Guide Trenbolone intro and guide

[Hypertrophy]

Wouldn't really say this is inherently true , both anavar and tren will crush up SHBG freeing up test to convert into DHT which will be the main driver of hair loss.

Tren (low dose) and anavar in themselves are quite hair safe most the hair loss would be DHT driven

Thats true. Thats why I recommended a low test dose to him

 

[Say yes to heaven]

Missing lots of information 5/10
For the cardiovascular don't use compounds that crosses BBB (lipids)

Neurotoxicity not bad still needs work

Actually tbh everything does

 

[Hypertrophy]

Missing lots of information 5/10
For the cardiovascular don't use compounds that crosses BBB (lipids)

Neurotoxicity not bad still needs work

Actually tbh everything does

Forgive me saar

 

[Say yes to heaven]

Forgive me saar

It's still the best guide iv seen on it between org .GG and .com it's just I'm picky

 

[Hypertrophy]

It's still the best guide iv seen on it between org .GG and .com it's just I'm picky

Im curious as to what you would've wanted to see from this guide

Like specific information I missed

 

[Say yes to heaven]

Im curious as to what you would've wanted to see from this guide

Like specific information I missed

Oki give me a second I'm just going to work on the accileries I'm too lazy to rewrite the thread basically

 

[Say yes to heaven]

Neuroprotections

You shouldn't use this as a guide; I meant it as a way for you to look at neuroprotection in a different light i also left out details and a few drugs that are amazing that im gate keeping as im weird and waiting to write a thread about it i wouldn't go as much details on the other parts but u did leave out quite a lot forgot the blood work section, labs, organ protection and more


Note: since there's little data on its neurological effects, use other 19-nors for reference

Lipophilicity. BBB. Placental and Hippocampal accumulation

As you know, there isn't a way to fix this issue, but there's a theory that longer esters help

AR + PR + weak GR block + no ER

ER is absent, so just run TRT; all the other stuff is just impossible, or I forgot

AR-independent cell injury (neurites, mitochondria, Tubb3)

Mito
SS-31 / elamipretide and MOTS-c

Spoiler: other drugs

SkQ1
MA-5
NMNH/NMN
Humanin
urolithin A
creatine
edaravone
emoxypine

Neurites / TrkB

ACD856
Dihexa
Semax etc
P-21
NSI-189
J-147

After clearance

Cerebrolysin
Cortexin
Cortagen.

Amyloid / hippocampal apoptosis

Aβ42 up, presenilin-1 down, caspase-3.

ACD856 (amyloid/energy protection).
Huperzine A, donepezil, rivastigmine, galantamine (Alzheimer)
Lithium as GSK-3/mood.


Excitotoxicity / NMDA / calcium

memantine.
Nimodipine if used (hypotension; SAH drug)
Carnosic acid / NACET / glutathione (oxidative)
Magnesium as a weak buffer.


Tau / GSK-3β

This has thin trenbolone data.

Lithium & sulforaphane.
As a theory

Oxidative stress/mitophagy

Downstream of mitochondrial failure.

NACET/glutathione/carnosic acid/sulforaphane/astaxanthin/curcumin/emoxypine/edaravone.
Urolithin A for mitophagy.
SS-31

Neuroinflammation / missing estradiol

LCN2 / cytokines in models. No local E2.

Minocycline & DHA
S-equol as ERβ theory
ik kids love to crush estrogen with AI

MAO/dopamine/lipids

selegiline/rasagiline/safinamide
Bromantane/ 9-Me-BC.l for the NA alarm.
Bupropion if your depression


Synapses / TACR3 / adolescent circuits

PSD95, gephyrin, synaptophysin, dentate activity, mPFC dopamine axons, BDNF / Dcc etc

ACD856, Dihexa, Semax, TAK-653/IDRA-21.

Sleep
Amplifies anger, fog, threat, etc.

lemborexant or daridorexant
Melatonin/ramelteon/DSIP as cues.

​

 

[Hypertrophy]

Neuroprotections

You shouldn't use this as a guide; I meant it as a way for you to look at neuroprotection in a different light i also left out details and a few drugs that are amazing that im gate keeping as im weird and waiting to write a thread about it i wouldn't go as much details on the other parts but u did leave out quite a lot forgot the blood work section, labs, organ protection and more


Note: since there's little data on its neurological effects, use other 19-nors for reference

Lipophilicity. BBB. Placental and Hippocampal accumulation

As you know, there isn't a way to fix this issue, but there's a theory that longer esters help

AR + PR + weak GR block + no ER

ER is absent, so just run TRT; all the other stuff is just impossible, or I forgot

AR-independent cell injury (neurites, mitochondria, Tubb3)

Mito
SS-31 / elamipretide and MOTS-c

Spoiler: other drugs

SkQ1
MA-5
NMNH/NMN
Humanin
urolithin A
creatine
edaravone
emoxypine

Neurites / TrkB

ACD856
Dihexa
Semax etc
P-21
NSI-189
J-147

After clearance

Cerebrolysin
Cortexin
Cortagen.

Amyloid / hippocampal apoptosis

Aβ42 up, presenilin-1 down, caspase-3.

ACD856 (amyloid/energy protection).
Huperzine A, donepezil, rivastigmine, galantamine (Alzheimer)
Lithium as GSK-3/mood.


Excitotoxicity / NMDA / calcium

memantine.
Nimodipine if used (hypotension; SAH drug)
Carnosic acid / NACET / glutathione (oxidative)
Magnesium as a weak buffer.


Tau / GSK-3β

This has thin trenbolone data.

Lithium & sulforaphane.
As a theory

Oxidative stress/mitophagy

Downstream of mitochondrial failure.

NACET/glutathione/carnosic acid/sulforaphane/astaxanthin/curcumin/emoxypine/edaravone.
Urolithin A for mitophagy.
SS-31

Neuroinflammation / missing estradiol

LCN2 / cytokines in models. No local E2.

Minocycline & DHA
S-equol as ERβ theory
ik kids love to crush estrogen with AI

MAO/dopamine/lipids

selegiline/rasagiline/safinamide
Bromantane/ 9-Me-BC.l for the NA alarm.
Bupropion if your depression


Synapses / TACR3 / adolescent circuits

PSD95, gephyrin, synaptophysin, dentate activity, mPFC dopamine axons, BDNF / Dcc etc

ACD856, Dihexa, Semax, TAK-653/IDRA-21.

Sleep
Amplifies anger, fog, threat, etc.

lemborexant or daridorexant
Melatonin/ramelteon/DSIP as cues.

​

I had minocycline in my notes but then just didn't elaborate on it jfl

Thanks for the insight though ill definitely research the compounds I'm undereducated on here

 

[Say yes to heaven]

I had minocycline in my notes but then just didn't elaborate on it jfl

Thanks for the insight though ill definitely research the compounds I'm undereducated on here

bro ngl there a lot of things that people miss when talking about roids in guides for good reason; it's not covered or too complicated

 

[Hypertrophy]

bro ngl there a lot of things that people miss when talking about roids in guides for good reason; it's not covered or too complicated

I feel like I'm always learning about new anciliries lol

 

[Say yes to heaven]

Like some of these compounds im properly the first one to mention it

 

[Say yes to heaven]

I feel like I'm always learning about new anciliries lol

Yeah, for example, I have a list of 500 neuro compounds to cover; it never ends

 

[Hypertrophy]

Yeah, for example, I have a list of 500 neuro compounds to cover; it never ends

Once you explore one door ten more open in its place

 

[Say yes to heaven]

Once you explore one door ten more open in its place

Agreed; I have a project that never seems to end, but its nessary iv planed to stay awake 36hr, finish skimming 50% of it, then fill out the details

 

[Hypertrophy]

Agreed; I have a project that never seems to end, but its nessary iv planed to stay awake 36hr, finish skimming 50% of it, then fill out the details

You gonna post it here?

Do you post these projects on tt at all? I'm curious

 

[smbleh]

bro ngl there a lot of things that people miss when talking about roids in guides for good reason; it's not covered or too complicated

kind of depends , there's also a point of diminishing return with adding more anc on already very covered pathways and also the time expenditure needed to discover something to improve your stack by a very marginal amount + expenses , the goal shouldn't be to run the biggest polypharmacy you can , if anything the opposite , more variables to add complication

though on the neuro side of things it is overlooked alot for sure

 

[Say yes to heaven]

kind of depends , there's also a point of diminishing return with adding more anc

my biggest criticism is that people run the wrong compounds or suboptimal ones

on already very covered pathways and also the time expenditure needed to discover something to improve your stack by a very marginal amount +

if you know what you're doing, it can improve a stack by quite a margin i can give an example your on 500 test e. but not getting the results you want. What do you do?


Option 1: increase the test dose
adding more unnecessary sides + the diminished results may be due to myosin; there's a study that shows a cut-off in exponential growth with more test

Option 2: add another compound '


Example: gh and eq

If he wants more, maybe fast-acting insulin





Which option would be better

expenses , the goal shouldn't be to run the biggest polypharmacy you can , if anything the opposite ,

if you can't afford it, what's going to happen when you gotta pay medical bills, example: labs

more variables to add complication

then u didn't plan correctly, and it's a skill issue

though on the neuro side of things it is overlooked alot for sure

a lot of sides are overlooked, and undetectable without lab, not just neuro; that slowly builds up, that becomes life-threatening

 

[Say yes to heaven]

You gonna post it here?

Do you post these projects on tt at all? I'm curious

cant say much

 

[smbleh]

my biggest criticism is that people run the wrong compounds or suboptimal ones

if you know what you're doing, it can improve a stack by quite a margin i can give an example your on 500 test e. but not getting the results you want. What do you do?


Option 1: increase the test dose
adding more unnecessary sides + the diminished results may be due to myosin; there's a study that shows a cut-off in exponential growth with more test

Option 2: add another compound '


Example: gh and eq

If he wants more, maybe fast-acting insulin





Which option would be better

I meant more so health pathways being diminished but yeah obviously the actual compound selection matters , going above 300 test in general is usually a poor cycle choice imo due to selectivity

Which option would be better


if you can't afford it, what's going to happen when you gotta pay medical bills, example: labs

then u didn't plan correctly, and it's a skill issue

a lot of sides are overlooked, and undetectable without lab, not just neuro; that slowly builds up, that becomes life-threatening

again im referring to unnecessary expenses , eg. adding ancillaries for pathways that are already very protected , obviously things like bloodwork that are mandatory should be non negotiable

then u didn't plan correctly, and it's a skill issue

a lot of sides are overlooked, and undetectable without lab, not just neuro; that slowly builds up, that becomes life-threatening

not really a skill issue , many people are running very experimental polypharmacies with no actual outcome data , we can mash together all mechanisms and whatnot but we obviously know mechanisms and outcomes aren't always as should be , the less variables the better , even if all mechanisms are sounds and things should be synergistic and every compound has good outcome data , this doesn't mean things go according to plan and when u are running such huge polypharmacy it becomes practically impossible to isolate for sides and yes ofc blood work is a no brainer it matters more than any ancillary

 

[idkrandomhere]

me and @trenghost r not reading this

 

[Yeat]

me and @trenghost r not reading this

I read it

 

[idkrandomhere]

I read it

traitor

 

[Yeat]

traitor

fym traitor
also why are you tagging me in this I was already tagged

 

[Hypertrophy]

me and @trenghost r not reading this

You're a woman, I wouldn't expect you to read

 

[idkrandomhere]

You're a woman, I wouldn't expect you to read

ok brodie

 

[Yeat]

You're a woman, I wouldn't expect you to read

ye why would a woman read this

 

[Hypertrophy]

ye why would a woman read this

I need a cig

 

[Yeat]

I need a cig

where the fuck my blunt
where the fuck my cup where tf my reefer