Theory KY19382 - Treatment für baldcels and shortcels?

[RandyWendy]

So I've been watching one of Kevin Mann's hairloss videos where he talks about a substance called KY19382. This substance supposedly affects (activates) the WNT pathway and is being researched as a potential hair growth stimulant, but also has another interesting mechanism of action...

At 6:45 he cites a study:

KY19382 is one of the newly synthesized analogues of indirubin‐3′‐monoxime (I3O), a glycogen synthase kinase‐3β (GSK‐3β) inhibitor, and has a significant ability to activate Wnt/β‐catenin signalling (Choi et al., 2019). Indirubin is an active ingredient of the indigo plant, Danggui Longhui Wan, used as traditional anti‐leukaemia medicine (Xiao et al., 2002). I3O is known to be a Wnt/β‐catenin activator that stabilizes β‐catenin via inhibition of GSK‐3β and has been shown to accelerate bone growth and inhibit adipogenesis (Cha & Choi, 2014; Choi et al., 2014; Zahoor et al., 2014). Furthermore, we recently found that KY19382 elongated tibial length by inactivating GSK‐3β and blocking the binding of CXXC‐type zinc finger protein 5 (CXXC5) and dishevelled (Dvl) (Choi et al., 2019). Moreover, PTD‐DBM, a peptide that interferes with CXXC5–Dvl interaction via binding to the PDZ domain of Dvl, stimulated wound‐induced hair follicle neogenesis (WIHN) and hair regrowth (Lee et al., 2017). However, this peptide is limited for routine application due to its cost and stability.

sources:

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8251890/

https://www.researchgate.net/figure...d-longitudinal-bone-growth-A-I_fig4_332334669

https://www.researchgate.net/figure...ion-of-growth-plate-senescence_fig1_332334669

Could this be it? A potential medicinal substance für shortcels?

 

[RandyWendy]

They literally just finished a phase 1 study in China. Still many years to go...

https://www.folliclethought.com/ptd-dbm-update-qa-with-dr-kang-yell-choi/

 

[RandyWendy]

How about a Group Buy?

 

[Neo]

Can't believe I ignored this thread.

 

[Buddy Boyo]

Can't believe I ignored this thread.

can i have tit milk?

 

[King]

interesting
but

this peptide is limited for routine application due to its cost and stability.

 

[RandyWendy]

interesting
but

Creating a more stable complex might be only a matter of time. Prices at early research stages are quite high...

 

[MrRubiks]

Wouldn't this require the growth plates to be unfused? You can augment growth before they fuse, but if you try too late your only option is limb lengthening.

 

[RandyWendy]

Wouldn't this require the growth plates to be unfused? You can augment growth before they fuse, but if you try too late your only option is limb lengthening.

I am not sure. Depends on its mechanism which I don't fully understand!

 

[RandyWendy]

But we have to keep an eye on this one. Seems kinda promising.

 

[RandyWendy]

Breakthrough-Indirubin looks like a very promising height increase compound - Natural Height Growth

Indirubin has shown promise before as a CXXC5 inhibitor. ” elongated tibial length through delayed senescence and further activation of the growth plate in adolescent mice.”<-further activation of the growth plate is what is most interesting. We have to be on the lookout for indirubin...

www.naturalheightgrowth.com

CXXC5

It looks like Cxxc5 could be an important factor. CXXC5 mediates growth plate senescence and is a target for enhancement of longitudina...

www.heightquest.com

LSJL.info-According to Natural Height Growth, indirubin derivative, KY19382, could be a promising height increase compound

Hi Everyone, I found this interesting article on Natural Height Growth website that says indirubin derivative, KY19382, could be a promising height in

www.tapatalk.com

Sounds kinda promising!

 

[Rkelly]

Breakthrough-Indirubin looks like a very promising height increase compound - Natural Height Growth

Indirubin has shown promise before as a CXXC5 inhibitor. ” elongated tibial length through delayed senescence and further activation of the growth plate in adolescent mice.”<-further activation of the growth plate is what is most interesting. We have to be on the lookout for indirubin...

www.naturalheightgrowth.com

CXXC5

It looks like Cxxc5 could be an important factor. CXXC5 mediates growth plate senescence and is a target for enhancement of longitudina...

www.heightquest.com

LSJL.info-According to Natural Height Growth, indirubin derivative, KY19382, could be a promising height increase compound

Hi Everyone, I found this interesting article on Natural Height Growth website that says indirubin derivative, KY19382, could be a promising height in

www.tapatalk.com

Sounds kinda promising!

Why do you keep coping with chemical compounds that may or may not (most likely) work? Not to mention the various unwanted side effects... Just save up for LL then wear lifts or elevator shoes.

 

[RandyWendy]

Why do you keep coping with chemical compounds that may or may not (most likely) work? Not to mention the various unwanted side effects... Just save up for LL then wear lifts or elevator shoes.

Chemical way is the way to go.

LL is for dumb losers.

 

[Rkelly]

LL is for dumb losers.

Tell that to @MrRubiks

 

[MrRubiks]

Tell that to @MrRubiks

lol I can only assume he's joking.

I'm pretty sure that once the growth plates have fused any chemical approach is nothing more than a pipe dream.

 

[RandyWendy]

Tell that to @MrRubiks

I you want to be a non-athletic weak human with arthritis, then go for Limb Lengthening Surgery.

 

[MrRubiks]

I you want to be a non-athletic weak human with arthritis, then go for Limb Lengthening Surgery.

Challenge accepted! I'll quote you again after I succeed.

And I'm pretty sure that arthritis only occurs as a result of poor alignment, which causes uneven wear on the joints. Assuming alignment is good (like mine), why would I expect to develop arthritis?

 

[RandyWendy]

Challenge accepted! I'll quote you again after I succeed.

And I'm pretty sure that arthritis only occurs as a result of poor alignment, which causes uneven wear on the joints. Assuming alignment is good (like mine), why would I expect to develop arthritis?

Sure bro! I am awaiting your results.

 

[RandyWendy]

Anyone tried this stuff?

 

[RandyWendy]

can i have tit milk?

No, only buttermilk...

 

[RandyWendy]

Challenge accepted! I'll quote you again after I succeed.

And I'm pretty sure that arthritis only occurs as a result of poor alignment, which causes uneven wear on the joints. Assuming alignment is good (like mine), why would I expect to develop arthritis?

 

[MrRubiks]

Update: I did running for the first time a few days ago. I can do it without issue (kinesthetically), but it hurts the screw sites in my tibias, so I'm probably going to hold off until I get the nails removed. My strength on the leg press has also gone up considerably.