow down to Ray Peat.


@Dean @Spuffy @Love @Phosphophilyte

good but your a bit wrong.

 

[Kaligula567]

good but your a bit wrong.

Elab or mumbai tales

 

[Zynx✰]

Elab or mumbai tales

ATP production is usually limited by enzyme capacity and demand, not oxygen efficiency. A higher P/O ratio does not imply jackshit, excess glycolytic flux can add more reactive byproducts, ros production depends on electron the transport chain backpressure, membrane thingy and this other one (forgot the name but starts with R)

Glucose only has an advantage when oxygen or ATP demand is limiting, fat doesn’t make more ROS, oxidative stress depends on mitochondrial redox and faster atp isn't always good, best to be at a equilibrium.

there's other stuff but this is what I've mainly noticed.

 

[Kaligula567]

ATP production is usually limited by enzyme capacity and demand, not oxygen efficiency. A higher P/O ratio does not imply jackshit, excess glycolytic flux can add more reactive byproducts, ros production depends on electron the transport chain backpressure, membrane thingy and this other one (forgot the name but starts with R)

Glucose only has an advantage when oxygen or ATP demand is limiting, fat doesn’t make more ROS, oxidative stress depends on mitochondrial redox and faster atp isn't always good, best to be at a equilibrium.

there's other stuff but this is what I've mainly noticed.

Ye sounds fancy but i guarantee u ur wrong

 

[vivi]

Enough jestering and making water threads, yeye me and @Mandy? lowkey making this one for the niche niqqas here, full of top g info fr, thank my niqqa mandy for providing me with the niche info needed

View attachment 245607


First we will look deeply into the starting point where glucose utilization completely obliterates fat oxidation, ATP/O2 PR rate.
First of all, what exactly is the ATP/O2 PR rate? In short,it’s the rate of how much ATP you can generate with the rate of oxygen. The PO ratio (phosphate to oxygen) greatly determines this.

PO ratio of different ATP generation sources:

Glucose oxidation: 2.58-2.7 ATP per oxygen atom
Fat oxidation (palmitate): 2.33 ATP per oxygen atom
And what does this exactly prove? Mitochondria can more efficiently generate ATP using the same amount of oxygen with glucose than fat oxidation.

Benefits?

-Faster ATP generation
-increased CO2 production
-higher ATP throughput
-lower stress hormones
-lower ROS
-Activation of PDH

Low carb retards like to argue that fat oxidation of palmitate yields 3x more ATP than glucose,this is true with no denial. But generally this argument is useless due to what I’ve stated before on ATP/O2 PR rate and here’s why!

General ATP generation from different energy sources:

Glucose oxidation: ~32 ATP
Fat oxidation (palmitate):106 ATP

And that’s a huge difference,but why is this useless?

ATP demand isn’t heavily depended and based by the amount of molecules and general ATP is limited by enzyme and oxygen availability. Due to the better P/O ratio of glucose,glucose can be used more efficiently with the same oxygen amount than fatty acids. This leads to faster and more rapid ATP turnover which is ideal for tissues requiring fast energy. In terms of this,speed>quantity


Things that make fat oxidation worse is its increase in ROS. What this leads to:

-Increased superoxide (can metabolize into harmful compounds if levels are higher)

-More oxidative stress (more oxygen needed for ATP generation)

-A higher amount of prelipid oxidation


Glucose in comparison,is a way cleaner energy source for your cells.


View attachment 245609


This was it,I hope I don’t only get 2 reps for this since this is in my opinion the most High IQ thread I’ve made so far. Hopefully all low carb nigs will bow down to Ray Peat.


@Dean @Spuffy @Love @Phosphophilyte

amazing thread tbh good job incel lord

 

[Kaligula567]

amazing thread tbh good job incel lord

Peak yo

 

[Nihilus]

Things are much much nuanced

ATP/O2 ratio isn't some holy grail , it holds little significance and not that the difference is great overall . Its only relevant during intense activities when you're not getting much oxygen

Regarding the speed of production of energy, yeah glucose is faster because it works in both anaerobic and aerobic environments and the whole pathway is shorter : glycolysis ==> krebs cycle
But this only matters depending on activity, if you're just chilling you want a continuous stable form of energy which comes from fats , if you're gonna be active its better to load up some carbs for better performance

And lastly the claim that fats produce more ROS is straight up wrong , i can make the same argument regarding Advanced glycation end products
And both arguments are weak , The extent of ROS depends on many factors such rate of ETC activity, antioxidant defenses, mitochondrial efficiency
There is no universal rule that fat oxidation always produces more harmful ROS than glucose oxidation under normal physiological conditions

 

[Zynx✰]

Ye sounds fancy but i guarantee u ur wrong

It’s backed by multiple studies that arnt bullshit, or at least I assume.

 

[Kaligula567]

It’s backed by multiple studies that arnt bullshit, or at least I assume.

Yeye this guide is peak ik

 

[Zynx✰]

Things are much much nuanced

ATP/O2 ratio isn't some holy grail , it holds little significance and not that the difference is great overall . Its only relevant during intense activities when you're not getting much oxygen

Regarding the speed of production of energy, yeah glucose is faster because it works in both anaerobic and aerobic environments and the whole pathway is shorter : glycolysis ==> krebs cycle
But this only matters depending on activity, if you're just chilling you want a continuous stable form of energy which comes from fats , if you're gonna be active its better to load up some carbs for better performance

And lastly the claim that fats produce more ROS is straight up wrong , i can make the same argument regarding Advanced glycation end products
And both arguments are weak , The extent of ROS depends on many factors such rate of ETC activity, antioxidant defenses, mitochondrial efficiency
There is no universal rule that fat oxidation always produces more harmful ROS than glucose oxidation under normal physiological conditions

Yeye this guide is peak ik

Cage at the gpt

 

[Nihilus]

Cage at the gpt

i am a biotech student , my child
we study like 12 hours of biochemistry weekly

 

[Zynx✰]

i am a biotech student , my child
we study like 12 hours of biochemistry weekly

For sure.

There’s clear use of ai lmafo, It’d be more believable if you’d used words that weren’t commonly used with ai Imao, @Kaligula567 cageful

 

[Nihilus]

For sure.

There’s clear use of ai lmafo, It’d be more believable if you’d used words that weren’t commonly used with ai Imao, @Kaligula567 cagefulView attachment 245779

thats just scientific/academic vocab and language , my child
believe what you want to believe

 

[Kaligula567]

thats just scientific/academic vocab and language , my child
believe what you want to believe

@Zynx✰ just hating brah

 

[Kaligula567]

For sure.

There’s clear use of ai lmafo, It’d be more believable if you’d used words that weren’t commonly used with ai Imao, @Kaligula567 cagefulView attachment 245779

Yeye dnr bro it's peak, no ai aaa usses

 

[Kaligula567]

Cage at the gpt

Doing too much

 

[tomahawk]

Gluconeogenesis.