Discussion Why bad interaction

[Archelaus]

Info HOW TGF-ẞ AGONISTS WORK, THEIR INTERACTION WITH HDACI, AND THEIR POTENTIAL FOR TARGETED SKELETAL ENHANCEMENT

Aug 16, 2025

TGF-B's Role in Bone Growth

1. Mechanisms of Action

TGF-B signaling influences bone development through:

Stimulation of Mesenchymal Stem Cells (MSCs) → Drives osteoblast and chondrocyte differentiation.

Enhancement of Extracellular Matrix (ECM) Deposition → Boosts collagen, osteocalcin, and alkaline phosphatase activity.

Modulation of Growth Plate Chondrocytes → Supports longitudinal bone growth before epiphyseal closure.



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2. TGF-B vs. BMP Signaling

While BMPs primarily drive osteoblast differentiation, TGF-B has a broader regulatory role:

Early-stage osteogenesis (MSC...

• Archelaus
• Replies: 10
• Forum: Looksmaxxing

• 

why

 

[Mandy?]

Only Low IQ’s don’t understand these type of threads my friend.

 

[Deleted Member 80294]

gives GPT vibes and overly complex

 

[Archelaus]

Only Low IQ’s don’t understand these type of threads my friend.

Tbh i always tag you cuz ik you're smart af

 

[dipenhydramine]

99% of people dont know what half this shit means you gotta use simple words

 

[Mandy?]

I like the thread,TGF beta agonists are one of the ways to help heightmaxx till genetic limit.

 

[tulip]

Info HOW TGF-ẞ AGONISTS WORK, THEIR INTERACTION WITH HDACI, AND THEIR POTENTIAL FOR TARGETED SKELETAL ENHANCEMENT

Aug 16, 2025

TGF-B's Role in Bone Growth

1. Mechanisms of Action

TGF-B signaling influences bone development through:

Stimulation of Mesenchymal Stem Cells (MSCs) → Drives osteoblast and chondrocyte differentiation.

Enhancement of Extracellular Matrix (ECM) Deposition → Boosts collagen, osteocalcin, and alkaline phosphatase activity.

Modulation of Growth Plate Chondrocytes → Supports longitudinal bone growth before epiphyseal closure.



---

2. TGF-B vs. BMP Signaling

While BMPs primarily drive osteoblast differentiation, TGF-B has a broader regulatory role:

Early-stage osteogenesis (MSC...

• Archelaus
• Replies: 10
• Forum: Looksmaxxing

• 

why

Because it's fucking useless. You people don't even create guides that the members ask for, just random shit that pops into your head. Listen to people first.

 

[doll]

probably because Its a topic that not many people here know about + looksmaxxing threads usually dont get a lot of replies which leads to less people seeing It

mirin ur thread tho

 

[Archelaus]

gives GPT vibes and overly complex

Chat gpt gives misinformation, u could ask it about this stuff and it'll give u wrong answers, it thinks muscle is built by micro tears + I'm sorry, I'm always trying to make it as simple as possible

 

[Archelaus]

99% of people dont know what half this shit means you gotta use simple words

well the words used r usually irreplaceable, although I'll try harder to make it simpler

 

[Mandy?]

Chat gpt gives misinformation, u could ask it about this stuff and it'll give u wrong answers, it thinks muscle is built by micro tears + I'm sorry, I'm always trying to make it as simple as possible

You should be the next version,not a insult.

 

[dipenhydramine]

Because it's fucking useless. You people don't even create guides that the members ask for, just random shit that pops into your head. Listen to people first.

as much as i dislike u this might be the first agreeable thing u have said

 

[Archelaus]

probably because Its a topic that not many people here know about + looksmaxxing threads usually dont get a lot of replies which leads to less people seeing It

mirin ur thread tho

Interesting, Ig the section is mostly dead, thanks also

 

[Mandy?]

Because it's fucking useless. You people don't even create guides that the members ask for, just random shit that pops into your head. Listen to people first.

But no one literally asks for them?

 

[Archelaus]

You should be the next version,not a insult.

 

[Deleted Member 80294]

 

[Mandy?]

But no one literally asks for them?

I’ve never heard someone ask me “Mandy make a guide about… I’m interested.”,plus most things are water and new ideas are hard to think off when every method is known.

 

[tulip]

But no one literally asks for them?

Do people not give suggestions you wall hoping shitskin

 

[Archelaus]

I’ve never heard someone ask me “Mandy make a guide about… I’m interested.”,plus most things are water and new ideas are hard to think off when every method is known.

Yess, suggestions would help people like us alot, idk why no one bothers tho

 

[tulip]

as much as i dislike u this might be the first agreeable thing u have said

You dont have to announce you dislike me. Grow up. Why do people on this incel forum act as though they're forced to interact with others. You chose to log in this morning yet again, without putting me on ignore. Just rope if even this is hard for you

 

[Mandy?]

Do people not give suggestions you wall hoping shitskin

Literally no and what the fuck did I do wrong for you to insult me.

 

[tulip]

Literally no and what the fuck did I do wrong for you to insult me.

Instant victim role, get a fucking grip.

 

[Mandy?]

Yess, suggestions would help people like us alot, idk why no one bothers tho

It’s dominantly not even a looksmaxxing forum. There are tons of users who probably haven’t posted a single post in the looksmaxxing subforum?

 

[dipenhydramine]

You dont have to announce you dislike me. Grow up. Why do people on this incel forum act as though they're forced to interact with others. You chose to log in this morning yet again, without putting me on ignore. Just rope if even this is hard for you

-person on an incel forum purely to play out a quirky mentally unwell fantasty to compensate for the lack of life you have irl

 

[Mandy?]

Instant victim role, get a fucking grip.

I never said I was the victim,can’t I fucking ask what I did? You should get a grip because how retarded must you be to go around be like this for no reason

 

[tulip]

-person on an incel forum purely to play out a quirky mentally unwell fantasty to compensate for the lack of life you have irl

No i'm here to read guides, I'm 15 have a good education, great social and hobbies; kickboxing,dancing, songwriting and singing. None of the lies you wrote up there prove my comment before wrong. You had the freedom to do different, but chose not to. That's not my problem, don't announce it.

 

[Archelaus]

It’s dominantly not even a looksmaxxing forum. There are tons of users who probably haven’t posted a single post in the looksmaxxing subforum?

i did notice that yeah, mainly new people just flood the ratings section, same 3 people posting stuff that should be in offtopic and ratings in the looksmax section, barely any useful threads, and offtopic same drama

 

[dipenhydramine]

No i'm here to read guides, I'm 15 have a good education, great social and hobbies; kickboxing,dancing, songwriting and singing. None of the lies you wrote up there prove my comment before wrong. You had the freedom to do different, but chose not to. That's not my problem, don't announce it.

you are a salty r****d obsessed with creating some persona that clearly doesnt fit you irl

if you were here to read guides you wouldnt have 3800 posts

you are a larp to compensate for your miserable pathetic irl

you are one of the few users and who should genuinely rope

 

[Mandy?]

No i'm here to read guides, I'm 15 have a good education, great social and hobbies; kickboxing,dancing, songwriting and singing. None of the lies you wrote up there prove my comment before wrong. You had the freedom to do different, but chose not to. That's not my problem, don't announce it.

DNR

 

[tulip]

I never said I was the victim,can’t I fucking ask what I did? You should get a grip because how retarded must you be to go around be like this for no reason

And now i'm retarded. I will cuss out who I want when I want idgaf. I was talking to OP and you decided to but in with nonsense. You dumb cunt. Take a bullet to your fucking brain and then maybe some sense will finally hit you.

 

[long ass username]

temple os

 

[Mandy?]

And now i'm retarded. I will cuss out who I want when I want idgaf. I was talking to OP and you decided to but in with nonsense. You dumb cunt. Take a bullet to your fucking brain and then maybe some sense will finally hit you.

Shut up n****r no one asked you be a disappointment like you are

 

[tulip]

DNR

Right you're weird and dumb, lmao like get sho

you are a salty r****d obsessed with creating some persona that clearly doesnt fit you irl

if you were here to read guides you wouldnt have 3800 posts

you are a larp to compensate for your miserable pathetic irl

you are one of the few users and who should genuinely rope

Had nothing to do with what I said to you. You've gone over 4 different topics in a simple back and forth about you continuing to you read my posts and engage with me after claiming you hate me.



Now i'm a larp, now i should kill myself, now i'm salty and retarded and miserable after telling you calmly about my hobbies and my purpose for being here.


Once again, you said you dislike me, I said nothing is holding you back from putting me on ignore. That hit you hard, now want to dish out insults and argue, whilst im using pure logic. Get a grip.

 

[tulip]

Shut up n****r no one asked you be a disappointment like you are

Oh that was a really good burn!!! No correlation whatsoever to the conversation at hand, but I get that you're just pulling any old insult out of your ass to see if something'll fit.

 

[Mandy?]

Right you're weird and dumb, lmao like get sho

Yeah I’m dumb for wasting a breath on you

 

[dipenhydramine]

Right you're weird and dumb, lmao like get sho

Had nothing to do with what I said to you. You've gone over 4 different topics in a simple back and forth about you continuing to you read my posts and engage with me after claiming you hate me.



Now i'm a larp, now i should kill myself, now i'm salty and retarded and miserable after telling you calmly about my hobbies and my purpose for being here.


Once again, you said you dislike me, I said nothing is holding you back from putting me on ignore. That hit you hard, now want to dish out insults and argue, whilst im using pure logic. Get a grip.

yep you really got me with pure facts and logic

im going to announce how much i hate you as much as i want

you are an attention seeking larp
you are a fucking loser
you should kill yourself
you would not be missed
i dont give a fuck about your hobbies

please slit your neck

 

[tulip]

Yeah I’m dumb for wasting a breath on you

I think an individual like you, breathing at all is dumb. It's never too late, to do the thing.

 

[tulip]

yep you really got me with pure facts and logic

im going to announce how much i hate you as much as i want

you are an attention seeking larp
you are a fucking loser
you should kill yourself
you would not be missed
i dont give a fuck about your hobbies

please slit your neck

View attachment 157052

And once again, dishing out insults brcause i told you to put me on ignore. The mental capacity of some of you is tragic.

You train of thought is:

This person has said something I disagree with, I don't know how to clap back logically..i must insult and have the intention to invoke harm.

It gets old lmao. Hard to believe i'm the "child" here.

 

[Mandy?]

I think an individual like you, breathing at all is dumb. It's never too late, to do the thing.

Haha very funny definitely got me vocal cords vibrating like a bird meanwhile a r****d like you behind a screen deserves the honor far more.

 

[dipenhydramine]

And once again, dishing out insults brcause i told you to put me on ignore. The mental capacity of some of you is tragic.

You train of thought is:

This person has said something I disagree with, I don't know how to clap back logically..i must insult and have the intention to invoke harm.

It gets old lmao. Hard to believe i'm the "child" here.

my train of thought is i dislike you so you should kill your self

 

[tulip]

Haha very funny definitely got me vocal cords vibrating like a bird meanwhile a r****d like you behind a screen deserves the honor far more.

Okay!

 

[tulip]

my train of thought is i dislike you so you should kill your self

Yeah I pointed that out. And to allow a minor on the internet to make you lash out so badly shows how weak your resolve is. Gotta work on that if you wanna make it fsr in life. But given the kind of person you are you might just be better at contributing to this:

 

[dipenhydramine]

Yeah I pointed that out. And to allow a minor on the internet to make you lash out so badly shows how weak your resolve is. Gotta work on that if you wanna make it fsr in life. But given the kind of person you are you might just be better at contributing to this:

View attachment 157060

im a minor too r****d

i can actually hear your fat bloated sausage fingers pressing against the screen go rope

 

[tulip]

im a minor too r****d

i can actually hear your fat bloated sausage fingers pressing against the screen go rope

Just pure projection making shit up as we go. All because I said, to maybe put me on ignore if you disliked me. Once again weak mind weak resolve short attention span. Real boring, NEXT!