Info Info Dump: Isotretinoin (Accutane)

[mtren]

@kys not a guide but good info

tonyDR needs to give me contirbuter since my recent one was as good as this

 

[genio]

tonyDR needs to give me contirbuter since my recent one was as good as this

I posted ts after getting contributor n****r

 

[mtren]

I posted ts after getting contributor n****r

lmfao

 

[mtren]

How does Isotretinoin work?
It kills sebocytes (the cells that produce sebum) which are the main cause of acne. It’s very hard to have acne without sebocytes as sebum is what clogs your pores allowing bacteria to form. It basically kills acne from its origin.
-Study

Other benefits on skin
It increases collagen production causing better skin elasticity and having a positive effect on photoaging skin.
-Study

Misconceptions about Isotretinoin
-“But saar, it has so many side effects.”
This is true at standard dosages, but can EASILY be avoided with correct dosing. Do not take large amounts of Isotretinoin within a short time frame, but rather spread it out. Cumulative dose has been shown to be one of the most important factors when taking Isotretinoin. You’ll experience the same skin benefits with minimal side effects if you take a low dose over a longer span of time. Note that you'll have a higher chance of relapse if you do get off though as compared to a high dose over a short time.
For example:
3000mg over 1 month = Clear skin, skin benefits, but a lot of side effects (most likely to not relapse if you get off)
3000mg over 6 months = Same clear skin and skin benefits, but minimal side effects (more likely to relapse if you get off)
-Study 1, Study 2, Study 3

-“But saar, it’ll stunt my growth if I take it during puberty”
Studies have shown that Isotretinoin decreases HGH, IGF-1, testosterone, etc. in pubescent boys, but this will only slow your growth velocity and will not stunt your final adult height. Long bones like the ones involved in growth experience catch-up growth, so you’ll be fine.
-Study 1, Study 2, Study 3, Study 4

osing and Internal Risks​

You cannot treat dosing like a "cycle" to bypass all side effects. Isotretinoin is systemic; it affects your liver and lipid levels regardless of the pacing. High doses don't just cause "annoying" side effects; they can cause significant metabolic and hepatic (liver) stress. https://cdn.mdedge.com/files/s3fs-public/Document/September-2017/CT094110234.pdf

The Anti-Aging opine​

Isotretinoin is not an FDA-approved anti-aging drug. While some small, non-controlled studies looked at it for photoaging, it is not standard care. Retinoid creams (like tretinoin) are the gold standard for that; oral isotretinoin is for severe, recalcitrant acne. https://www.ovid.com/journals/ijder...isotretinoin-versus-topical-retinoic-acid-for https://dermondemand.com/blog/accutane-and-wrinkles/

Hormones and Growth​

While the consensus is that final adult height is generally not stunted, the drug does cause documented changes in hormonal markers like IGF-1 (Insulin-like Growth Factor 1). Treating your endocrine system like it’s immune to a powerful systemic drug during your prime growth years is not supported by the medical reality of how the drug works. https://pubmed.ncbi.nlm.nih.gov/20128787/

General Consensus on Dosing​

The "low-dose vs. high-dose" debate is a clinical one, not an internet claim. Dermatologists weigh the cumulative dose required to prevent relapse against the patient's ability to tolerate side effects. Doing this without a doctor means you lack the baseline blood work necessary to catch liver or lipid issues before they become permanent damage. https://consensus.app/search/is-low...ffective-as-standard-/ftEIiiaEQ86XDa9lU4ey5g/


@Jews

 

[mtren]

osing and Internal Risks​

You cannot treat dosing like a "cycle" to bypass all side effects. Isotretinoin is systemic; it affects your liver and lipid levels regardless of the pacing. High doses don't just cause "annoying" side effects; they can cause significant metabolic and hepatic (liver) stress. https://cdn.mdedge.com/files/s3fs-public/Document/September-2017/CT094110234.pdf

The Anti-Aging opine​

Isotretinoin is not an FDA-approved anti-aging drug. While some small, non-controlled studies looked at it for photoaging, it is not standard care. Retinoid creams (like tretinoin) are the gold standard for that; oral isotretinoin is for severe, recalcitrant acne. https://www.ovid.com/journals/ijder...isotretinoin-versus-topical-retinoic-acid-for https://dermondemand.com/blog/accutane-and-wrinkles/

Hormones and Growth​

While the consensus is that final adult height is generally not stunted, the drug does cause documented changes in hormonal markers like IGF-1 (Insulin-like Growth Factor 1). Treating your endocrine system like it’s immune to a powerful systemic drug during your prime growth years is not supported by the medical reality of how the drug works. https://pubmed.ncbi.nlm.nih.gov/20128787/

General Consensus on Dosing​

The "low-dose vs. high-dose" debate is a clinical one, not an internet claim. Dermatologists weigh the cumulative dose required to prevent relapse against the patient's ability to tolerate side effects. Doing this without a doctor means you lack the baseline blood work necessary to catch liver or lipid issues before they become permanent damage. https://consensus.app/search/is-low...ffective-as-standard-/ftEIiiaEQ86XDa9lU4ey5g/


@Jews

@Idontknow-

 

[mtren]

@Idontknow-

osing and Internal Risks​

You cannot treat dosing like a "cycle" to bypass all side effects. Isotretinoin is systemic; it affects your liver and lipid levels regardless of the pacing. High doses don't just cause "annoying" side effects; they can cause significant metabolic and hepatic (liver) stress. https://cdn.mdedge.com/files/s3fs-public/Document/September-2017/CT094110234.pdf

The Anti-Aging opine​

Isotretinoin is not an FDA-approved anti-aging drug. While some small, non-controlled studies looked at it for photoaging, it is not standard care. Retinoid creams (like tretinoin) are the gold standard for that; oral isotretinoin is for severe, recalcitrant acne. https://www.ovid.com/journals/ijder...isotretinoin-versus-topical-retinoic-acid-for https://dermondemand.com/blog/accutane-and-wrinkles/

Hormones and Growth​

While the consensus is that final adult height is generally not stunted, the drug does cause documented changes in hormonal markers like IGF-1 (Insulin-like Growth Factor 1). Treating your endocrine system like it’s immune to a powerful systemic drug during your prime growth years is not supported by the medical reality of how the drug works. https://pubmed.ncbi.nlm.nih.gov/20128787/

General Consensus on Dosing​

The "low-dose vs. high-dose" debate is a clinical one, not an internet claim. Dermatologists weigh the cumulative dose required to prevent relapse against the patient's ability to tolerate side effects. Doing this without a doctor means you lack the baseline blood work necessary to catch liver or lipid issues before they become permanent damage. https://consensus.app/search/is-low...ffective-as-standard-/ftEIiiaEQ86XDa9lU4ey5g/


@Jews

@foidslayer @emeraldpill (anything for reps guys)

 

[genio]

osing and Internal Risks​

You cannot treat dosing like a "cycle" to bypass all side effects. Isotretinoin is systemic; it affects your liver and lipid levels regardless of the pacing. High doses don't just cause "annoying" side effects; they can cause significant metabolic and hepatic (liver) stress. https://cdn.mdedge.com/files/s3fs-public/Document/September-2017/CT094110234.pdf

The Anti-Aging opine​

Isotretinoin is not an FDA-approved anti-aging drug. While some small, non-controlled studies looked at it for photoaging, it is not standard care. Retinoid creams (like tretinoin) are the gold standard for that; oral isotretinoin is for severe, recalcitrant acne. https://www.ovid.com/journals/ijder...isotretinoin-versus-topical-retinoic-acid-for https://dermondemand.com/blog/accutane-and-wrinkles/

Hormones and Growth​

While the consensus is that final adult height is generally not stunted, the drug does cause documented changes in hormonal markers like IGF-1 (Insulin-like Growth Factor 1). Treating your endocrine system like it’s immune to a powerful systemic drug during your prime growth years is not supported by the medical reality of how the drug works. https://pubmed.ncbi.nlm.nih.gov/20128787/

General Consensus on Dosing​

The "low-dose vs. high-dose" debate is a clinical one, not an internet claim. Dermatologists weigh the cumulative dose required to prevent relapse against the patient's ability to tolerate side effects. Doing this without a doctor means you lack the baseline blood work necessary to catch liver or lipid issues before they become permanent damage. https://consensus.app/search/is-low...ffective-as-standard-/ftEIiiaEQ86XDa9lU4ey5g/


@Jews

Pull quotes from that long ass first source
Patients on low-dose accutane had significantly less side effects n***a

Secondly, i included photoaging as an extra benefit, i never suggested it as standard care, but rather an extra bonus
You agree that it’s been found to help photoaging

Third, i did acknowledge that it drops igf-1
And again, my whole claim is that it doesnt stunt final adult height, which you agree with

Fourth, i never said not to do your baseline bloodwork? I just stated a protocol that would give you less side effects based on studies shown

 

[mtren]

Pull quotes from that long ass first source
Patients on low-dose accutane had significantly less side effects n***a

Secondly, i included photoaging as an extra benefit, i never suggested it as standard care, but rather an extra bonus
You agree that it’s been found to help photoaging

Third, i did acknowledge that it drops igf-1
And again, my whole claim is that it doesnt stunt final adult height, which you agree with

Fourth, i never said not to do your baseline bloodwork? I just stated a protocol that would give you less side effects based on studies shown

Sorry im too lazy to go back n forth your right

 

[James]

Tbh I'm to paranoid to take that for growth

its mainly negative if you chronically use it in the higher dosages, you can see that in the recent papers that the stunt in growth velocity doesn't really effect FAH, due to catchup-growth. All systemic retinoids will binds to RARS in chondrocytes, making it negative through things like it being anti-proliferative.

 

[genio]

its mainly negative if you chronically use it in the higher dosages, you can see that in the recent papers that the stunt in growth velocity doesn't really effect FAH, due to catchup-growth. All systemic retinoids will binds to RARS in chondrocytes, making it negative through things like it being anti-proliferative.

Hes too low iq for that

 

[amore]

it is what it is. i don't know what to say to that besides "what."

 

[submissivechud]

cum on skin for primal