Oxytocin

[deutscher]

Can someone over explain how Oxytocin helps for bone growth?

 

[Ashez]

smth to do with osteoblasts

 

[arf]

okay so oxytocin that love hormone thing your brain pumps out when you hug people or whatever actually straight up helps your bones grow and get stronger by messing with the cells that build and break down bone and it's kinda wild cuz it's not just about feelings, basically bones are always remodeling with osteoblasts as the builders that make new bone matrix and mineralize it with calcium and stuff while osteoclasts are the breakers that chew up old bone so new stuff can replace it but oxytocin hooks onto receptors on both and mainly cranks up the builders big time by telling bone marrow stem cells to turn into osteoblasts instead of fat cells which is huge cuz old people get fatty marrow and weaker bones, it boosts genes like bmp-2 runx2 osterix and atf-4 so the cells mature faster make more alkaline phosphatase osteocalcin and osteopontin and actually lay down real solid mineralized bone plus it spikes calcium inside the cells and flips on erk mapk pathways to get the nucleus working overtime while with the osteoclasts it's mixed like it might help make a few more by raising rankl and lowering opg but then on the mature ones it calms them down with nitric oxide and sustained calcium so they don't destroy as much bone meaning net you get way more building than breaking and better bone structure, plus it teams up with estrogen cuz estrogen makes osteoblasts produce oxytocin locally creating this positive feedback loop that protects bones especially in women and when estrogen drops after menopause oxytocin can drop too which is why bones get weak but giving extra oxytocin in studies on mice fixes low bone formation and even reverses some osteoporosis stuff by making denser stronger bones with less marrow fat and it all works as both a hormone from the pituitary and a local paracrine signal right in the bone marrow so yeah it's like this anabolic bone builder that overexplains why feeling loved or getting hugs might secretly be good for your skeleton too lol.

DNR'D MYSELF AFTER THIS BTW and didnt backread it solution worthy

 

[genio]

okay so oxytocin that love hormone thing your brain pumps out when you hug people or whatever actually straight up helps your bones grow and get stronger by messing with the cells that build and break down bone and it's kinda wild cuz it's not just about feelings, basically bones are always remodeling with osteoblasts as the builders that make new bone matrix and mineralize it with calcium and stuff while osteoclasts are the breakers that chew up old bone so new stuff can replace it but oxytocin hooks onto receptors on both and mainly cranks up the builders big time by telling bone marrow stem cells to turn into osteoblasts instead of fat cells which is huge cuz old people get fatty marrow and weaker bones, it boosts genes like bmp-2 runx2 osterix and atf-4 so the cells mature faster make more alkaline phosphatase osteocalcin and osteopontin and actually lay down real solid mineralized bone plus it spikes calcium inside the cells and flips on erk mapk pathways to get the nucleus working overtime while with the osteoclasts it's mixed like it might help make a few more by raising rankl and lowering opg but then on the mature ones it calms them down with nitric oxide and sustained calcium so they don't destroy as much bone meaning net you get way more building than breaking and better bone structure, plus it teams up with estrogen cuz estrogen makes osteoblasts produce oxytocin locally creating this positive feedback loop that protects bones especially in women and when estrogen drops after menopause oxytocin can drop too which is why bones get weak but giving extra oxytocin in studies on mice fixes low bone formation and even reverses some osteoporosis stuff by making denser stronger bones with less marrow fat and it all works as both a hormone from the pituitary and a local paracrine signal right in the bone marrow so yeah it's like this anabolic bone builder that overexplains why feeling loved or getting hugs might secretly be good for your skeleton too lol.

DNR'D MYSELF AFTER THIS BTW and didnt backread it solution worthy

Dnr n****r